Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice von Nomura, Tetsuya, Abe, Yasuhiro, Kamada, Haruhiko, Shibata, Hiroko, Kayamuro, Hiroyuki, Inoue, Masaki, Kawara, Tomoyuki, Arita, Shuhei, Furuya, Takeshi, Yamashita, Takuya, Nagano, Kazuya, Yoshikawa, Tomoaki, Yoshioka, Yasuo, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Serada, Satoshi, Naka, Tetsuji, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

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Structure–Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant von Mukai, Yohei, Shibata, Hiroko, Nakamura, Teruya, Yoshioka, Yasuo, Abe, Yasuhiro, Nomura, Tetsuya, Taniai, Madoka, Ohta, Tsunetaka, Ikemizu, Shinji, Nakagawa, Shinsaku, Tsunoda, Shin-ichi, Kamada, Haruhiko, Yamagata, Yuriko, Tsutsumi, Yasuo

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Purification and Characterization of the Human Interleukin-18 Receptor von Torigoe, Kakuji, Ushio, Shimpei, Okura, Takanori, Kobayashi, Susumu, Taniai, Madoka, Kunikata, Toshio, Murakami, Tadatoshi, Sanou, Osamu, Kojima, Hirotada, Fujii, Mitsukiyo, Ohta, Tsunetaka, Ikeda, Masao, Ikegami, Hakuo, Kurimoto, Masashi

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Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus von Fukuda, Shigeharu, Ariyasu, Toshio, Aga, Miho, Taniguchi, Mutsuko, Ariyasu, Harumi, Taniai, Madoka, Nagatomo, Daiki, Ohta, Tsunetaka

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Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window von SHIBATA, Hiroko, YOSHIOKA, Yasuo, NAKAGAWA, Shinsaku, HAYAKAWA, Takao, NAGATA, Satoshi, YAMAGATA, Yuriko, MAYUMI, Tadanori, KAMADA, Haruhiko, TSUTSUMI, Yasuo, IKEMIZU, Shinji, KOBAYASHI, Kyoko, YAMAMOTO, Yoko, MUKAI, Yohei, OKAMOTO, Takayuki, TANIAI, Madoka, KAWAMURA, Maki, ABE, Yasuhiro

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Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists von Mukai, Yohei, Nakamura, Teruya, Yoshioka, Yasuo, Shibata, Hiroko, Abe, Yasuhiro, Nomura, Tetsuya, Taniai, Madoka, Ohta, Tsunetaka, Nakagawa, Shinsaku, Tsunoda, Shin-ichi, Kamada, Haruhiko, Yamagata, Yuriko, Tsutsumi, Yasuo

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Cloning and expression of interleukin-18 binding protein von Aizawa, Yasushi, Akita, Kenji, Taniai, Madoka, Torigoe, Kakuji, Mori, Tetsuya, Nishida, Yoshihiro, Ushio, Shimpei, Nukada, Yoshiyuki, Tanimoto, Tadao, Ikegami, Hakuo, Ikeda, Masao, Kurimoto, Masashi

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The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models von Shibata, Hiroko, Yoshioka, Yasuo, Ohkawa, Akiko, Abe, Yasuhiro, Nomura, Tetsuya, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Mayumi, Tadanori, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

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Cholesteryl pullulan encapsulated TNF-[alpha] nanoparticles are an effective mucosal vaccine adjuvant against influenza virus von Nagatomo, Daiki, Taniai, Madoka, Ariyasu, Harumi, Taniguchi, Mutsuko, Aga, Miho, Ariyasu, Toshio, Ohta, Tsunetaka, Fukuda, Shigeharu

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Regulation of Candida albicans Morphogenesis by Tumor Necrosis Factor-alpha and Potential for Treatment of Oral Candidiasis von Ohta, Hitomi, Tanimoto, Tadao, Taniai, Madoka, Taniguchi, Mutsuko, Ariyasu, Toshio, Arai, Shigeyuki, Ohta, Tsunetaka, Fukuda, Shigeharu

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N-terminal amino acid sequence of a major allergen of Japanese cedar pollen ( Cry j I) von Taniai, Madoka, Ando, Shunsaku, Usui, Mitsuko, Kurimoto, Masashi, Sakaguchi, Masahiro, Inouye, Sakae, Matuhasi, Tyoku

