Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease von Melancon, Bruce J., Tarr, James C., Panarese, Joseph D., Wood, Michael R., Lindsley, Craig W.

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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100 von BYUN, Nellie E, GRANNAN, Michael, MELANCON, Bruce J, TARR, James C, BROGAN, John T, AVISON, Malcolm J, DEUTCH, Ariel Y, WESS, Jürgen, WOOD, Michael R, LINDSLEY, Craig W, GORE, John C, CONN, P. Jeffrey, BUBSER, Michael, JONES, Carrie K, BARRY, Robert L, THOMPSON, Analisa, ROSANELLI, John, GOWRISHANKAR, Raajaram, KELM, Nathaniel D, DAMON, Stephen, BRIDGESL, Thomas M

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Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents von Bubser, Michael, Bridges, Thomas M, Dencker, Ditte, Gould, Robert W, Grannan, Michael, Noetzel, Meredith J, Lamsal, Atin, Niswender, Colleen M, Daniels, J. Scott, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Byers, Frank W, Wess, Jürgen, Duggan, Mark E, Dunlop, John, Wood, Michael W, Brandon, Nicholas J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K

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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs von Wood, Michael R, Noetzel, Meredith J, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B, Weiner, Rebecca L, Cho, Hyekyung P, Bubser, Michael, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Engers, Darren W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

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Lanthanum Tricyanide-Catalyzed Acyl Silane−Ketone Benzoin Additions von Tarr, James C, Johnson, Jeffrey S

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Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides von Tarr, James C, Wood, Michael R, Noetzel, Meredith J, Bertron, Jeanette L, Weiner, Rebecca L, Rodriguez, Alice L, Lamsal, Atin, Byers, Frank W, Chang, Sichen, Cho, Hyekyung P, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

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Enantioselective Metallophosphite-Catalyzed C-Acylation of Nitrones von Garrett, Mary R, Tarr, James C, Johnson, Jeffrey S

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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods von Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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Fragment-based screening of programmed death ligand 1 (PD-L1) von Perry, Evan, Mills, Jonathan J., Zhao, Bin, Wang, Feng, Sun, Qi, Christov, Plamen P., Tarr, James C., Rietz, Tyson A., Olejniczak, Edward T., Lee, Taekyu, Fesik, Stephen

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Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors von Tarr, James C., Salovich, James M., Aichinger, Martin, Jeon, KyuOk, Veerasamy, Nagarathanam, Sensintaffar, John L., Arnhof, Heribert, Samwer, Matthias, Christov, Plamen P., Kim, Kwangho, Wunberg, Tobias, Schweifer, Norbert, Trapani, Francesca, Arnold, Allison, Martin, Florian, Zhao, Bin, Miriyala, Nagaraju, Sgubin, Danielle, Fogarty, Stuart, Moore, William J., Stott, Gordon M., Olejniczak, Edward T., Engelhardt, Harald, Rudolph, Dorothea, Lee, Taekyu, McConnell, Darryl B., Fesik, Stephen W.

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Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia‑1 Inhibitors Using Structure-Based Design von Shaw, Subrata, Bian, Zhiguo, Zhao, Bin, Tarr, James C, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Belmar, Johannes, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Sensintaffar, John L, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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Development of a highly selective, orally bioavailable and CNS penetrant M₁ agonist derived from the MLPCN probe ML071 von Lebois, Evan P, Digby, Gregory J, Sheffler, Douglas J, Melancon, Bruce J, Tarr, James C, Cho, Hyekyung P, Miller, Nicole R, Morrison, Ryan, Bridges, Thomas M, Xiang, Zixiu, Scott Daniels, J, Wood, Michael R, Conn, P. Jeffrey, Lindsley, Craig W

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Discovery of Potent Myeloid Cell Leukemia‑1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer von Lee, Taekyu, Christov, Plamen P, Shaw, Subrata, Tarr, James C, Zhao, Bin, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Mills, Jonathan J, Bian, Zhiguo, Sensintaffar, John L, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Ramsey, Haley E, Cook, Rebecca S, Hollingshead, Melinda, Davis Millin, Myrtle, Lee, Kyung-min, Koss, Brian, Budhraja, Amit, Opferman, Joseph T, Kim, Kwangho, Arteaga, Carlos L, Moore, William J, Olejniczak, Edward T, Savona, Michael R, Fesik, Stephen W

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Targeting Selective Activation of M1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M1 Positive Allosteric Modu... von Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M, Conn, P. Jeffrey, Wood, Michael R, Lindsley, Craig W

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Discovery and biological characterization of potent myeloid cell leukemia‐1 inhibitors von Lee, Taekyu, Bian, Zhiguo, Zhao, Bin, Hogdal, Leah J., Sensintaffar, John L., Goodwin, Craig M., Belmar, Johannes, Shaw, Subrata, Tarr, James C., Veerasamy, Nagarathanam, Matulis, Shannon M., Koss, Brian, Fischer, Melissa A., Arnold, Allison L., Camper, DeMarco V., Browning, Carrie F., Rossanese, Olivia W., Budhraja, Amit, Opferman, Joseph, Boise, Lawrence H., Savona, Michael R., Letai, Anthony, Olejniczak, Edward T., Fesik, Stephen W.

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Lanthanum Tricyanide-Catalyzed Acyl Silane−Ketone Benzoin Additions and Kinetic Resolution of Resultant α-Silyloxyketones von Tarr, James C, Johnson, Jeffrey S

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Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides von Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette L., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.

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Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides von Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Melancon, Bruce J., Lamsal, Atin, Luscombe, Vincent B., Rodriguez, Alice L., Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Engers, Darren W., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.

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Challenges in the development of an M 4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides von Tarr, James C, Wood, Michael R, Noetzel, Meredith J, Melancon, Bruce J, Lamsal, Atin, Luscombe, Vincent B, Rodriguez, Alice L, Byers, Frank W, Chang, Sichen, Cho, Hyekyung P, Engers, Darren W, Jones, Carrie K, Niswender, Colleen M, Wood, Michael W, Brandon, Nicholas J, Duggan, Mark E, Conn, P Jeffrey, Bridges, Thomas M, Lindsley, Craig W

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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core von Wood, Michael R., Noetzel, Meredith J., Engers, Julie L., Bollinger, Katrina A., Melancon, Bruce J., Tarr, James C., Han, Changho, West, Mary, Gregro, Alison R., Lamsal, Atin, Chang, Sichen, Ajmera, Sonia, Smith, Emery, Chase, Peter, Hodder, Peter S., Bubser, Michael, Jones, Carrie K., Hopkins, Corey R., Emmitte, Kyle A., Niswender, Colleen M., Wood, Michael W., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.

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