Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease von Kuscu, Cem, Arslan, Sevki, Singh, Ritambhara, Thorpe, Jeremy, Adli, Mazhar

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Reader domain specificity and lysine demethylase-4 family function von Su, Zhangli, Wang, Fengbin, Lee, Jin-Hee, Stephens, Kimberly E., Papazyan, Romeo, Voronina, Ekaterina, Krautkramer, Kimberly A., Raman, Ana, Thorpe, Jeremy J., Boersma, Melissa D., Kuznetsov, Vyacheslav I., Miller, Mitchell D., Taverna, Sean D., Phillips, George N., Denu, John M.

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Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential von Kuntimaddi, Aravinda, Achille, Nicholas J., Thorpe, Jeremy, Lokken, Alyson A., Singh, Ritambhara, Hemenway, Charles S., Adli, Mazhar, Zeleznik-Le, Nancy J., Bushweller, John H.

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The global cost of eliminating avoidable blindness von Armstrong, Kirsten L, Jovic, Martin, Vo-Phuoc, Jennifer L, Thorpe, Jeremy G, Doolan, Brian L

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Mosaicism in Human Health and Disease von Thorpe, Jeremy, Osei-Owusu, Ikeoluwa A, Avigdor, Bracha Erlanger, Tupler, Rossella, Pevsner, Jonathan

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Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels von Huang, Lan, Bichsel, Colette, Norris, Alexis L., Thorpe, Jeremy, Pevsner, Jonathan, Alexandrescu, Sanda, Pinto, Anna, Zurakowski, David, Kleiman, Robin J., Sahin, Mustafa, Greene, Arin K., Bischoff, Joyce

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The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing von Rodin, Rachel E., Dou, Yanmei, Kwon, Minseok, Sherman, Maxwell A., D’Gama, Alissa M., Doan, Ryan N., Rento, Lariza M., Girskis, Kelly M., Bohrson, Craig L., Kim, Sonia N., Nadig, Ajay, Luquette, Lovelace J., Gulhan, Doga C., Park, Peter J., Walsh, Christopher A.

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Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development von Chung, Changuk, Yang, Xiaoxu, Bae, Taejeong, Vong, Keng Ioi, Mittal, Swapnil, Donkels, Catharina, Westley Phillips, H., Li, Zhen, Marsh, Ashley P. L., Breuss, Martin W., Ball, Laurel L., Garcia, Camila Araújo Bernardino, George, Renee D., Gu, Jing, Xu, Mingchu, Barrows, Chelsea, James, Kiely N., Stanley, Valentina, Nidhiry, Anna S., Khoury, Sami, Howe, Gabrielle, Riley, Emily, Xu, Xin, Copeland, Brett, Wang, Yifan, Kim, Se Hoon, Kang, Hoon-Chul, Schulze-Bonhage, Andreas, Haas, Carola A., Urbach, Horst, Prinz, Marco, Limbrick, David D., Gurnett, Christina A., Smyth, Matthew D., Sattar, Shifteh, Nespeca, Mark, Gonda, David D., Imai, Katsumi, Takahashi, Yukitoshi, Chen, Hsin-Hung, Tsai, Jin-Wu, Conti, Valerio, Guerrini, Renzo, Devinsky, Orrin, Silva, Wilson A., Machado, Helio R., Mathern, Gary W., Abyzov, Alexej, Baldassari, Sara, Baulac, Stéphanie, Gleeson, Joseph G.

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Identification of a Mosaic Activating Mutation in GNA11 in Atypical Sturge-Weber Syndrome von Thorpe, Jeremy, Frelin, Laurence P., McCann, Meghan, Pardo, Carlos A., Cohen, Bernard A., Comi, Anne M., Pevsner, Jonathan

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Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels von Huang, Lan, Bichsel, Colette, Norris, Alexis, Thorpe, Jeremy, Pevsner, Jonathan, Alexandrescu, Sanda, Pinto, Anna, Zurakowski, David, Kleiman, Robin J., Sahin, Mustafa, Greene, Arin K., Bischoff, Joyce

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Endothelial GNAQ p.R183Q increases angiopoietin-2 and drives formation of enlarged blood vessels von Huang, Lan, Bichsel, Colette, Norris, Alexis, Thorpe, Jeremy, Pevsner, Jonathan, Alexandrescu, Sanda, Pinto, Anna, Zurakowski, David, Kleiman, Robin J., Sahin, Mustafa, Greene, Arin K., Bischoff, Joyce

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Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability von Bae, Taejeong, Fasching, Liana, Wang, Yifan, Shin, Joo Heon, Suvakov, Milovan, Jang, Yeongjun, Norton, Scott, Dias, Caroline, Mariani, Jessica, Jourdon, Alexandre, Wu, Feinan, Panda, Arijit, Pattni, Reenal, Chahine, Yasmine, Yeh, Rebecca, Roberts, Rosalinda C, Huttner, Anita, Kleinman, Joel E, Hyde, Thomas M, Straub, Richard E, Walsh, Christopher A, Urban, Alexander E, Leckman, James F, Weinberger, Daniel R, Vaccarino, Flora M, Abyzov, Alexej

