NAFLD and NASH biomarker qualification in the LITMUS consortium – Lessons learned von Rasmussen, Daniel Guldager Kring, Anstee, Quentin M., Torstenson, Richard, Golding, Bruno, Patterson, Scott D., Brass, Clifford, Thakker, Paresh, Harrison, Stephen, Billin, Andrew N., Schuppan, Detlef, Dufour, Jean-François, Andersson, Anneli, Wigley, Ioan, Shumbayawonda, Elizabeth, Dennis, Andrea, Schoelch, Corinna, Ratziu, Vlad, Yunis, Carla, Bossuyt, Patrick, Karsdal, Morten Asser

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Interleukin 23 Produced by Hepatic Monocyte-Derived Macrophages Is Essential for the Development of Murine Primary Biliary Cholangitis von Reuveni, Debby, Brezis, Miriam R., Brazowski, Eli, Vinestock, Philip, Leung, Patrick S. C., Thakker, Paresh, Gershwin, M. Eric, Zigmond, Ehud

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Therapeutic activity of an interleukin‐4/interleukin‐13 dual antagonist on oxazolone‐induced colitis in mice von Kasaian, Marion T., Page, Karen M., Fish, Susan, Brennan, Agnes, Cook, Timothy A., Moreira, Karen, Zhang, Melvin, Jesson, Michael, Marquette, Kimberly, Agostinelli, Rita, Lee, Julie, Williams, Cara M. M., Tchistiakova, Lioudmila, Thakker, Paresh

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Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality von Marchlik, Erica, Thakker, Paresh, Carlson, Thaddeus, Jiang, Zhaozhao, Ryan, Mark, Marusic, Suzana, Goutagny, Nadege, Kuang, Wen, Askew, G. Roger, Roberts, Victoria, Benoit, Stephen, Zhou, Tianhui, Ling, Vincent, Pfeifer, Richard, Stedman, Nancy, Fitzgerald, Katherine A., Lin, Lih‐Ling, Hall, J. Perry

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Sa1773 MACHINE LEARNING-BASED PRECISION MEDICINE APPROACH IDENTIFIES SPECIFIC RESPONDER SUB-POPULATIONS IN PATIENTS TREATED WITH VEDOLIZUMAB BY DYNAMIC CLUSTERING OF PRO-2 DATA: PO... von Schreiber, Stefan, Ostanin, Dmitry, Cheng, Jie, Agboton, Christian, Yajnik, Vijay, Thakker, Paresh

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1166 WHOLE GENOME SEQUENCING OF CYCLIC VOMITING PATIENTS REVEALS NOVEL RISK LOCI von Downie, Jonathan M., Smith, Erin N., Randunne, Amanda, Arunachalam, Vinayagam, Thakker, Paresh, Kuo, Braden

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TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation von JUNQING CUI, PAZDZIORKO, Stephen, WILLIAMS, Cara M. M, MARUSIC, Suzana, MIYASHIRO, Joy S, THAKKER, Paresh, PELKER, Jeffrey W, DECLERCQ, Charlene, AIPING JIAO, GUNN, Jason, MASON, Lawrence, LEONARD, John P

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Human bronchial epithelial cells express and secrete MMP-12 von Lavigne, Mark C., Thakker, Paresh, Gunn, Jason, Wong, Anthony, Miyashiro, Joy S., Wasserman, Aeona M., Wei, Shui-Qing, Pelker, Jeffrey W., Kobayashi, Michiko, Eppihimer, Michael J.

