Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma von Jansky, Selina, Sharma, Ashwini Kumar, Körber, Verena, Quintero, Andrés, Toprak, Umut H., Wecht, Elisa M., Gartlgruber, Moritz, Greco, Alessandro, Chomsky, Elad, Grünewald, Thomas G. P., Henrich, Kai-Oliver, Tanay, Amos, Herrmann, Carl, Höfer, Thomas, Westermann, Frank

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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells von Elia, Ilaria, Broekaert, Dorien, Christen, Stefan, Boon, Ruben, Radaelli, Enrico, Orth, Martin F., Verfaillie, Catherine, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota von Akagbosu, Blossom, Tayyebi, Zakieh, Shibu, Gayathri, Paucar Iza, Yoselin A., Deep, Deeksha, Parisotto, Yollanda Franco, Fisher, Logan, Pasolli, H. Amalia, Thevin, Valentin, Elmentaite, Rasa, Knott, Maximilian, Hemmers, Saskia, Jahn, Lorenz, Friedrich, Christin, Verter, Jacob, Wang, Zhong-Min, van den Brink, Marcel, Gasteiger, Georg, Grünewald, Thomas G. P., Marie, Julien C., Leslie, Christina, Rudensky, Alexander Y., Brown, Chrysothemis C.

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Ewing sarcoma von Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Surdez, Didier, Tomazou, Eleni M., de Álava, Enrique, Kovar, Heinrich, Sorensen, Poul H., Delattre, Olivier, Dirksen, Uta

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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours von Jones, David T. W., Banito, Ana, Grünewald, Thomas G. P., Haber, Michelle, Jäger, Natalie, Kool, Marcel, Milde, Till, Molenaar, Jan J., Nabbi, Arash, Pugh, Trevor J., Schleiermacher, Gudrun, Smith, Malcolm A., Westermann, Frank, Pfister, Stefan M.

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Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies von Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity von Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

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Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides von Jin, Darui, Liang, Shangying, Shmatko, Artem, Arnold, Alexander, Horst, David, Grünewald, Thomas G. P., Gerstung, Moritz, Bai, Xiangzhi

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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma von Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

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Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR von Stenger, Dana, Stief, Tanja A., Kaeuferle, Theresa, Willier, Semjon, Rataj, Felicitas, Schober, Kilian, Vick, Binje, Lotfi, Ramin, Wagner, Beate, Grünewald, Thomas G.P., Kobold, Sebastian, Busch, Dirk H., Jeremias, Irmela, Blaeschke, Franziska, Feuchtinger, Tobias

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PHGDH heterogeneity potentiates cancer cell dissemination and metastasis von Rossi, Matteo, Altea-Manzano, Patricia, Demicco, Margherita, Doglioni, Ginevra, Bornes, Laura, Fukano, Marina, Vandekeere, Anke, Cuadros, Alejandro M., Fernández-García, Juan, Riera-Domingo, Carla, Jauset, Cristina, Planque, Mélanie, Alkan, H. Furkan, Nittner, David, Zuo, Dongmei, Broadfield, Lindsay A., Parik, Sweta, Pane, Antonino Alejandro, Rizzollo, Francesca, Rinaldi, Gianmarco, Zhang, Tao, Teoh, Shao Thing, Aurora, Arin B., Karras, Panagiotis, Vermeire, Ines, Broekaert, Dorien, Elsen, Joke Van, Knott, Maximilian M. L., Orth, Martin F., Demeyer, Sofie, Eelen, Guy, Dobrolecki, Lacey E., Bassez, Ayse, Brussel, Thomas Van, Sotlar, Karl, Lewis, Michael T., Bartsch, Harald, Wuhrer, Manfred, Veelen, Peter van, Carmeliet, Peter, Cools, Jan, Morrison, Sean J., Marine, Jean-Christophe, Lambrechts, Diether, Mazzone, Massimiliano, Hannon, Gregory J., Lunt, Sophia Y., Grünewald, Thomas G. P., Park, Morag, Rheenen, Jacco van, Fendt, Sarah-Maria

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Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung von Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

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Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas? von Sannino, Giuseppina, Marchetto, Aruna, Kirchner, Thomas, Grünewald, Thomas G P

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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma von Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F, Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J, Romero-Pérez, Laura, Wehweck, Fabienne S, Musa, Julian, Bestvater, Felix, Knott, Maximilian M L, Hölting, Tilman L B, Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

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A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas von Orth, Martin F., Buecklein, Veit Leonhard, Kampmann, Eric, Subklewe, Marion, Noessner, Elfriede, Cidre-Aranaz, Florencia, Romero-Pérez, Laura, Wehweck, Fabienne Sophie, Lindner, Lars, Issels, Rolf, Kirchner, Thomas, Altendorf-Hofmann, Annelore, Grünewald, Thomas G. P., Knösel, Thomas

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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer von Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries von Boeva, Valentina, Louis-Brennetot, Caroline, Peltier, Agathe, Durand, Simon, Pierre-Eugène, Cécile, Raynal, Virginie, Etchevers, Heather C, Thomas, Sophie, Lermine, Alban, Daudigeos-Dubus, Estelle, Geoerger, Birgit, Orth, Martin F, Grünewald, Thomas G P, Diaz, Elise, Ducos, Bertrand, Surdez, Didier, Carcaboso, Angel M, Medvedeva, Irina, Deller, Thomas, Combaret, Valérie, Lapouble, Eve, Pierron, Gaelle, Grossetête-Lalami, Sandrine, Baulande, Sylvain, Schleiermacher, Gudrun, Barillot, Emmanuel, Rohrer, Hermann, Delattre, Olivier, Janoueix-Lerosey, Isabelle

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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma von Kim, Yong Ryoul, Joo, Jaegeon, Lee, Hee Jung, Kim, Chaelim, Park, Ju-Chan, Yu, Young Suk, Kim, Chang Rok, Lee, Do Hui, Cha, Joowon, Kwon, Hyemin, Hanssen, Kimberley M., Grünewald, Thomas G. P., Choi, Murim, Han, Ilkyu, Bae, Sangsu, Jung, Inkyung, Shin, Yongdae, Baek, Sung Hee

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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes von Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.

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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship von Ceranski, A Katharina, Carreño-Gonzalez, Martha J, Ehlers, Anna C, Colombo, Maria Vittoria, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

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