Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts von Fujimori, Ko, Iguchi, Yusuke, Yamashita, Yukiko, Gohda, Keigo, Teno, Naoki

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FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice von Iguchi, Yusuke, Yamashita, Yukiko, Gohda, Keigo, Oda, Keisuke, Fujimori, Ko, Sera, Yukihiro, Imanaka, Tsuneo, Yamaguchi, Masafumi, Une, Mizuho, Teno, Naoki

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Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure–activity relationship analysis: Ligand-induced H8 helix fluctuation in the... von Gohda, Keigo, Iguchi, Yusuke, Masuda, Arisa, Fujimori, Ko, Yamashita, Yukiko, Teno, Naoki

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Active site-directed plasmin inhibitors: Extension on the P2 residue von Hidaka, Koushi, Gohda, Keigo, Teno, Naoki, Wanaka, Keiko, Tsuda, Yuko

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Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activit... von Teno, Naoki, Yamashita, Yukiko, Masuda, Arisa, Iguchi, Yusuke, Oda, Keisuke, Fujimori, Ko, Hiramoto, Takie, Nishimaki-Mogami, Tomoko, Une, Mizuho, Gohda, Keigo

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Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists von Teno, Naoki, Iguchi, Yusuke, Yamashita, Yukiko, Mori, Nobuhiro, Une, Mizuho, Nishimaki-Mogami, Tomoko, Gohda, Keigo

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Nonacidic Chemotype Possessing N‑Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists von Teno, Naoki, Yamashita, Yukiko, Iguchi, Yusuke, Fujimori, Ko, Une, Mizuho, Nishimaki-Mogami, Tomoko, Hiramoto, Takie, Gohda, Keigo

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Identification of novel plasmin inhibitors possessing nitrile moiety as warhead von Teno, Naoki, Gohda, Keigo, Wanaka, Keiko, Sueda, Takuya, Tsuda, Yuko

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Synthetic Substrates Specific to Activated Plasmin Can Monitor the Enzymatic Functional Status in Situ in Breast Cancer Cells von Gohda, Keigo, Fujimori, Ko, Teno, Naoki, Wanaka, Keiko, Tsuda, Yuko

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Effect of Cathepsin K Inhibitors on Bone Resorption von Teno, Naoki, Masuya, Keiichi, Ehara, Takeru, Kosaka, Takatoshi, Miyake, Takahiro, Irie, Osamu, Hitomi, Yuko, Matsuura, Naoko, Umemura, Ichiro, Iwasaki, Genji, Fukaya, Hiroaki, Toriyama, Kazuhiro, Uchiyama, Noriko, Nonomura, Kazuhiko, Sugiyama, Ikuo, Kometani, Motohiko

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Discovery of FXR/PPARγ dual partial agonist von Yamashita, Yukiko, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Oda, Keisuke, Masuda, Arisa, Une, Mizuho, Teno, Naoki

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N 1 -Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR) von Masuda, Arisa, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Yamashita, Yukiko, Oda, Keisuke, Une, Mizuho, Teno, Naoki

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Species Differences Between Human and Rat in the Substrate Specificity of Cathepsin K von Tada, Sachiyo, Tsutsumi, Kae, Ishihara, Hideki, Suzuki, Kenji, Gohda, Keigo, Teno, Naoki

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N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR) von Masuda, Arisa, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Yamashita, Yukiko, Oda, Keisuke, Une, Mizuho, Teno, Naoki

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Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum von Teno, Naoki, Iguchi, Yusuke, Oda, Keisuke, Yamashita, Yukiko, Masuda, Arisa, Fujimori, Ko, Une, Mizuho, Gohda, Keigo

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Ag- and Au-Catalyzed Addition of Alcohols to Ynimides: β‑Regioselective Carbonylation and Production of Oxazoles von Sueda, Takuya, Kawada, Arisa, Urashi, Yumi, Teno, Naoki

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N-Alkynyl Imides (Ynimides): Synthesis and Use as a Variant of Highly Labile Ethynamine von Sueda, Takuya, Oshima, Ayumi, Teno, Naoki

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Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity von Teno, Naoki, Gohda, Keigo, Yamashita, Yukiko, Otsubo, Tadamune, Yamaguchi, Masafumi, Wanaka, Keiko, Tsuda, Yuko

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Novel type of plasmin inhibitors: Providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine von Teno, Naoki, Gohda, Keigo, Wanaka, Keiko, Tsuda, Yuko, Akagawa, Maiko, Akiduki, Eriko, Araki, Mitsuhito, Masuda, Arisa, Otsubo, Tadamune, Yamashita, Yukiko

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Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin von Teno, Naoki, Gohda, Keigo, Wanaka, Keiko, Tsuda, Yuko, Sueda, Takuya, Yamashita, Yukiko, Otsubo, Tadamune

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