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Somatic mosaicism reveals clonal distributions of neocortical development von Breuss, Martin W., Yang, Xiaoxu, Schlachetzki, Johannes C. M., Antaki, Danny, Lana, Addison J., Xu, Xin, Chung, Changuk, Chai, Guoliang, Stanley, Valentina, Song, Qiong, Newmeyer, Traci F., Nguyen, An, O’Brien, Sydney, Hoeksema, Marten A., Cao, Beibei, Nott, Alexi, McEvoy-Venneri, Jennifer, Pasillas, Martina P., Barton, Scott T., Copeland, Brett R., Nahas, Shareef, Van Der Kraan, Lucitia, Ding, Yan, Glass, Christopher K., Gleeson, Joseph G.

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Control-independent mosaic single nucleotide variant detection with DeepMosaic von Yang, Xiaoxu, Xu, Xin, Breuss, Martin W., Antaki, Danny, Ball, Laurel L., Chung, Changuk, Shen, Jiawei, Li, Chen, George, Renee D., Wang, Yifan, Bae, Taejeong, Cheng, Yuhe, Abyzov, Alexej, Wei, Liping, Alexandrov, Ludmil B., Sebat, Jonathan L., Gleeson, Joseph G.

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Mapping recurrent mosaic copy number variation in human neurons von Sun, Chen, Kathuria, Kunal, Emery, Sarah B., Kim, ByungJun, Burbulis, Ian E., Shin, Joo Heon, Weinberger, Daniel R., Moran, John V., Kidd, Jeffrey M., Mills, Ryan E., McConnell, Michael J.

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Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia von Zhu, Xiaowei, Zhou, Bo, Pattni, Reenal, Gleason, Kelly, Tan, Chunfeng, Kalinowski, Agnieszka, Sloan, Steven, Fiston-Lavier, Anna-Sophie, Mariani, Jessica, Petrov, Dmitri, Barres, Ben A., Duncan, Laramie, Abyzov, Alexej, Vogel, Hannes, Moran, John V., Vaccarino, Flora M., Tamminga, Carol A., Levinson, Douglas F., Urban, Alexander E.

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Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing von Rodin, Rachel E., Dou, Yanmei, Kwon, Minseok, Sherman, Maxwell A., D’Gama, Alissa M., Doan, Ryan N., Rento, Lariza M., Girskis, Kelly M., Bohrson, Craig L., Kim, Sonia N., Nadig, Ajay, Luquette, Lovelace J., Gulhan, Doga C., Park, Peter J., Walsh, Christopher A.

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Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing von Rodin, Rachel E., Dou, Yanmei, Kwon, Minseok, Sherman, Maxwell A., D’Gama, Alissa M., Doan, Ryan N., Rento, Lariza M., Girskis, Kelly M., Bohrson, Craig L., Kim, Sonia N., Nadig, Ajay, Luquette, Lovelace J., Gulhan, Doga C., Park, Peter J., Walsh, Christopher A.

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Comprehensive identification of somatic nucleotide variants in human brain tissue von Wang, Yifan, Bae, Taejeong, Thorpe, Jeremy, Sherman, Maxwell A, Jones, Attila G, Cho, Sean, Daily, Kenneth, Dou, Yanmei, Ganz, Javier, Galor, Alon, Lobon, Irene, Pattni, Reenal, Rosenbluh, Chaggai, Tomasi, Simone, Tomasini, Livia, Yang, Xiaoxu, Zhou, Bo, Akbarian, Schahram, Ball, Laurel L, Bizzotto, Sara, Emery, Sarah B, Doan, Ryan, Fasching, Liana, Jang, Yeongjun, Juan, David, Lizano, Esther, Luquette, Lovelace J, Moldovan, John B, Narurkar, Rujuta, Oetjens, Matthew T, Rodin, Rachel E, Sekar, Shobana, Shin, Joo Heon, Soriano García, Eduardo, Straub, Richard E, Zhou, Weichen, Chess, Andrew, Gleeson, Joseph G, Marquès i Bonet, Tomàs, 1975, Park, Peter J, Peters, Mette A, Pevsner, Jonathan, Walsh, Christopher A, Weinberger, Daniel R, Brain Somatic Mosaicism Network, Moran, John V, Urban, Alexander E, Kidd, Jeffrey M, Mills, Ryan E, Abyzov, Alexej

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Intrinsic Disorder, Epigenetics, and Leukemia - the MLL-AF9 SAGA von Bushweller, John, Kuntimaddi, Aravinda, Thorpe, Jeremy, Achille, Nicholas, Lokken, Alyson, Singh, Ritambhara, Adli, Mazhar, Zeleznik-Le, Nancy

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