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50378 Clinical efficacy of TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, is associated with modulation of disease and TYK2 pathway biomarkers in patients wit... von Krueger, James G., Garcet, Sandra, Cheng, Jie, Kumar, Sachin, Blau, Jessamyn, Zhao, Yiwei, Zhang, Wenwen, Arunachalam, Vinayagam, Heap, Graham A., Thakker, Paresh, Choudhury, Amit

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FRI-164 Proteomic analysis identified fazirsiran treatment-responsive protein biomarkers in patients with alpha-1 antitrypsin deficiency-associated liver disease von Chuang, Jen-Chieh, Hou, Ruixue, Hong, Feng, Cheng, Jie, Paraskevopoulou, Maria D., Desai, Nirav K., Thakker, Paresh, Martin, Javier San, Schluep, Thomas, Strnad, Pavel

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FRI-161 Correlation of non-invasive tests with histological features and intrahepatic Z-alpha-1 antitrypsin burden in patients with alpha-1 antitrypsin deficiency-associated liver... von Chuang, Jen-Chieh, Hou, Ruixue, Hong, Feng, Paraskevopoulou, Maria D., Cheng, Jie, Gonzalez, Susana, Desai, Nirav K., Thakker, Paresh, Schluep, Thomas, Martin, Javier San, Loomba, Rohit, Strnad, Pavel

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A randomized phase 2 study of the 5-HT4 receptor agonist felcisetrag for postoperative gastrointestinal dysfunction after bowel surgery von Boeckxstaens, Guy, Ayad, Sabry, Dukes, George, Essandoh, Michael, Gryder, Ryan, Kamble, Pravin, Tackett, Jason, Thakker, Paresh, Williams, James, Zhang, Yanwei, Wade, Paul R.

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A randomized phase 2 study of the 5-HT4 receptor agonist felcisetrag for postoperative gastrointestinal dysfunction after bowel surgery von Boeckxstaens, Guy, Ayad, Sabry, Dukes, George, Essandoh, Michael, Gryder, Ryan, Kamble, Pravin, Tackett, Jason, Thakker, Paresh, Williams, James, Zhang, Yanwei, Wade, Paul R

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A randomized phase 2 study of the 5-HT 4 receptor agonist felcisetrag for postoperative gastrointestinal dysfunction after bowel surgery von Boeckxstaens, Guy, Ayad, Sabry, Dukes, George, Essandoh, Michael, Gryder, Ryan, Kamble, Pravin, Tackett, Jason, Thakker, Paresh, Williams, James, Zhang, Yanwei, Wade, Paul R

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WED-294 The use of the FibroScan-AST score and AST to pre-identify metabolic dysfunction-associated steatohepatitis patients with active fibrogenesis in a Phase 1b open-label clini... von Noureddin, Mazen, Lawitz, Eric, Alkhouri, Naim, Kayali, Zeid, Rudraraju, Madhavi, Mena, Edward, Loomba, Rohit, Hassanein, Tarek, Mantry, Parvez, Siddiqui, Mohammad, Lucas, Kathryn Jean, Reiss, Garry, Aneiros, Oni, Farno, Dawn, Differding, Shawna, Marshall, Debbie, Biracree, Jaime, Devadas, Bruno, Reddy, Praveena, Patel, Chetna, Tsau, Jennifer, Chen, Michael, Mendoza, Michelle, Butler, Scott, Oakley, Holly, Lichtenberger, Wendi, Hambridge, Shannon, Thakker, Paresh, Wennbo, Haakan, Nagy, Peter, Derdak, Zoltan

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Comparison of the Inflammatory Circuits in Psoriasis Vulgaris, Non‒Pustular Palmoplantar Psoriasis, and Palmoplantar Pustular Psoriasis von Wang, Claire Q., Haxhinasto, Sokol, Garcet, Sandra, Kunjravia, Norma, Cueto, Inna, Gonzalez, Juana, Rambhia, Darshna, Harari, Olivier, Sleeman, Matthew A., Hamilton, Jennifer D., Lim, Wei Keat, Freudenberg, Jan, Kalliolias, George D., Thakker, Paresh, Bissonnette, Robert, Krueger, James G.

