Safety, Tolerability, and Pharmacokinetics of Senaparib, a Novel PARP1/2 Inhibitor, in Chinese Patients With Advanced Solid Tumors: A Phase I Trial von Cao, Junning, Guo, Hongqian, Ji, Dongmei, Shen, Weina, Zhang, Shun, Hsieh, Chih-Yi, Xiong Cai, Sui, Edward Tian, Ye, Xu, Cong, Zhang, Pin, Xu, Binghe

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Effects of AgRP inhibition on energy balance and metabolism in rodent models von Dutia, Roxanne, Kim, Andrea J, Modes, Matthew, Rothlein, Robert, Shen, Jane M, Tian, Ye Edward, Ihbais, Jumana, Victory, Sam F, Valcarce, Carmen, Wardlaw, Sharon L

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A phase 1 dose‐escalation study of the poly(ADP‐ribose) polymerase inhibitor senaparib in Australian patients with advanced solid tumors von Gao, Bo, Voskoboynik, Mark, Cooper, Adam, Wilkinson, Kate, Hoon, Siao, Hsieh, Chih‐Yi, Cai, Suixiong, Tian, Ye Edward, Bao, Jun, Ma, Ning, Wang, Chen, Zhang, Ming, Li, Baoyue, Guo, Mingchuan, Zhou, Ruiyu, Wang, Xiaozhu, Xu, Cong, Souza, Paul

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A study of senaparib in combination with temozolomide for the treatment of patients with advanced solid tumors and extensive-stage small cell lung cancer von Gao, Bo, Lin, Chia-Chi, Bai, Li-Yuan, Chung, Wei-Pang, Kao, Wan-Chen, Zielinski, Robert, Shim, Byoung Yong, Hong, Min Hee, Kim, Sang-We, Liu, Chien-Ying, Hsieh, Chih-Yi, Cai, Sui Xiong, Tian, Ye Edward, Liu, Lan, Niu, Tiantian, Halcro, Clare, Li, Baoyue, Ma, Ning, Zhang, Congcong, Chen, Xiangna

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A phase 1 dose-escalation and -expansion study of IMP7068, a WEE1 inhibitor, in patients with advanced solid tumors von Lin, Chia-Chi, Grewal, Jaspreet Singh, Sommerhalder, David, Strauss, James Fredric, Bai, Li-Yuan, Shen, Lin, Yeh, Yu-Min, Hsieh, Chih-Yi, Cai, Sui Xiong, Tian, Ye Edward, Xia, Huan, Zhang, Congcong, Li, Baoyue, Zhang, Ming, Ma, Ning, Zhao, Liping, Ma, Jie, Shi, Huiyan, Yu, Zhixin

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Abstract 3091: Discovery and development of a potent and highly selective WEE1 inhibitor IMP7068 von Cai, Sui Xiong, Ma, Ning, Wang, Xiaozhu, Jiang, Yangzhen, Zhang, Hongxia, Guo, Mingchuan, Zhou, Ruiyu, Tian, Ye Edward

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Abstract 1399: Discovery and development of PARP inhibitor senaparib von Cai, Sui Xiong, Ma, Ning, Wang, Xiaozhu, Jiang, Yangzhen, Guo, Mingchuan, Hsieh, Chih-Yi, Tian, Ye Edward

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Pooled analysis of phase I dose-escalation and dose cohort expansion studies of IMP4297, a novel PARP inhibitor, in Chinese and Australian patients with advanced solid tumors von Cao, Junning, Zhang, Pin, de Souza, Paul L., Gao, Bo, Voskoboynik, Mark, Ji, Dongmei, Shen, Weina, Yang, Sheng, Zhou, Yinglei, Zhang, Rong, Lickliter, Jason D., Hoon, Siao-Nge, Palmieri, David, Cai, Suixiong, Tian, Ye Edward, Ma, Ning, Xu, Cong, Yang, Stone, Zhang, Shuaishuai, Xu, Binghe

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Abstract 1051: Combination of senaparib with temozolomide for the treatment of cancer von Cai, Sui Xiong, Ma, Ning, Wang, Xiaozhu, Ma, Jie, Guo, Mingchuan, Zhou, Ruiyu, Liu, Lan, Hsieh, Chih-Yi, Tian, Ye Edward

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Abstract 1643: Discovery of 1-benzylquinazoline-2,4(1H,3H)-diones as novel and potent PARP inhibitors. SAR of the benzyl group von Cai, Sui Xiong, Xu, Qingbing, Wu, Lizhen, Yin, Feng, Hu, Xiuhua, Wang, Xiaozhu, Jiang, Yangzhen, Bao, Qingli, Wang, Guoxiang, Zhang, Xiuyan, Tian, Ye Edward

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Abstract 4491: Discovery of potent small molecular tubulin inhibitors for the treatment of cancer von Cai, Sui Xiong, Yu, Zenghui, Chen, Lei, Xu, Qingbing, Wu, Lizhen, Liu, Lijun, Yin, Feng, Wang, Guoxiang, Jiang, Yangzhen, Zhang, Xiuyan, Kong, Lingsheng, Bao, Qingli, Tian, Ye Edward

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Abstract 2243A: Discovery of potent hedgehog pathway inhibitors as potential anticancer agents von Cai, Sui Xiong, Xie, Kai, Li, Sicun, Wu, Lizhen, Liu, Lijun, Yin, Feng, Gu, Chengyun, Wang, Xiaozhu, Kang, Sishun, Chen, Shengzhi, Meng, Zheng, Zhang, Yan, Wang, Guoxiang, Fei, Hongqiang, Wang, Dongmei, Tian, Ye Edward

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SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF von TIAN, Ye Edward, CAI, Suixiong

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SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF von TIAN, Ye Edward, CAI, Suixiong

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Abstract C179: Discovery of a series of novel PARP-1 inhibitors with potent in vitro and in vivo activity von Cai, Sui Xiong, Xu, Qingbing, Wu, Lizhen, Liu, Lijun, Jiang, Yangzhen, Bao, Qingli, Wang, Guoxiang, Zhang, Xiuyan, Yin, Feng, Gu, Chengyun, Hu, Xiuhua, Wang, Xiaozhu, Kang, Sishun, Chen, Shengzhi, Tian, Ye Edward

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COMBINATION THERAPY OF PARP INHIBITORS von TIAN, Ye Edward, CAI, Sui Xiong

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Substituted fused heteroaryl compound serving as a kinase inhibitor, and applications thereof von Cai, Suixiong, Tian, Ye Edward

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8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND von TIAN, Ye Edward, CAI, Sui Xiong

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8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND von TIAN, Ye Edward, CAI, Sui Xiong

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SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF von TIAN, Ye Edward, CAI, Suixiong

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