Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences von Mendoza, Juan L., Schmidt, André, Li, Qin, Nuvaga, Emmanuel, Barrett, Tyler, Bridges, Robert J., Feranchak, Andrew P., Brautigam, Chad A., Thomas, Philip J.

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Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization von Pinarbasi, Emile S., Cağatay, Tolga, Fung, Ho Yee Joyce, Li, Ying C., Chook, Yuh Min, Thomas, Philip J.

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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene von Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R

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Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells von Valley, Hillary C., Bukis, Katherine M., Bell, Alisa, Cheng, Yi, Wong, Eric, Jordan, Nikole J., Allaire, Normand E., Sivachenko, Andrey, Liang, Feng, Bihler, Hermann, Thomas, Philip J., Mahiou, Jerome, Mense, Martin

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Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface von Hudson, Rhea P., Dawson, Jennifer E., Chong, P. Andrew, Yang, Zhengrong, Millen, Linda, Thomas, Philip J., Brouillette, Christie G., Forman-Kay, Julie D.

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Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions von Bozoky, Zoltan, Krzeminski, Mickael, Muhandiram, Ranjith, Birtley, James R., Al-Zahrani, Ateeq, Thomas, Philip J., Frizzell, Raymond A., Ford, Robert C., Forman-Kay, Julie D.

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The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain von Hoelen, Hanneke, Kleizen, Bertrand, Schmidt, Andre, Richardson, John, Charitou, Paraskevi, Thomas, Philip J, Braakman, Ineke

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Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway von Karamyshev, Andrey L., Patrick, Anna E., Karamysheva, Zemfira N., Griesemer, Dustin S., Hudson, Henry, Tjon-Kon-Sang, Sandra, Nilsson, IngMarie, Otto, Hendrik, Liu, Qinghua, Rospert, Sabine, von Heijne, Gunnar, Johnson, Arthur E., Thomas, Philip J.

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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding von Huerta, Carlos, Jiang, Xin, Trevino, Isaac, Bender, Christopher F., Ferguson, Deborah A., Probst, Brandon, Swinger, Kerren K., Stoll, Vincent S., Thomas, Philip J., Dulubova, Irina, Visnick, Melean, Wigley, W. Christian

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis von Balch, William E, Hutt, Darren M, Herman, David, Rodrigues, Ana P C, Noel, Sabrina, Pilewski, Joseph M, Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W, Schmidt, Andre, Thomas, Philip J, Matsumura, Yoshihiro, Skach, William R, Gentzsch, Martina, Riordan, John R, Sorscher, Eric J, Okiyoneda, Tsukasa, Yates, John R, Lukacs, Gergely L, Frizzell, Raymond A, Manning, Gerard, Gottesfeld, Joel M

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ATP Binding to the Motor Domain from an ABC Transporter Drives Formation of a Nucleotide Sandwich Dimer von Smith, Paul C, Karpowich, Nathan, Millen, Linda, Moody, Jonathan E, Rosen, Jane, Thomas, Philip J, Hunt, John F

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Endoproteolytic Activity of the Proteasome von Liu, Chang-Wei, Corboy, Michael J., DeMartino, George N., Thomas, Philip J.

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IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway von Yang, Dongki, Li, Qin, So, Insuk, Huang, Chou-Long, Ando, Hideaki, Mizutani, Akihiro, Seki, George, Mikoshiba, Katsuhiko, Thomas, Philip J, Muallem, Shmuel

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Gating of CFTR by the STAS domain of SLC26 transporters von Muallem, Shmuel, Ko, Shigeru B.H, Zeng, Weizhong, Dorwart, Michael R, Luo, Xiang, Kim, Kil Hwan, Millen, Linda, Goto, Hidemi, Naruse, Satoru, Soyombo, Abigail, Thomas, Philip J

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Cooperative, ATP-dependent Association of the Nucleotide Binding Cassettes during the Catalytic Cycle of ATP-binding Cassette Transporters von Moody, Jonathan E, Millen, Linda, Binns, Derk, Hunt, John F, Thomas, Philip J

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ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome von Liu, Chang-Wei, Li, Xiaohua, Thompson, David, Wooding, Kerry, Chang, Tsui-ling, Tang, Zhanyun, Yu, Hongtao, Thomas, Philip J., DeMartino, George N.

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Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6 von Shcheynikov, Nikolay, Wang, Youxue, Park, Meeyoung, Ko, Shigeru B H, Dorwart, Michael, Naruse, Satoru, Thomas, Philip J, Muallem, Shmuel

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Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3− secretion: relevance to cystic fibrosis von Wang, Youxue, Soyombo, Abigail A, Shcheynikov, Nikolay, Zeng, Weizhong, Dorwart, Michael, Marino, Christopher R, Thomas, Philip J, Muallem, Shmuel

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N-Alpha-Acetyltransferases and Regulation of CFTR Expression von Vetter, Ali J, Karamyshev, Andrey L, Patrick, Anna E, Hudson, Henry, Thomas, Philip J

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening von Kalid, Ori, Mense, Martin, Fischman, Sharon, Shitrit, Alina, Bihler, Hermann, Ben-Zeev, Efrat, Schutz, Nili, Pedemonte, Nicoletta, Thomas, Philip J., Bridges, Robert J., Wetmore, Diana R., Marantz, Yael, Senderowitz, Hanoch

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