CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors von Jin, Linchun, Tao, Haipeng, Karachi, Aida, Long, Yu, Hou, Alicia Y., Na, Meng, Dyson, Kyle A., Grippin, Adam J., Deleyrolle, Loic P., Zhang, Wang, Rajon, Didier A., Wang, Qiong J., Yang, James C., Kresak, Jesse L., Sayour, Elias J., Rahman, Maryam, Bova, Frank J., Lin, Zhiguo, Mitchell, Duane A., Huang, Jianping

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The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas von Mu, Luyan, Long, Yu, Yang, Changlin, Jin, Linchun, Tao, Haipeng, Ge, Haitao, Chang, Yifan E, Karachi, Aida, Kubilis, Paul S, De Leon, Gabriel, Qi, Jiping, Sayour, Elias J, Mitchell, Duane A, Lin, Zhiguo, Huang, Jianping

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269 CAR T cell production expands endogenous T cell repertoire recognizing additional tumor antigen(s) von Hou, Alicia, Jin, Linchun, Tao, Haipeng, Mitchell, Duane A, Huang, Jianping

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CAR T Cell Locomotion in Solid Tumor Microenvironment von Nguyen, Duy T, Ogando-Rivas, Elizabeth, Liu, Ruixuan, Wang, Theodore, Rubin, Jacob, Jin, Linchun, Tao, Haipeng, Sawyer, William W, Mendez-Gomez, Hector R, Cascio, Matthew, Mitchell, Duane A, Huang, Jianping, Sawyer, W Gregory, Sayour, Elias J, Castillo, Paul

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Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma von Long, Yu, Tao, Haipeng, Karachi, Aida, Grippin, Adam J, Jin, Linchun, Chang, Yifan Emily, Zhang, Wang, Dyson, Kyle A, Hou, Alicia Y, Na, Meng, Deleyrolle, Loic P, Sayour, Elias J, Rahman, Maryam, Mitchell, Duane A, Lin, Zhiguo, Huang, Jianping

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CBIO-16. DOSE INTENSIFIED TEMOZOLOMIDE IMPROVES INFILTRATION OF CD70 CAR T CELLS INTO THE GBM TUMOR MICROENVIRONMENT von Karachi, Aida, Huang, Jianping, Tao, Haipeng, Dastmalchi, Farhad, Jin, Linchun, Mitchell, Duane, Rahman, Maryam

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Product Enhanced Reverse Transcriptase for assessing replication competent virus in vectors retroviral vectors pseudotyped with GALV and VSV-G envelopes von Cornetta, Kenneth, Lin, Tsai-Yu, Tao, Haipeng, Huang, Jianping, Piskorowski, Jordon, Wilcox, Parker, Xie, Danhui, Yao, Jing, House, Kimberley, Nance, Emily, Duffy, Lisa

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IMMU-21. OVEREXPRESSING CAR T-CELL GLUCOSE TRANSPORTER TO ENHANCE ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA von Sengupta, Srabasti, Jin, Linchun, Feier, Diana, Silver, Aryeh, Chakraborty, Avirup, Tao, Haipeng, Thomas, Nagheme, Rahman, Maryam, Flores, Catherine, Castillo, Paul, Sarkisian, Matthew, Huang, Jianping, Mitchell, Duane A, Deleyrolle, Loic P

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CTIM-21. FIRST-IN-HUMAN PHASE I CLINICAL TRIAL USING 8R-70CAR T CELLS FOR NEWLY DIAGNOSED ADULT GLIOBLASTOMA von Ghiaseddin, Ashley, Tao, Haipeng, Deleyrolle, Phuong, Rahman, Maryam, Rinonos, Serendipity Zapanta, Kresak, Jesse, Massini, Tara, Hiemenz, John, robinson, Christopher, Hsu, Jack, Lin, Tuo, Wynne, Kristine, King, Jennifer, Hodik, Marcia, Lybarger, John, Manso, Eugenio Simon, Wang, Anqi, Sekora, David, McKibben, Kathryn, Dechkovskaia, Anjelika, Castillo, Paul, Ligon, John, Sayour, Elias, Deleyrolle, Loic, Mitchell, Duane, Huang, Jianping

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Bioconjugated liquid-like solid enhances characterization of solid tumor - chimeric antigen receptor T cell interactions von Nguyen, Duy T., Liu, Ruixuan, Ogando-Rivas, Elizabeth, Pepe, Alfonso, Pedro, Diego, Qdaisat, Sadeem, Nguyen, Nhi Tran Yen, Lavrador, Julia M., Golde, Griffin R., Smolchek, Ryan A., Ligon, John, Jin, Linchun, Tao, Haipeng, Webber, Alex, Phillpot, Simon, Mitchell, Duane A., Sayour, Elias J., Huang, Jianping, Castillo, Paul, Gregory Sawyer, W.

