Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with... von Bjorklund, Chad C., Kang, Jian, Amatangelo, Michael, Polonskaia, Ann, Katz, Mark, Chiu, Hsiling, Couto, Suzana, Wang, Maria, Ren, Yan, Ortiz, Maria, Towfic, Fadi, Flynt, J. Erin, Pierceall, William, Thakurta, Anjan

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Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq von Philpott, Martin, Watson, Jonathan, Thakurta, Anjan, Brown, Tom, Brown, Tom, Oppermann, Udo, Cribbs, Adam P.

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Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response von Amatangelo, Michael D., Quek, Lynn, Shih, Alan, Stein, Eytan M., Roshal, Mikhail, David, Muriel D., Marteyn, Benoit, Farnoud, Noushin Rahnamay, de Botton, Stephane, Bernard, Olivier A., Wu, Bin, Yen, Katharine E., Tallman, Martin S., Papaemmanuil, Elli, Penard-Lacronique, Virginie, Thakurta, Anjan, Vyas, Paresh, Levine, Ross L.

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Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma von Walker, Brian A., Mavrommatis, Konstantinos, Wardell, Christopher P., Ashby, T. Cody, Bauer, Michael, Davies, Faith E., Rosenthal, Adam, Wang, Hongwei, Qu, Pingping, Hoering, Antje, Samur, Mehmet, Towfic, Fadi, Ortiz, Maria, Flynt, Erin, Yu, Zhinuan, Yang, Zhihong, Rozelle, Dan, Obenauer, John, Trotter, Matthew, Auclair, Daniel, Keats, Jonathan, Bolli, Niccolo, Fulciniti, Mariateresa, Szalat, Raphael, Moreau, Philippe, Durie, Brian, Stewart, A. Keith, Goldschmidt, Hartmut, Raab, Marc S., Einsele, Hermann, Sonneveld, Pieter, San Miguel, Jesus, Lonial, Sagar, Jackson, Graham H., Anderson, Kenneth C., Avet-Loiseau, Herve, Munshi, Nikhil, Thakurta, Anjan, Morgan, Gareth J.

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A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis von Walker, Brian A., Mavrommatis, Konstantinos, Wardell, Christopher P., Ashby, T. Cody, Bauer, Michael, Davies, Faith, Rosenthal, Adam, Wang, Hongwei, Qu, Pingping, Hoering, Antje, Samur, Mehmet, Towfic, Fadi, Ortiz, Maria, Flynt, Erin, Yu, Zhinuan, Yang, Zhihong, Rozelle, Dan, Obenauer, John, Trotter, Matthew, Auclair, Daniel, Keats, Jonathan, Bolli, Niccolo, Fulciniti, Mariateresa, Szalat, Raphael, Moreau, Phillipe, Durie, Brian, Stewart, A. Keith, Goldschmidt, Hartmut, Raab, Marc S., Einsele, Hermann, Sonneveld, Pieter, San Miguel, Jesus, Lonial, Sagar, Jackson, Graham H., Anderson, Kenneth C., Avet-Loiseau, Herve, Munshi, Nikhil, Thakurta, Anjan, Morgan, Gareth

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A Phase 2/3 Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Lenalidomide Versus Investigator's Choice in Patients with Relapsed or Refractory Diffus... von Czuczman, Myron S, Trněný, Marek, Davies, Andrew, Rule, Simon, Linton, Kim M, Wagner-Johnston, Nina, Gascoyne, Randy D, Slack, Graham W, Brousset, Pierre, Eberhard, David A, Hernandez-Ilizaliturri, Francisco J, Salles, Gilles, Witzig, Thomas E, Zinzani, Pier Luigi, Wright, George W, Staudt, Louis M, Yang, Yandan, Williams, P Mickey, Lih, Chih-Jian, Russo, Jacqueline, Thakurta, Anjan, Hagner, Patrick, Fustier, Pierre, Song, Dale, Lewis, Ian D

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Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase von Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Subramanyam, Prakash, Anand, Amit, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Hemerich, Daiane, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Ahsan, Aarif, Chiu, Hsiling, Thomas, Geethu, Lind, Evan F, Menezes, Daniel L, Schimmer, Aaron D, Hagner, Patrick R, Gandhi, Anita, Thakurta, Anjan G

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Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group von Samur, Mehmet Kemal, Aktas Samur, Anil, Fulciniti, Mariateresa, Szalat, Raphael, Han, Tessa, Shammas, Masood, Richardson, Paul, Magrangeas, Florence, Minvielle, Stephane, Corre, Jill, Moreau, Philippe, Thakurta, Anjan, Anderson, Kenneth C., Parmigiani, Giovanni, Avet-Loiseau, Herve, Munshi, Nikhil C.

