Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches von Bass, Phillip D, Gubler, Daniel A, Judd, Ted C, Williams, Robert M

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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) von Cheng, Yuan, Judd, Ted C, Bartberger, Michael D, Brown, James, Chen, Kui, Fremeau, Robert T, Hickman, Dean, Hitchcock, Stephen A, Jordan, Brad, Li, Vivian, Lopez, Patricia, Louie, Steven W, Luo, Yi, Michelsen, Klaus, Nixey, Thomas, Powers, Timothy S, Rattan, Claire, Sickmier, E. Allen, St. Jean, David J, Wahl, Robert C, Wen, Paul H, Wood, Stephen

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STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells von BABIJ, Carol, YIHONG ZHANG, FAJARDO, Flordeliza, JACKSON, Angela, ZONDLO, James, YU SUN, ELLISON, Aaron R, PLEWA, Cherylene A, SAN MIGUEL, Tisha, ROBINSON, John, MCCARTER, John, SCHWANDNER, Ralf, KURZEJA, Robert J, JUDD, Ted, CARNAHAN, Josette, DUSSAULT, Isabelle, MUNZLI, Anke, SHEHABELDIN, Amro, FERNANDO, Manory, QUON, Kim, KASSNER, Paul D, RUEFLI-BRASSE, Astrid A, WATSON, Vivienne J

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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease von Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.

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Concise Enantioselective Synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-Mediated Construction of the Hydroxylamine Hemiketal von Judd, Ted C., Williams, Robert M.

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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities von Cheng, Yuan, Brown, James, Judd, Ted C, Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S, Chen, Jian Jeffrey, Bartberger, Michael D, Chen, Kui, Dunn, Robert T, Epstein, Oleg, Fremeau, Robert T, Harried, Scott, Hickman, Dean, Hitchcock, Stephen A, Luo, Yi, Minatti, Ana Elena, Patel, Vinod F, Vargas, Hugo M, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, White, Ryan D, Whittington, Douglas A, Zheng, Xiao Mei, Wood, Stephen

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Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine von Judd, Ted C., Brown, Derek B.

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Structure Determination of Mycolactone C via Total Synthesis von Judd, Ted C, Bischoff, Alexander, Kishi, Yoshito, Adusumilli, Sarojini, Small, Pamela L. C

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A Concise Total Synthesis of (+)-FR900482 and (+)-FR66979 von Judd, Ted C, Williams, Robert M

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Synthesis and DNA Cross-Linking of a Phototriggered FR900482 Mitosene Progenitor von Judd, Ted C, Williams, Robert M

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Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase von Jordan, John B, Whittington, Douglas A, Bartberger, Michael D, Sickmier, E Allen, Chen, Kui, Cheng, Yuan, Judd, Ted

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Synthesis of the First Photo-Triggered Pro-mitosene Based on FR-900482 von Williams, Robert M, Rollins, Samuel B, Judd, Ted C

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Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase von Jordan, John B., Whittington, Douglas A., Bartberger, Michael D., Sickmier, E. Allen, Chen, Kui, Cheng, Yuan, Judd, Ted

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Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase von Jordan, John B., Whittington, Douglas A., Bartberger, Michael D., Sickmier, E. Allen, Chen, Kui, Cheng, Yuan, Judd, Ted

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Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase von Jordan, John B, Whittington, Douglas A, Bartberger, Michael D, Sickmier, E. Allen, Chen, Kui, White, Ryan D, Cheng, Yuan, Judd, Ted

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Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase von Jordan, John B, Whittington, Douglas A, Bartberger, Michael D, Sickmier, E Allen, Chen, Kui, White, Ryan D, Cheng, Yuan, Judd, Ted

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid von Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors von Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS von Zhang, Yihong, Kurzeja, Robert, Munzli, Anke, Zondlo, James, Miguel, Tisha San, Robinson, John, McCarter, John, Schwandner, Ralf, Judd, Ted, Fernando, Manory, Babij, Carol, Carnahan, Josette, Dussault, Isabelle

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase von Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen

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