Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor von Maloney, Patrick R., Khan, Pasha, Hedrick, Michael, Gosalia, Palak, Milewski, Monika, Li, Linda, Roth, Gregory P., Sergienko, Eduard, Suyama, Eigo, Sugarman, Eliot, Nguyen, Kevin, Mehta, Alka, Vasile, Stefan, Su, Ying, Stonich, Derek, Nguyen, Hung, Zeng, Fu-Yue, Novo, Arianna Mangravita, Vicchiarelli, Michael, Diwan, Jena, Chung, Thomas D.Y., Smith, Layton H., Pinkerton, Anthony B.

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Collaborative Pre-competitive Preclinical Drug Discovery with Academics and Pharma/Biotech Partners at Sanford|Burnham: Infrastructure, Capabilities & Operational models von Chung, Thomas D Y

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New p32/gC1qR Ligands for Targeted Tumor Drug Delivery von Paasonen, Lauri, Sharma, Shweta, Braun, Gary B., Kotamraju, Venkata Ramana, Chung, Thomas D. Y., She, Zhi-Gang, Sugahara, Kazuki N., Yliperttula, Marjo, Wu, Bainan, Pellecchia, Maurizio, Ruoslahti, Erkki, Teesalu, Tambet

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Dual-Specificity Phosphatase 3 Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis von Musumeci, Lucia, Kuijpers, Marijke J, Gilio, Karen, Hego, Alexandre, Théâtre, Emilie, Maurissen, Lisbeth, Vandereyken, Maud, Diogo, Catia V, Lecut, Christelle, Guilmain, William, Bobkova, Ekaterina V, Eble, Johannes A, Dahl, Russell, Drion, Pierre, Rascon, Justin, Mostofi, Yalda, Yuan, Hongbin, Sergienko, Eduard, Chung, Thomas D.Y, Thiry, Marc, Senis, Yotis, Moutschen, Michel, Mustelin, Tomas, Lancellotti, Patrizio, Heemskerk, Johan W.M, Tautz, Lutz, Oury, Cécile, Rahmouni, Souad

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Translation to Practice: Accelerating the Cycle of Innovation to Impact von Anderson, Jeff R., Chung, Thomas D.Y., Clark, Leon, Weis, Jennifer A., Danielsen, Andrew J., Khosla, Sundeep, Gores, Gregory J., Badley, Andrew D.

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays von Zhang, Ji-Hu, Chung, Thomas D.Y., Oldenburg, Kevin R.

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Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6‑phosphogluconolactonase Inhibitor (R,Z)‑N‑((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,... von Preuss, Janina, Maloney, Patrick, Peddibhotla, Satyamaheshwar, Hedrick, Michael P, Hershberger, Paul, Gosalia, Palak, Milewski, Monika, Li, Yujie Linda, Sugarman, Eliot, Hood, Becky, Suyama, Eigo, Nguyen, Kevin, Vasile, Stefan, Sergienko, Eduard, Mangravita-Novo, Arianna, Vicchiarelli, Michael, McAnally, Danielle, Smith, Layton H, Roth, Gregory P, Diwan, Jena, Chung, Thomas D.Y, Jortzik, Esther, Rahlfs, Stefan, Becker, Katja, Pinkerton, Anthony B, Bode, Lars

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Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening von Chung, Thomas D Y, Sergienko, Eduard, Millán, José Luis

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ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse von Barak, Larry S, Bai, Yushi, Peterson, Sean, Evron, Tama, Urs, Nikhil M, Peddibhotla, Satyamaheshwar, Hedrick, Michael P, Hershberger, Paul, Maloney, Patrick R, Chung, Thomas D.Y, Rodriguiz, Ramona M, Wetsel, William C, Thomas, James B, Hanson, Glen R, Pinkerton, Anthony B, Caron, Marc G

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Design of High-Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface von Alontaga, Aileen Y, Li, Yifei, Chen, Chih-Hong, Ma, Chen-Ting, Malany, Siobhan, Key, Danielle E, Sergienko, Eduard, Sun, Qing, Whipple, David A, Matharu, Daljit S, Li, Baozong, Vega, Ramir, Li, Yi-Jia, Schoenen, Frank J, Blagg, Brian S. J, Chung, Thomas D.Y, Chen, Yuan

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Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones von Marcinkeviciene, Jovita, Rogers, M.John, Kopcho, Lisa, Jiang, Wenjun, Wang, Kathy, Murphy, Dennis J, Lippy, Jonathan, Link, Steven, Chung, Thomas D.Y, Hobbs, Frank, Haque, Tasir, Trainor, George L, Slee, Andrew, Stern, Andrew M, Copeland, Robert A

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High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1 von Zhai, Dayong, Godoi, Paulo, Sergienko, Eduard, Dahl, Russell, Chan, Xochella, Brown, Brock, Rascon, Justin, Hurder, Andrew, Su, Ying, Chung, Thomas D.Y., Jin, Chaofang, Diaz, Paul, Reed, John C.

