Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases von Nathubhai, Amit, Haikarainen, Teemu, Hayward, Penelope C., Muñoz-Descalzo, Silvia, Thompson, Andrew S., Lloyd, Matthew D., Lehtiö, Lari, Threadgill, Michael D.

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Design and Discovery of 2‑Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases von Nathubhai, Amit, Wood, Pauline J, Lloyd, Matthew D, Thompson, Andrew S, Threadgill, Michael D

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Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis von El-Hamamsy, Mervat H.R.I., Smith, Anthony W., Thompson, Andrew S., Threadgill, Michael D.

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Canada, human rights, and the future of the liberal international order von Thompson, Andrew S.

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Asymmetric synthesis of ENT-03, the predicted mammalian ortholog of the dog fish shark aminosterol trodusquemine (MSI-1436) von Kinney, William A., Phillip Cox, D., Jones, Stephen R., Hessler, Edward J., Karnes, Harold A., Fevig, Thomas L., Hewitt, Bradley D., Sullivan, Ryan, Tseng, Nai-Wen, Pasion, Edward, Beale, Thomas, Rosner, Thorsten, Crouch, Ian T., D’Ambrosio, Stephen, Wade, Peter, Chen, Hui, Gao, Qi, Thompson, Andrew S., Muzzio, Miguel, Barbut, Denise, Zasloff, Michael A.

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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases von Kumpan, Katerina, Nathubhai, Amit, Zhang, Chenlu, Wood, Pauline J., Lloyd, Matthew D., Thompson, Andrew S., Haikarainen, Teemu, Lehtiö, Lari, Threadgill, Michael D.

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Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor von Pierce, Michael E, Parsons, Rodney L, Radesca, Lilian A, Lo, Young S, Silverman, Stuart, Moore, James R, Islam, Qamrul, Choudhury, Anusuya, Fortunak, Joseph M. D, Nguyen, Dieu, Luo, Chi, Morgan, Susan J, Davis, Wayne P, Confalone, Pat N, Chen, Cheng-yi, Tillyer, Richard D, Frey, Lisa, Tan, Lushi, Xu, Feng, Zhao, Dalian, Thompson, Andrew S, Corley, Edward G, Grabowski, Edward J. J, Reamer, Robert, Reider, Paul J

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The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links von Rahman, Khondaker M, Thompson, Andrew S, James, Colin H, Narayanaswamy, Mathangi, Thurston, David E

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Manufacture of the PI3K β‑Sparing Inhibitor Taselisib. Part 1: Early-Stage Development Routes to the Bromobenzoxazepine Core von Remarchuk, Travis, Angelaud, Rémy, Askin, David, Kumar, Archana, Thompson, Andrew S, Cheng, Hua, Reichwein, John F, Chen, Yanping, St-Jean, Frédéric

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Power versus Leadership? von Fitz‐Gerald, Ann, Thompson, Andrew S.

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Tehran 1968 and Reform of the UN Human Rights System von Thompson, Andrew S.

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Effects of 5‐aminoisoquinolinone, a water‐soluble, potent inhibitor of the activity of poly (ADP‐ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock... von McDonald, Michelle C, Mota‐Filipe, Helder, Wright, James A, Abdelrahman, Maha, Threadgill, Michael D, Thompson, Andrew S, Thiemermann, Christoph

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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro von Paine, Helen A., Nathubhai, Amit, Woon, Esther C.Y., Sunderland, Peter T., Wood, Pauline J., Mahon, Mary F., Lloyd, Matthew D., Thompson, Andrew S., Haikarainen, Teemu, Narwal, Mohit, Lehtiö, Lari, Threadgill, Michael D.

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Nuclear Magnetic Resonance Solution Structures of Inter- and Intrastrand Adducts of DNA Cross-Linker SJG-136 von Hopton, Suzanne R, Thompson, Andrew S

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Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions von Thompson, Andrew S, Humphrey, Guy R, DeMarco, Anthony M, Mathre, David J, Grabowski, Edward J. J

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Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)--a potential mechanism for the anti-cancer effects of ibuprofen von Woodman, Timothy J, Wood, Pauline J, Thompson, Andrew S, Hutchings, Thomas J, Steel, Georgina R, Jiao, Ping, Threadgill, Michael D, Lloyd, Matthew D

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5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2) von Sunderland, Peter T, Woon, Esther C. Y, Dhami, Archana, Bergin, Aoife B, Mahon, Mary F, Wood, Pauline J, Jones, Louise A, Tully, Sophie R, Lloyd, Matthew D, Thompson, Andrew S, Javaid, Hashim, Martin, Niall M. B, Threadgill, Michael D

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Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents von Thurston, David E, Bose, D. Subhas, Thompson, Andrew S, Howard, Philip W, Leoni, Alberto, Croker, Stephen J, Jenkins, Terrence C, Neidle, Stephen, Hartley, John A, Hurley, Laurence H

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Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems von Twum, Elvis A., Nathubhai, Amit, Wood, Pauline J., Lloyd, Matthew D., Thompson, Andrew S., Threadgill, Michael D.

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One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs von Woon, Esther C.Y., Sunderland, Peter T., Paine, Helen A., Lloyd, Matthew D., Thompson, Andrew S., Threadgill, Michael D.

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