Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling von Taylor, Samuel J., Dagger, Samantha A., Thien, Christine B.F., Wikstrom, Matthew E., Langdon, Wallace Y.

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Cbl: many adaptations to regulate protein tyrosine kinases von Thien, Christine B. F, Langdon, Wallace Y

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Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells von Gustin, Sonja E, Thien, Christine B. F, Langdon, Wallace Y

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Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action von MOLERO, Juan C, TURNER, Nigel, THIEN, Christine B. F, LANGDON, Wallace Y, JAMES, David E, COONEY, Gregory J

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Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions von Paolino, Magdalena, Thien, Christine B F, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Langdon, Wallace Y, Penninger, Josef M

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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells von Rathinam, Chozhavendan, Thien, Christine B F, Langdon, Wallace Y, Gu, Hua, Flavell, Richard A

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A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis von Kundu, Manikuntala, Pathak, Sushil Kumar, Kumawat, Kuldeep, Basu, Sanchita, Chatterjee, Gargi, Pathak, Shresh, Noguchi, Takuya, Takeda, Kohsuke, Ichijo, Hidenori, Thien, Christine B F, Langdon, Wallace Y, Basu, Joyoti

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Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice von Duyvestyn, Johanna M, Taylor, Samuel J, Dagger, Samantha A, Orandle, Marlene, Morse, 3rd, Herbert C, Thien, Christine B F, Langdon, Wallace Y

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c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses von Thien, Christine B F, Langdon, Wallace Y

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Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling von Rathinam, Chozhavendan, Thien, Christine B.F., Flavell, Richard A., Langdon, Wallace Y.

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Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes von Hoyne, Gerard F, Flening, Eleanor, Yabas, Mehmet, Teh, Charis, Altin, John A, Randall, Katrina, Thien, Christine B F, Langdon, Wallace Y, Goodnow, Christopher C

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c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway von Thien, Christine B.F., Dagger, Samantha A., Steer, James H., Koentgen, Frank, Jansen, Elisa S., Scott, Clare L., Langdon, Wallace Y.

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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion von Thien, Christine BF, Blystad, Frøydis D, Zhan, Yifan, Lew, Andrew M, Voigt, Valentina, Andoniou, Christopher E, Langdon, Wallace Y

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Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor von Oksvold, Morten P, Thien, Christine B F, Widerberg, Jannicke, Chantry, Andrew, Huitfeldt, Henrik S, Langdon, Wallace Y

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The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells von Oksvold, Morten P., Dagger, Samantha A., Thien, Christine B.F., Langdon, Wallace Y.

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Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice von Taylor, Samuel J, Thien, Christine B.F, Dagger, Samantha A, Duyvestyn, Johanna M, Grove, Carolyn S, Lee, Benjamin H, Gilliland, D. Gary, Langdon, Wallace Y

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Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice von Murphy, Maria A., Schnall, Ralf G., Venter, Deon J., Barnett, Louise, Bertoncello, Ivan, Thien, Christine B. F., Langdon, Wallace Y., Bowtell, David D. L.

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UV-Radiation-Induced Internalization of the Epidermal Growth Factor Receptor Requires Distinct Serine and Tyrosine Residues in the Cytoplasmic Carboxy-Terminal Domain von Oksvold, Morten P., Thien, Christine B. F., Widerberg, Jannicke, Chantry, Andrew, Huitfeldt, Henrik S., Langdon, Wallace Y.

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Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice von Mamchak, Alusha A, Thien, Christine B.F, Dagger, Samantha A, Lyandres, Julia, Jiang, Shuwei, Langdon, Wallace Y, DeFranco, Anthony L

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Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl von THIEN, C. B. F, LANGDON, W. Y

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