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EXTH-57. IDENTIFICATION OF NOVEL IMMUNE CHECKPOINT MOLECULE IN GLIOMA, LAIR1 von Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Jin, Linchun, Von Roemeling, Christina, Mendez-Gomez, Hector, Liu, Ruixuan, Nguyen, Duy, Hou, Alicia Y, Pepe, Alfonso, Weidert, Frances, Ghiaseddin, Ashley, Mitchell, Duane, Deleyrolle, Loic, Sayour, Elias, Sawyer, W, Tran, David, Huang, Jianping

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EXTH-58. BLOCKING IMMUNE CHECKPOINT— LAIR1: DISRUPTING THE LAIR1—FXIII-A—COLLAGEN IMMUNOSUPPRESSIVE CIRCUIT FOR ENHANCED ANTITUMOR THERAPEUTICS von Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Nguyen, Duy T, Liu, Ruixuan, Liu, Tianyi, Chakraborty, Avirup, Hou, Alicia Y, Petit, Nicole A, Von Roemeling, Christina, Lin, Tuo, Davis, Robert W, Zhang, Janie, Pepe, Alfonso, Pedro, Diego Ivan, Mendez-Gomez, Hector, Weidert, Frances, Jin, Dan, Long-James, Kaytora, Castillo, Paul C, Ligon, John A, Ghiaseddin, Ashley, Sayour, Elias J, Rahman, Maryam, Deleyrolle, Loic P, Kim, Betty Y S, Mitchell, Duane A, Sawyer, W Gregory, Huang, Jianping

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IMMU-26. RADIATION AND TEMOZOLOMIDE UP-REGULATES CD70 EXPRESSION AND ENHANCES CAR T- CELL RECOGNITION IN GBM von Na, Meng, Jin, Linchun, Tao, Haipeng, Hou, Alicia, Karachi, Aida, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

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IMMU-15. A UNIQUE SELF-STIMULATIVE PROPERTY OF CD70 CAR ADVANCES T CELL FUNCTION AND ANTI-TUMOR RESPONSE IN GLIOBLASTOMA von Jin, Linchun, Hou, Alicia, Tao, Haipeng, Karachi, Aida, Na, Meng, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

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EXTH-22. AN IND-ENABLED STUDY USING A NOVEL CHECKPOINT BLOCKADE OF LAIR1 FOR GLIOBLASTOMA THERAPY von Tao, Haipeng, Chen, Dongjiang, Yang, Changlin, Nguyen, Duy, Pepe, Alfonso, Pedro, Diego, Jin, Linchun, Liu, Ruixuan, Liu, Tianyi, Von Roemeling, Christina, Abbas, Muhammad, Hou, Alicia Y, Petit, Nicole, Abboud, Georges, Mendez-Gomez, Hector, Weidert, Frances, Jin, Dan, Long-James, Kaytora, Sayour, Elias, Deleyrolle, Loic, Gregory Sawyer, W, Mitchell, Duane, Huang, Jianping

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IMMU-38. PRECLINICAL VALIDATION AND MANUFACTURE OF IL-8 RECEPTOR-MODIFIED CD70 CAR T CELLS FOR CLINICAL TRIAL von Jin, Linchun, Tao, Haipeng, Karachi, Aida, Mendez-Gomez, Hector, Weidert, Frances, Hou, Alicia, Sayour, Elias, Mitchell, Duane, Huang, Jianping

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DRES-13. VEGF BLOCKADE ENHANCES T REGULATORY CELL FUNCTION BY DYSREGULATING GLUTAMATE TRANSPORT IN GBM von Long, Yu, Karachi, Aida, Grippin, Adam, Tao, Haipeng, Zhang, Wang, Sayour, Elias, Deleyrolle, Loic, Mitchell, Duane, Lin, Zhiguo, Huang, Jianping

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TMIC-49. ABROGATING CD70 EXPRESSION IN GBM RESULTS IN A REDUCED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT von Tao, Haipeng, Jin, Linchun, Mendez-Gomez, Hector, Long, Yu, Na, Meng, Hou, Alicia, Karachi, Aida, Lin, Zhiguo, Deleyrolle, Loic, Sayour, Elias, Mitchell, Duane, Huang, Jianping

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CD70 CXCR2-Modified CAR T-Cells Against Acute Myeloid Leukemia von Ligon, John A, Castillo, Paul, Ma, Xiaojie, Jin, Linchun, Tao, Haipeng, Nguyen, Duy, Jobin, Gabriel, Guryanova, Olga, Lamba, Jatinder K, Sawyer, W Greg, Mitchell, Duane, Mendez-Gomez, Hector, Sayour, Elias, Huang, Jianping

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IMMU-56. CXCR1/2 MODIFIED CARs CO-OPT RADIATION-INDUCED IL-8 FOR ENHANCED CHEMOTAXIS OF THE CAR T CELLS AND MAXIMAL ANTI-TUMOR EFFICACY von Jin, Linchun, Tao, Haipeng, Zhang, Wang, Long, Yu, Dyson, Kyle, Karachi, Aida, Deleyrolle, Loic, Sayour, Elias, Rahman, Maryam, Mitchell, Duane, Rajon, Didier, Yang, Changlin, Kubilis, Paul, Bova, Frank, Lin, Zhiguo, Huang, Jianping

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