Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents von TORPHY, T. J

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Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report von Torphy, Theodore J, Allen, Janet, Cantin, André M, Konstan, Michael W, Accurso, Frank J, Joseloff, Elizabeth, Ratjen, Felix A, Chmiel, James F

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Phosphodiesterases: the journey towards therapeutics von Torphy, Theodore J, Page, Clive

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Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B von Manning, Carol D, Burman, Miriam, Christensen, Siegfried B, Cieslinski, Lenora B, Essayan, David M, Grous, Marilyn, Torphy, Theodore J, Barnette, Mary S

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Tumor Necrosis Factor-alpha -Induced Secretion of RANTES and Interleukin-6 from Human Airway Smooth-Muscle Cells . Modulation by Cyclic Adenosine Monophosphate von Ammit, Alaina J, Hoffman, Rebecca K, Amrani, Yassine, Lazaar, Aili L, Hay, Douglas W. P, Torphy, Theodore J, Penn, Raymond B, Panettieri, Reynold A., Jr

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Monoclonal antibodies as a strategy for pulmonary diseases von Torphy, Theodore J, Li, Li, Griswold, Don E

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What's in the Pipeline? Prospects for Monoclonal Antibodies (mAbs) as Therapies for Lung Diseases von Li, Li, Das, Anuk M, Torphy, Theodore J, Griswold, Don E

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Monoclonal antibodies: boundless potential, daunting challenges von Torphy, Theodore J.

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Role of Conserved Histidines in Catalytic Activity and Inhibitor Binding of Human Recombinant Phosphodiesterase 4A von Jacobitz, Susanne, Ryan, M. Dominic, McLaughlin, Megan M., Livi, George P., Dewolf, Walter E., Torphy, Theodore J.

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Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone von Baures, Paul W, Eggleston, Drake S, Erhard, Karl F, Cieslinski, Lenora B, Torphy, Theodore J, Christensen, Siegfried B

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Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils von Chilton, Floyd H, Fonteh, Alfred N, Sung, Chiu-Mei, Hickey, Deirdre M. B, Torphy, Theodore J, Mayer, Ruth J, Marshall, Lisa A, Heravi, Javid D, Winkler, James D

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β-Adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma von Torphy, Theodore J.

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Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response von GRISWOLD, D. E, WEBB, E. F, BRETON, J, WHITE, J. R, MARSHALL, P. J, TORPHY, T. J

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Coming of age: anti-cytokine therapies von Song, Xiao-yu R, Torphy, Theodore J, Griswold, Don E, Shealy, David

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Cysteinyl leukotrienes in asthma: old mediators up to new tricks von Hay, Douglas W.P., Torphy, Theodore J., Undem, Bradley J.

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Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding von Jacobitz, S, McLaughlin, M M, Livi, G P, Burman, M, Torphy, T J

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [ 3H]rolipram binding von Bamette, Mary S., Bartus, Joan O'Leary, Burman, Miriam, Christensen, Siegfried B., Cieslinski, Lenora B., Esser, Klaus M., Prabhakar, Uma S., Rush, Julia A., Torphy, Theodore J.

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A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue dist... von MCLAUGHLIN, M. M, CIESLINSKI, L. B, BURMAN, M, TORPHY, T. J, LIVI, G. P

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Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonis... von Torphy, T J, Zhou, H L, Foley, J J, Sarau, H M, Manning, C D, Barnette, M S

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Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isozymes in canine tracheal smooth muscle von TORPHY, T. J, CIESLINSKI, L. B

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