The Target of Rapamycin and Mechanisms of Cell Growth von Tee, Andrew R

Volltext

Leucine and mTORC1: a complex relationship von Dodd, Kayleigh M, Tee, Andrew R

Volltext

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E von Fingar, Diane C., Richardson, Celeste J., Tee, Andrew R., Cheatham, Lynn, Tsou, Christina, Blenis, John

Volltext

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb von Tee, Andrew R, Manning, Brendan D, Roux, Philippe P, Cantley, Lewis C, Blenis, John

Volltext

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation von Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine A, Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J, Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S, Davies, David Mark, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A M, Jones, Russell, Tee, Andrew R, Pause, Arnim

Volltext

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling von Fonseca, Bruno D., Diering, Graham H., Bidinosti, Michael A., Dalal, Kush, Alain, Tommy, Balgi, Aruna D., Forestieri, Roberto, Nodwell, Matt, Rajadurai, Charles V., Gunaratnam, Cynthia, Tee, Andrew R., Duong, Franck, Andersen, Raymond J., Orlowski, John, Numata, Masayuki, Sonenberg, Nahum, Roberge, Michel

Volltext

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway von Manning, Brendan D, Tee, Andrew R, Logsdon, M.Nicole, Blenis, John, Cantley, Lewis C

Volltext

The zinc finger/RING domain protein Unkempt regulates cognitive flexibility von Vinsland, Elin, Baskaran, Pranetha, Mihaylov, Simeon R., Hobbs, Carl, Wood, Hannah, Bouybayoune, Ihssane, Shah, Kriti, Houart, Corinne, Tee, Andrew R., Murn, Jernej, Fernandes, Cathy, Bateman, Joseph M.

Volltext

The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses von Smith, Ewan M., Finn, Stephen G., Tee, Andrew R., Browne, Gareth J., Proud, Christopher G.

Volltext

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning von Cai, Sheng-Li, Tee, Andrew R, Short, John D, Bergeron, Judith M, Kim, Jinhee, Shen, Jianjun, Guo, Ruifeng, Johnson, Charles L, Kiguchi, Kaoru, Walker, Cheryl Lyn

Volltext

Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin von Tee, Andrew R., Anjum, Rana, Blenis, John

Volltext

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity von Xie, Jianling, Ponuwei, Godwin A., Moore, Claire E., Willars, Gary B., Tee, Andrew R., Herbert, Terence P.

Volltext

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions for substrate r... von Dunlop, Elaine A., Dodd, Kayleigh M., Seymour, Lyndsey A., Tee, Andrew R.

Volltext

Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif von Land, Stephen C., Tee, Andrew R.

Volltext

Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers von Bhaoighill, Muireann Ní, Falcón‐Pérez, Juan M., Royo, Félix, Tee, Andrew R., Webber, Jason P., Dunlop, Elaine A.

Volltext

Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif von Tee, Andrew R., Proud, Christopher G.

Volltext

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS von Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew R., Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa, Walker, Cheryl Lyn

Volltext

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis von Baskaran, Pranetha, Mihaylov, Simeon R., Vinsland, Elin, Shah, Kriti, Granat, Lucy, Ultanir, Sila K., Tee, Andrew R., Murn, Jernej, Bateman, Joseph M.

Volltext

Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation von Schalm, Stefanie S., Tee, Andrew R., Blenis, John

Volltext

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis von Xie, Jianling, Shen, Kaikai, Jones, Ashley T., Yang, Jian, Tee, Andrew R., Shen, Ming Hong, Yu, Mengyuan, Irani, Swati, Wong, Derick, Merrett, James E., Lenchine, Roman V., De Poi, Stuart, Jensen, Kirk B., Trim, Paul J., Snel, Marten F., Kamei, Makoto, Martin, Sally Kim, Fitter, Stephen, Tian, Shuye, Wang, Xuemin, Butler, Lisa M., Zannettino, Andrew C. W., Proud, Christopher G.

Volltext