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Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-anal... von Lee, Jenny A, Alzoubi, Osama, Staufer, Katharina, Holleboom, Adriaan G, de Saint Loup, Marc, Li, Guanlin, Cobbold, Jeremy, Karlas, Thomas, Yoneda, Masato, Hagström, Hannes, Hirooka, Masashi, Rajaram, Ruveena, George, Jacob, Viganò, Mauro, Ridolfo, Sofia, Ekstedt, Mattias, Nasr, Patrik, Fournier-Poizat, Céline, Bossuyt, Patrick M, Pavlides, Michael, Tiniakos, Dina, Burt, Alastair, Oakley, Fiona, Cordell, Heather J, Day, Christopher P, McTeer, Matthew, Bossuyt, Patrick M, Vali, Yasaman, Lee, Jenny, Holleboom, Adriaan G, Verheij, Joanne, Clément, Karine, Paradis, Valerie, Schattenberg, Jörn M, Davies, Susan, McGlinchey, Aiden, Mato, Jose M, Dufour, Jean-François, Masoodi, Mojgan, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Akhtar, Salma, Kelly, Matt, Wigley, Ioan, Romero-Gómez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Rasmussen, Daniel Guldager Kring, Sinisi, Antonia, Sandt, Estelle, Bugianesi, Elisabetta, Armandi, Angelo, Svegliati, Gianluca, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattias, Yki-Järvinen, Hannele, Porthan, Kimmo, Cortez-Pinto, Helena, Rodrigues, Cecilia M P, Valenti, Luca, Pelusi, Serena, Pennisi, Grazia, Miele, Luca, Geier, Andreas, Francis, Susan, Palaniyappan, Naaventhan, Hockings, Paul, Schneider, Moritz, Trylesinski, Aldo, Duffin, Kevin, Perfield, James W, Yunis, Carla, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, McLeod, Euan James, Ross, Trenton, Bernardo, Barbara, Ertle, Judith, Coxson, Harvey, Alexander, Leigh, Kjær, Mette Skalshøi, Davidsen, Peter, Ellegaard, Jens, Balp, Maria-Magdalena, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Douglas, Shankar, Sudha, Fournier-Poizat, Céline, Horan, Gerald, Ho, Gideon, Billin, Andrew, Doward, Lynda, Twiss, James, Gouw, Annette, Hytiroglou, Prodromos

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IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis von Thakker, Paresh, Leach, Michael W, Kuang, Wen, Benoit, Stephen E, Leonard, John P, Marusic, Suzana

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Noninvasive Longitudinal Study of a Magnetic Resonance Imaging Biomarker for the Quantification of Colon Inflammation in a Mouse Model of Colitis von Bianchi, Andrea, Bluhmki, Teresa, Schönberger, Tanja, Kaaru, Eric, Beltzer, Anne, Raymond, Ernest, Wunder, Andreas, Thakker, Paresh, Stierstorfer, Birgit, Stiller, Detlef

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An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD) von Vacca, Michele, Kamzolas, Ioannis, Harder, Lea Mørch, Oakley, Fiona, Trautwein, Christian, Hatting, Maximilian, Ross, Trenton, Bernardo, Barbara, Oldenburger, Anouk, Hjuler, Sara Toftegaard, Ksiazek, Iwona, Lindén, Daniel, Schuppan, Detlef, Rodriguez-Cuenca, Sergio, Tonini, Maria Manuela, Castañeda, Tamara R., Kannt, Aimo, Rodrigues, Cecília M. P., Cockell, Simon, Govaere, Olivier, Daly, Ann K., Allison, Michael, Honnens de Lichtenberg, Kristian, Kim, Yong Ook, Lindblom, Anna, Oldham, Stephanie, Andréasson, Anne-Christine, Schlerman, Franklin, Marioneaux, Jonathon, Sanyal, Arun, Afonso, Marta B., Younes, Ramy, Amano, Yuichiro, Friedman, Scott L., Wang, Shuang, Bhattacharya, Dipankar, Simon, Eric, Paradis, Valérie, Burt, Alastair, Grypari, Ioanna Maria, Davies, Susan, Driessen, Ann, Yashiro, Hiroaki, Pors, Susanne, Worm Andersen, Maja, Feigh, Michael, Yunis, Carla, Bedossa, Pierre, Stewart, Michelle, Cater, Heather L., Wells, Sara, Schattenberg, Jörn M., Anstee, Quentin M., Tiniakos, Dina, Perfield, James W., Petsalaki, Evangelia, Davidsen, Peter, Vidal-Puig, Antonio

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