DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution von Rosenthal, Rachel, McGranahan, Nicholas, Herrero, Javier, Taylor, Barry S, Swanton, Charles

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Translational Landscape of the Mammalian Cell Cycle von Stumpf, Craig R, Moreno, Melissa V, Olshen, Adam B, Taylor, Barry S, Ruggero, Davide

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Automated network analysis identifies core pathways in glioblastoma von Cerami, Ethan, Demir, Emek, Schultz, Nikolaus, Taylor, Barry S, Sander, Chris

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Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers von Landa, Iñigo, Ibrahimpasic, Tihana, Boucai, Laura, Sinha, Rileen, Knauf, Jeffrey A, Shah, Ronak H, Dogan, Snjezana, Ricarte-Filho, Julio C, Krishnamoorthy, Gnana P, Xu, Bin, Schultz, Nikolaus, Berger, Michael F, Sander, Chris, Taylor, Barry S, Ghossein, Ronald, Ganly, Ian, Fagin, James A

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Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer von Lee, Suk Hyung, Hu, Wenhuo, Matulay, Justin T., Silva, Mark V., Owczarek, Tomasz B., Kim, Kwanghee, Chua, Chee Wai, Barlow, LaMont J., Kandoth, Cyriac, Williams, Alanna B., Bergren, Sarah K., Pietzak, Eugene J., Anderson, Christopher B., Benson, Mitchell C., Coleman, Jonathan A., Taylor, Barry S., Abate-Shen, Cory, McKiernan, James M., Al-Ahmadie, Hikmat, Solit, David B., Shen, Michael M.

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Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity von Chang, Matthew T, Asthana, Saurabh, Gao, Sizhi Paul, Lee, Byron H, Chapman, Jocelyn S, Kandoth, Cyriac, Gao, JianJiong, Socci, Nicholas D, Solit, David B, Olshen, Adam B, Schultz, Nikolaus, Taylor, Barry S

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Homing in on genomic instability as a therapeutic target in cancer von Bielski, Craig M., Taylor, Barry S.

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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer von Yaeger, Rona, Chatila, Walid K., Lipsyc, Marla D., Hechtman, Jaclyn F., Cercek, Andrea, Sanchez-Vega, Francisco, Jayakumaran, Gowtham, Middha, Sumit, Zehir, Ahmet, Donoghue, Mark T.A., You, Daoqi, Viale, Agnes, Kemeny, Nancy, Segal, Neil H., Stadler, Zsofia K., Varghese, Anna M., Kundra, Ritika, Gao, Jianjiong, Syed, Aijazuddin, Hyman, David M., Vakiani, Efsevia, Rosen, Neal, Taylor, Barry S., Ladanyi, Marc, Berger, Michael F., Solit, David B., Shia, Jinru, Saltz, Leonard, Schultz, Nikolaus

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First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial von Janjigian, Yelena Y, Maron, Steven B, Chatila, Walid K, Millang, Brittanie, Chavan, Shweta S, Alterman, Carly, Chou, Joanne F, Segal, Michal F, Simmons, Marc Z, Momtaz, Parisa, Shcherba, Marina, Ku, Geoffrey Y, Zervoudakis, Alice, Won, Elizabeth S, Kelsen, David P, Ilson, David H, Nagy, Rebecca J, Lanman, Richard B, Ptashkin, Ryan N, Donoghue, Mark T A, Capanu, Marinela, Taylor, Barry S, Solit, David B, Schultz, Nikolaus, Hechtman, Jaclyn F

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Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma von Moore, Amanda R, Ceraudo, Emilie, Sher, Jessica J, Guan, Youxin, Shoushtari, Alexander N, Chang, Matthew T, Zhang, Jenny Q, Walczak, Edward G, Kazmi, Manija A, Taylor, Barry S, Huber, Thomas, Chi, Ping, Sakmar, Thomas P, Chen, Yu

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Copy number alteration burden predicts prostate cancer relapse von Hieronymus, Haley, Schultz, Nikolaus, Gopalan, Anuradha, Carver, Brett S., Chang, Matthew T., Xiao, Yonghong, Heguy, Adriana, Huberman, Kety, Bernstein, Melanie, Assel, Melissa, Murali, Rajmohan, Vickers, Andrew, Scardino, Peter T., Sander, Chris, Reuter, Victor, Taylor, Barry S., Sawyers, Charles L.