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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL von Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.

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Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma von Flynt, Erin, Bisht, Kamlesh, Sridharan, Vinidhra, Ortiz, Maria, Towfic, Fadi, Thakurta, Anjan

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The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer von Pellegrino, Nicole E, Guven, Arcan, Gray, Kayleigh, Shah, Punit, Kasture, Gargi, Nastke, Maria-Dorothea, Thakurta, Anjan, Gesta, Stephane, Vishnudas, Vivek K, Narain, Niven R, Kiebish, Michael A

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Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets von Sehgal, Kartik, Das, Rituparna, Zhang, Lin, Verma, Rakesh, Deng, Yanhong, Kocoglu, Mehmet, Vasquez, Juan, Koduru, Srinivas, Ren, Yan, Wang, Maria, Couto, Suzana, Breider, Mike, Hansel, Donna, Seropian, Stuart, Cooper, Dennis, Thakurta, Anjan, Yao, Xiaopan, Dhodapkar, Kavita M., Dhodapkar, Madhav V.

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Differential RNA splicing as a potentially important driver mechanism in multiple myeloma von Bauer, Michael A., Ashby, Cody, Wardell, Christopher, Boyle, Eileen M., Ortiz, Maria, Flynt, Erin, Thakurta, Anjan, Morgan, Gareth, Walker, Brian A.

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Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma von Mikulasova, Aneta, Ashby, Cody, Tytarenko, Ruslana G., Qu, Pingping, Rosenthal, Adam, Dent, Judith A., Ryan, Katie R., Bauer, Michael A., Wardell, Christopher P., Hoering, Antje, Mavrommatis, Konstantinos, Trotter, Matthew, Deshpande, Shayu, Yaccoby, Shmuel, Tian, Erming, Keats, Jonathan, Auclair, Daniel, Jackson, Graham H., Davies, Faith E., Thakurta, Anjan, Morgan, Gareth J., Walker, Brian A.

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Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients von Franssen, Laurens E, Nijhof, Inger S, Couto, Suzana, Levin, Mark-David, Bos, Gerard M J, Broijl, Annemiek, Klein, Saskia K, Ren, Yan, Wang, Maria, Koene, Harry R, Bloem, Andries C, Beeker, Aart, Faber, Laura M, van der Spek, Ellen, Raymakers, Reinier, Leguit, Roos J, Sonneveld, Pieter, Zweegman, Sonja, Lokhorst, Henk, Mutis, Tuna, Thakurta, Anjan, Qian, Xiaozhong, van de Donk, Niels W C J

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Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity von Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh

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Multiple myeloma and its treatment contribute to increased platelet reactivity von Mitchell, Joanne L, Khan, Dalia, Rana, Rekha H, Kriek, Neline, Unsworth, Amanda J, Sage, Tanya, Bye, Alexander P, Laffan, Michael, Shapiro, Susan, Thakurta, Anjan, Grech, Henri, Ramasamy, Karthik, Gibbins, Jonathan M

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Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways von Karagoz, Kubra, Stokes, Matthew, Ortiz-Estévez, María, Towfic, Fadi, Flynt, Erin, Gooding, Sarah, Pierceall, William, Thakurta, Anjan

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Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways von Ortiz-Estevez, Maria, Towfic, Fadi, Flynt, Erin, Stong, Nicholas, Jang, In Sock, Wang, Kai, Trotter, Matthew W. B., Thakurta, Anjan

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Immunomodulation of NK, NKT and B/T cell subtypes in relapsed/refractory multiple myeloma patients treated with pomalidomide along with velcade and dexamethasone and its associatio... von Prabhala, Rao, Pierceall, William E, Samur, Mehmet, Potluri, Lakshmi B, Hong, Kevin, Peluso, Teresa, Talluri, Srikanth, Wang, Angela, Katiki, Aishwarya, Vangala, Sahan D, Buonopane, Michael, Bade, Vaishnavi, Seah, Hannah, Krogman, Arthur, Derebail, Sanika, Fulciniti, Mariateresa, Lazo, Suzan B, Richardson, Paul, Anderson, Kenneth, Corre, Jill, Avet-Loiseau, Herve, Thakurta, Anjan, Munshi, Nikhil

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