Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a... von Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R

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The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2 von Winters, Michael P., Teleha, Christopher A., Kang, Fu-An, McComsey, David, O’Neill, John C., Hou, Cuifen, Kirchner, Thomas, Wang, Ping, Johnson, Dana, Sui, Zhihua

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Practical Synthesis of Ethyl 3‑Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus von René, Adeline, Quilan, Maxime, Deng, Yicheng, Cheng, Yang, Teleha, Christopher A, Raboisson, Pierre, Bonfanti, Jean-François, Fortin, Jérôme, Charette, André. B, Pannecoucke, Xavier, Poisson, Thomas, Jubault, Philippe

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6‑Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity von Zhang, Yue-Mei, Greco, Michael N, Macielag, Mark J, Teleha, Christopher A, DesJarlais, Renee L, Tang, Yuting, Ho, George, Hou, Cuifen, Chen, Cailin, Zhao, Shuyuan, Kauffman, Jack, Camacho, Raul, Qi, Jenson, Murray, William, Demarest, Keith, Leonard, James

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Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition von Winters, Michael P., Teleha, Christopher A., Sui, Zhihua

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Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole von Sun, Jung-Hui, Teleha, Christopher A, Yan, Jia-Sheng, Rodgers, James D, Nugiel, David A

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Lab-Scale Preparation of a Novel Cyclopenta[b]furan Chemokine Receptor Antagonist von Teleha, Christopher A, Branum, Shawn, Zhang, Yongzheng, Reuman, Michael E, Van Der Steen, Luc, Verbeek, Marc, Fawzy, Nagy, Leo, Gregory C, Winters, Michael P, Kang, Fu-An, Kolpak, Michael, Beauchamp, Derek A, Lanter, James C, Russell, Ronald K, Sui, Zhihua, Vanbaelen, Hilde

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Lab-Scale Preparation of a Novel Carbocyclic Chemokine Receptor Antagonist von Teleha, Christopher A, Branum, Shawn, Zhang, Yongzheng, Reuman, Michael E, Van Der Steen, Luc, Verbeek, Marc, Fawzy, Nagy, Leo, Gregory C, Kang, Fu-An, Cai, Chaozhong, Kolpak, Michael, Beauchamp, Derek A, Wall, Mark J, Russell, Ronald K, Sui, Zhihua, Vanbaelen, Hilde

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Synthesis of Mavatrep: A Potent Antagonist of Transient Receptor Potential Vanilloid‑1 von Wells, Kenneth M, Mehrman, Steven J, Abdel-Magid, Ahmed F, Ferraro, Caterina, Scott, Lorraine, Zhong, Hua Marlon, Teleha, Christopher A, Ballentine, Scott, Li, Xun, Russell, Ronald K, Spink, Jan M, Diamond, Craig, Youells, Scott, Zhang, Yongzheng, Tsay, Fuh-Rong, Cesco-Cancia, Sergio, Manzo, Stephen M, Beauchamp, Derek A

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Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro von BARBOSA, Maria D. F. S, SIQI LIN, KURILLA, Michael G, POMPLIANO, David L, MARKWALDER, Jay A, MILLS, Jonathan A, DEVITO, Joseph A, TELEHA, Christopher A, GARLAPATI, Vasudha, LIU, Charles, THOMPSON, Andy, TRAINOR, George L

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants von Lam, Patrick Y. S, Clark, Charles G, Li, Renhua, Pinto, Donald J. P, Orwat, Michael J, Galemmo, Robert A, Fevig, John M, Teleha, Christopher A, Alexander, Richard S, Smallwood, Angela M, Rossi, Karen A, Wright, Matthew R, Bai, Stephen A, He, Kan, Luettgen, Joseph M, Wong, Pancras C, Knabb, Robert M, Wexler, Ruth R

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Suzuki−Miyaura Approach to JNJ-26076713, an Orally Active Tetrahydroquinoline-Containing αVβ3/αVβ5 Integrin Antagonist. Enantioselective Synthesis and Stereochemical Studies von Kinney, William A, Teleha, Christopher A, Thompson, Andrew S, Newport, Maria, Hansen, Ryan, Ballentine, Scott, Ghosh, Shyamali, Mahan, Andrew, Grasa, Gabriela, Zanotti-Gerosa, Antonio, Dingenen, Jules, Schubert, Carsten, Zhou, Yong, Leo, Gregory C, McComsey, David F, Santulli, Rosemary J, Maryanoff, Bruce E

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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo von Xue, Chu-Biao, Voss, Matthew E, Nelson, David J, Duan, James J.-W, Cherney, Robert J, Jacobson, Irina C, He, Xiaohua, Roderick, John, Chen, Lihua, Corbett, Ronald L, Wang, Li, Meyer, Dayton T, Kennedy, Kenneth, DeGrado, William F, Hardman, Karl D, Teleha, Christopher A, Jaffee, Bruce D, Liu, Rui-Qin, Copeland, Robert A, Covington, Maryanne B, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P

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Isolation and synthesis of 2-chloro-10-α-hydroxynaltrexone, a new naltrexone degradant von Meredith, Walter, Nemeth, Gregory A, Boucher, Robert, Carney, Robert, Haas, Michael, Sigvardson, Ken, Teleha, Christopher A

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2-Fluoro-4-pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release-Enhancing Agents with Good Efficacy and Duration of Action von Earl, Richard A, Zaczek, Robert, Teleha, Christopher A, Fisher, Barbara N, Maciag, Carla M, Marynowski, Maria E, Logue, Andrew R, Tam, S. William, Tinker, William J, Huang, Shiew-Mei, Chorvat, Robert J

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Imidazo[4,5- b]pyridines as corticotropin releasing factor receptor ligands von Arvanitis, Argyrios G., Rescinito, Joseph T., Arnold, Charles R., Wilde, Richard G., Cain, Gary A., Sun, Jung Hui, Yan, Jia-Sheng, Teleha, Christopher A., Fitzgerald, Lawrence W., McElroy, John, Zaczek, Robert, Hartig, Paul R., Grossman, Scott, Arneric, Stephen P., Gilligan, Paul J., Olson, Richard E., Robertson, David W.

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Boat/chair topographic stereoselection during anionic oxy-Cope rearrangement of 1-alkenyl-2-cyclopentenyl-endo-norbornan-2-ols von Paquette, Leo A, Teleha, Christopher A, Taylor, Richard T, Maynard, George D, Rogers, Robin D, Gallucci, Judith C, Springer, James P

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Chiral aminocyclopentene-based cycloaddition strategies to bicyclic [3.3.0] rings von Cai, Chaozhong, Kang, Fu-An, Beauchamp, Derek A., Sui, Zhihua, Russell, Ronald K., Teleha, Christopher A.

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ChemInform Abstract: Synthesis of Substituted 2,4,5,6-Tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles by Intramolecular Nitrilimine Cycloaddition von Winters, Michael P., Teleha, Christopher A., Sui, Zhihua

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Application of Modified Flavone Closure for the Preparation of Racemic L86-8275 von Tabaka, A. Christine, Murthi, Krishna K, Pal, Kollol, Teleha, Christopher A

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