Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors von Green, Jeremy, Cao, Jingrong, Bandarage, Upul K, Gao, Huai, Court, John, Marhefka, Craig, Jacobs, Marc, Taslimi, Paul, Newsome, David, Nakayama, Tomoko, Shah, Sundeep, Rodems, Steve

Volltext

The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity von Jacobs, Marc, Hayakawa, Koto, Swenson, Lora, Bellon, Steven, Fleming, Mark, Taslimi, Paul, Doran, John

Volltext

Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer von Huang, Wei-Sheng, Li, Feng, Gong, Yongjin, Zhang, Yun, Youngsaye, Willmen, Xu, Yongjin, Zhu, Xiaotian, Greenfield, Matthew T., Kohlmann, Anna, Taslimi, Paul M., Toms, Angela, Zech, Stephan G., Zhou, Tianjun, Das, Biplab, Jang, Hyun G., Tugnait, Meera, Ye, Yihua E., Gonzalvez, Francois, Baker, Theresa E., Nadworny, Sara, Ning, Yaoyu, Wardwell, Scott D., Zhang, Sen, Gould, Alexandra E., Hu, Yongbo, Lane, Weston, Skene, Robert J., Zou, Hua, Clackson, Tim, Narasimhan, Narayana I., Rivera, Victor M., Dalgarno, David C., Shakespeare, William C.

Volltext

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation von Brauchle, Michael, Yao, Zhiping, Arora, Rishi, Thigale, Sachin, Clay, Ieuan, Inverardi, Bruno, Fletcher, Joy, Taslimi, Paul, Acker, Michael G, Gerrits, Bertran, Voshol, Johannes, Bauer, Andreas, Schübeler, Dirk, Bouwmeester, Tewis, Ruffner, Heinz

Volltext

Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes von Bebernitz, Gregory R, Beaulieu, Valerie, Dale, Bethany A, Deacon, Richard, Duttaroy, Alokesh, Gao, Jiaping, Grondine, Melissa S, Gupta, Ramesh C, Kakmak, Mesut, Kavana, Michael, Kirman, Louise C, Liang, Jinsheng, Maniara, Wieslawa M, Munshi, Siralee, Nadkarni, Sunil S, Schuster, Herbert F, Stams, Travis, St. Denny, Irene, Taslimi, Paul M, Vash, Brian, Caplan, Shari L

Volltext

Abstract 2644: AP32788, a potent, selective inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, in preclinical models von Gonzalvez, Francois, Zhu, Xiaotian, Huang, Wei-Sheng, Baker, Theresa E., Ning, Yaoyu, Wardwell, Scott D., Nadworny, Sara, Zhang, Sen, Das, Biplab, Gong, Yongjin, Greenfield, Matthew T., Jang, Hyun G., Kohlmann, Anna, Li, Feng, Taslimi, Paul M., Tugnait, Meera, Xu, Yongjin, Ye, Emily Y., Youngsaye, Willmen W., Zech, Stephan G., Zhang, Yun, Zhou, Tianjun, Narasimhan, Narayana I., Dalgarno, David C., Shakespeare, William C., Rivera, Victor M.

Volltext

Staurosporine-based binding assay for testing the affinity of compounds to protein kinases von Iyer, Ganesh H., Taslimi, Paul, Pazhanisamy, S.

Volltext

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models von Yamada, Ken, Levell, Julian, Yoon, Taeyong, Kohls, Darcy, Yowe, David, Rigel, Dean F, Imase, Hidetomo, Yuan, Jun, Yasoshima, Kayo, DiPetrillo, Keith, Monovich, Lauren, Xu, Lingfei, Zhu, Meicheng, Kato, Mitsunori, Jain, Monish, Idamakanti, Neeraja, Taslimi, Paul, Kawanami, Toshio, Argikar, Upendra A, Kunjathoor, Vidya, Xie, Xiaoling, Yagi, Yukiko I, Iwaki, Yuki, Robinson, Zachary, Park, Hyi-Man

Volltext

Resveratrol inhibits firefly luciferase von Bakhtiarova, Adel, Taslimi, Paul, Elliman, Stephen J., Kosinski, Penelope A., Hubbard, Brian, Kavana, Michael, Kemp, Daniel M.

Volltext

New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implicati... von Doran, John D, Liu, Xun, Taslimi, Paul, Saadat, Ahmad, Fox, Ted

Volltext

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor von Duffy, John P, Harrington, Edmund M, Salituro, Francesco G, Cochran, John E, Green, Jeremy, Gao, Huai, Bemis, Guy W, Evindar, Ghotas, Galullo, Vincent P, Ford, Pamella J, Germann, Ursula A, Wilson, Keith P, Bellon, Steven F, Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S, Wang, Yow-Ming, Murcko, Mark A, Su, Michael S.S

Volltext

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors von Cao, Jingrong, Gao, Huai, Bemis, Guy, Salituro, Francesco, Ledeboer, Mark, Harrington, Edmund, Wilke, Susanne, Taslimi, Paul, Pazhanisamy, S., Xie, Xiaoling, Jacobs, Marc, Green, Jeremy

Volltext

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK) von FARMER, Luc J, BEMIS, Guy, TER HAAR, Ernst, JIAN WANG, ZHAVERI, Darshana, SALITURO, Francesco G, BRITT, Shawn D, COCHRAN, John, CONNORS, Martin, HARRINGTON, Edmund M, HOOCK, Thomas, MARKLAND, William, NANTHAKUMAR, Suganthini, TASLIMI, Paul

Volltext

A gel sample block von Taslimi, Paul M

Volltext

A reliable, fast, and inexpensive method of preparing sucrose density gradients von Taslimi, Paul M, Kolokotronis, Demetre

Volltext

Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum von Rafati, Sima, Nakhaee, Alireza, Taheri, Tahere, Taslimi, Yasaman, Darabi, Haideh, Eravani, Davood, Sanos, Stephanie, Kaye, Paul, Taghikhani, Mohammad, Jamshidi, Shahram, Rad, Mohammad Ali

Volltext

Transdisciplinary translational science and the case of preterm birth von Stevenson, D K, Shaw, G M, Wise, P H, Norton, M E, Druzin, M L, Valantine, H A, McFarland, D A

Volltext

Multi-modality imaging assisted fluorescence-guided resection of glioblastoma: Case report von Gupta, Shaurya, Guha, Daipayan, Taslimi, Shervin, Priola, Stefano M., Waggass, Ghouth, Heyn, Chris, Graham, Simon, Foster, Stuart, Kongkham, Paul, Sinclair, John, Cook, Douglas J., Spears, Julian, Das, Sunit, Mainprize, Todd, Cusimano, Michael D., Sahgal, Arjun, Zadeh, Gelareh, Bernstein, Mark, Wilson, Brian, Kasper, Ekkehard, DeMarchi, Ryan, Murty, Naresh, Drake, Brian, Muller, Paul, Perry, James, Yang, Victor X.D.

Volltext

Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II ofL.infantum von Rafati, Sima, Nakhaee, Alireza, Taheri, Tahere, Taslimi, Yasaman, Darabi, Haideh, Eravan i, Davood, Sanos, Stephanie, Kaye, Paul, Taghikhani, Mohammad, Jamshidi, Shahram, Rad, Mohammad Ali

Volltext