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Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy von Yoshioka, Yasuo, Tsutsumi, Yasuo, Kamada, Haruhiko, Kihira, Tetsuya, Tsunoda, Shin-ichi, Yamamoto, Yoko, Okamoto, Takayuki, Shibata, Hiroko, Mukai, Yohei, Taniai, Madoka, Shimizu, Tomoe, Kawamura, Maki, Abe, Yasuhiro, Nakagawa, Shinsaku, Mayumi, Tadanori

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The Combination of IFN- α 2 and IFN- α 8 Exhibits Synergistic Antiproliferative Activity on Renal Cell Carcinoma (RCC) Cell Lines Through Increased Binding Affinity for IFNAR-2 von Tanimoto, Tadao, Yamamoto, Shigeto, Taniai, Madoka, Taniguchi, Mutsuko, Ariyasu, Harumi, Ushio, Chie, Aga, Miho, Mukai, Yohei, Tsutsumi, Yasuo, Ariyasu, Toshio, Ohta, Tsunetaka, Fukuda, Shigeharu

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Metastasis-Promoting Activity of a Novel Molecule, Ag 243-5, Derived from Mycoplasma, and the Complete Nucleotide Sequence von Ushio, Shimpei, Iwaki, Kanso, Taniai, Madoka, Ohta, Tsunetaka, Fukuda, Shigeharu, Sugimura, Kazuhisa, Kurimoto, Masashi

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TNFR1-selectivity improvement of mutant TNF with antagonistic activity von Nomura, Tetsuya, Abe, Yasuhiro, Inoue, Masaki, Yoshioka, Yasuo, Kayamuro, Hiroyuki, Mukai, Yohei, Taniai, Madoka, Ohta, Tsunetaka, Nakagawa, Shinsaku, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

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Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist von Shibata, Hiroko, Yoshioka, Yasuo, Ohkawa, Akiko, Minowa, Kyoko, Mukai, Yohei, Abe, Yasuhiro, Taniai, Madoka, Nomura, Tetsuya, Kayamuro, Hiroyuki, Nabeshi, Hiromi, Sugita, Toshiki, Imai, Sunao, Nagano, Kazuya, Yoshikawa, Tomoaki, Fujita, Takuya, Nakagawa, Shinsaku, Yamamoto, Akira, Ohta, Tsunetaka, Hayakawa, Takao, Mayumi, Tadanori, Vandenabeele, Peter, Aggarwal, Bharat B., Nakamura, Teruya, Yamagata, Yuriko, Tsunoda, Shin-ichi, Kamada, Haruhiko, Tsutsumi, Yasuo

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Creation of Interferon-α8 Mutants with Amino Acid Substitutions Against Interferon-α Receptor-2 Binding Sites Using Phage Display System and Evaluation of Their Biologic Properties... von Yamamoto, Kouzo, Taniai, Madoka, Torigoe, Kakuji, Yamamoto, Shigeto, Arai, Norie, Suemoto, Yasuo, Yoshida, Kenshi, Okura, Takanori, Mori, Tetsuya, Fujioka, Noboru, Tanimoto, Tadao, Miyata, Manabu, Ariyasu, Harumi, Ushio, Chie, Fujii, Mitsukiyo, Ariyasu, Toshio, Ikeda, Masao, Ohta, Tsunetaka, Kurimoto, Masashi, Fukuda, Shigeharu

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The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF von Shibata, Hiroko, Yoshioka, Yasuo, Abe, Yasuhiro, Ohkawa, Akiko, Nomura, Tetsuya, Minowa, Kyoko, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

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The therapeutic effect of TNFR1-selective antagonistic mutant TNF-a in murine hepatitis models von Shibata, Hiroko, Yoshioka, Yasuo, Ohkawa, Akiko, Abe, Yasuhiro, Nomura, Tetsuya, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Mayumi, Tadanori, Kamada, Haruhiko, Tsunoda, Shin-Ichi, Tsutsumi, Yasuo

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234 Fine tuning of receptor-selectivity for TNF using a phage display system with one-step competitive-subtractive panning von Abe, Yasuhiro, Shibata, Hiroko, Nomura, Tetsuya, Kayamuro, Hiroyuki, Mukai, Yohei, Yoshikawa, Tomoaki, Yoshioka, Yasuo, Taniai, Madoka, Ohta, Tsunetaka, Nakagawa, Shinsaku, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

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