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High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects von Rostamighadi, Mojtaba, Kamelshahroudi, Arezou, Mehta, Vaibhav, Zeng, Fu-Yue, Pass, Ian, Chung, Thomas D Y, Salavati, Reza

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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 von Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J

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An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phos... von Berneburg, Isabell, Peddibhotla, Satyamaheshwar, Heimsch, Kim C, Haeussler, Kristina, Maloney, Patrick, Gosalia, Palak, Preuss, Janina, Rahbari, Mahsa, Skorokhod, Oleksii, Valente, Elena, Ulliers, Daniela, Simula, Luigi Felice, Buchholz, Kathrin, Hedrick, Michael P, Hershberger, Paul, Chung, Thomas D Y, Jackson, Michael R, Schwarzer, Evelin, Rahlfs, Stefan, Bode, Lars, Becker, Katja, Pinkerton, Anthony B

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An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Discipl... von de Souza, Andrea, Bittker, Joshua A., Lahr, David L., Brudz, Steve, Chatwin, Simon, Oprea, Tudor I., Waller, Anna, Yang, Jeremy J., Southall, Noel, Guha, Rajarshi, Schürer, Stephan C., Vempati, Uma D., Southern, Mark R., Dawson, Eric S., Clemons, Paul A., Chung, Thomas D.Y.

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes von Schreiber, Stuart L., Kotz, Joanne D., Li, Min, Aubé, Jeffrey, Austin, Christopher P., Reed, John C., Rosen, Hugh, White, E. Lucile, Sklar, Larry A., Lindsley, Craig W., Alexander, Benjamin R., Bittker, Joshua A., Clemons, Paul A., de Souza, Andrea, Foley, Michael A., Palmer, Michelle, Shamji, Alykhan F., Wawer, Mathias J., McManus, Owen, Wu, Meng, Zou, Beiyan, Yu, Haibo, Golden, Jennifer E., Schoenen, Frank J., Simeonov, Anton, Jadhav, Ajit, Jackson, Michael R., Pinkerton, Anthony B., Chung, Thomas D.Y., Griffin, Patrick R., Cravatt, Benjamin F., Hodder, Peter S., Roush, William R., Roberts, Edward, Chung, Dong-Hoon, Jonsson, Colleen B., Noah, James W., Severson, William E., Ananthan, Subramaniam, Edwards, Bruce, Oprea, Tudor I., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Stauffer, Shaun R., Emmitte, Kyle A., Brady, Linda S., Driscoll, Jamie, Li, Ingrid Y., Loomis, Carson R., Margolis, Ronald N., Michelotti, Enrique, Perry, Mary E., Pillai, Ajay, Yao, Yong

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Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme von Li, Yi-Jia, Du, Li, Wang, Jianghai, Vega, Ramir, Lee, Terry D., Miao, Yunan, Aldana-Masangkay, Grace, Samuels, Eric R., Li, Baozong, Ouyang, S. Xiaohu, Colayco, Sharon A., Bobkova, Ekaterina V., Divlianska, Daniela B., Sergienko, Eduard, Chung, Thomas D.Y., Fakih, Marwan, Chen, Yuan

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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase von Stanford, Stephanie M, Diaz, Michael A, Ardecky, Robert J, Zou, Jiwen, Roosild, Tarmo, Holmes, Zachary J, Nguyen, Tiffany P, Hedrick, Michael P, Rodiles, Socorro, Guan, April, Grotegut, Stefan, Santelli, Eugenio, Chung, Thomas D. Y, Jackson, Michael R, Bottini, Nunzio, Pinkerton, Anthony B

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Discovery of β‑Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators von Pinkerton, Anthony B, Peddibhotla, Satyamaheshwar, Yamamoto, Fusayo, Slosky, Lauren M, Bai, Yushi, Maloney, Patrick, Hershberger, Paul, Hedrick, Michael P, Falter, Bekhi, Ardecky, Robert J, Smith, Layton H, Chung, Thomas D. Y, Jackson, Michael R, Caron, Marc G, Barak, Lawrence S

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