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Marked Response of a Hypermutated ACTH-Secreting Pituitary Carcinoma to Ipilimumab and Nivolumab von Lin, Andrew L, Jonsson, Philip, Tabar, Viviane, Yang, T Jonathan, Cuaron, John, Beal, Katherine, Cohen, Marc, Postow, Michael, Rosenblum, Marc, Shia, Jinru, DeAngelis, Lisa M, Taylor, Barry S, Young, Robert J, Geer, Eliza B

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Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma von Audenet, François, Isharwal, Sumit, Cha, Eugene K, Donoghue, Mark T A, Drill, Esther N, Ostrovnaya, Irina, Pietzak, Eugene J, Sfakianos, John P, Bagrodia, Aditya, Murugan, Paari, Dalbagni, Guido, Donahue, Timothy F, Rosenberg, Jonathan E, Bajorin, Dean F, Arcila, Maria E, Hechtman, Jaclyn F, Berger, Michael F, Taylor, Barry S, Al-Ahmadie, Hikmat, Iyer, Gopa, Bochner, Bernard H, Coleman, Jonathan A, Solit, David B

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Integrative Genomic Profiling of Human Prostate Cancer von Taylor, Barry S., Schultz, Nikolaus, Hieronymus, Haley, Gopalan, Anuradha, Xiao, Yonghong, Carver, Brett S., Arora, Vivek K., Kaushik, Poorvi, Cerami, Ethan, Reva, Boris, Antipin, Yevgeniy, Mitsiades, Nicholas, Landers, Thomas, Dolgalev, Igor, Major, John E., Wilson, Manda, Socci, Nicholas D., Lash, Alex E., Heguy, Adriana, Eastham, James A., Scher, Howard I., Reuter, Victor E., Scardino, Peter T., Sander, Chris, Sawyers, Charles L., Gerald, William L.

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The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma von Ladanyi, Marc, Bott, Matthew, Brevet, Marie, Taylor, Barry S, Shimizu, Shigeki, Ito, Tatsuo, Wang, Lu, Creaney, Jenette, Lake, Richard A, Zakowski, Maureen F, Reva, Boris, Sander, Chris, Delsite, Robert, Powell, Simon, Zhou, Qin, Shen, Ronglai, Olshen, Adam, Rusch, Valerie

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Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing von Hensley, Martee L., Chavan, Shweta S., Solit, David B., Murali, Rajmohan, Soslow, Robert, Chiang, Sarah, Jungbluth, Achim A., Bandlamudi, Chaitanya, Srinivasan, Preethi, Tap, William D., Rosenbaum, Evan, Taylor, Barry S., Donoghue, Mark T. A., Hyman, David M.

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V⁶⁰⁰EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway von Pratilas, Christine A, Taylor, Barry S, Ye, Qing, Viale, Agnes, Sander, Chris, Solit, David B, Rosen, Neal

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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets von Gao, Jianjiong, Chang, Matthew T, Johnsen, Hannah C, Gao, Sizhi Paul, Sylvester, Brooke E, Sumer, Selcuk Onur, Zhang, Hongxin, Solit, David B, Taylor, Barry S, Schultz, Nikolaus, Sander, Chris

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Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer von IYER, Gopa, AL-AHMADIE, Hikmat, ZABOR, Emily C, JANAKIRAMAN, Manickam, GARCIA-GROSSMAN, Ilana R, HEGUY, Adriana, VIALE, Agnes, BOCHNER, Bernard H, REUTER, Victor E, BAJORIN, Dean F, MILOWSKY, Matthew I, TAYLOR, Barry S, SCHULTZ, Nikolaus, SOLIT, David B, HANRAHAN, Aphrothiti J, OSTROVNAYA, Irina, BALAR, Arjun V, KIM, Philip H, LIN, Oscar, WEINHOLD, Nils, SANDER, Chris

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DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors von Mazor, Tali, Pankov, Aleksandr, Johnson, Brett E., Hong, Chibo, Hamilton, Emily G., Bell, Robert J.A., Smirnov, Ivan V., Reis, Gerald F., Phillips, Joanna J., Barnes, Michael J., Idbaih, Ahmed, Alentorn, Agusti, Kloezeman, Jenneke J., Lamfers, Martine L.M., Bollen, Andrew W., Taylor, Barry S., Molinaro, Annette M., Olshen, Adam B., Chang, Susan M., Song, Jun S., Costello, Joseph F.

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