Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b stud... von Clotet, Bonaventura, Dr, Feinberg, Judith, Prof, van Lunzen, Jan, Prof, Khuong-Josses, Marie-Aude, MD, Antinori, Andrea, MD, Dumitru, Irina, MD, Pokrovskiy, Vadim, Prof, Fehr, Jan, MD, Ortiz, Roberto, MD, Saag, Michael, Prof, Harris, Julia, MA, Brennan, Clare, DPT, Fujiwara, Tamio, PhD, Min, Sherene, MD

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Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir von QUASHIE, Peter K, MESPLEDE, Thibault, HAN, Ying-Shan, OLIVEIRA, Maureen, SINGHROY, Diane N, FUJIWARA, Tamio, UNDERWOOD, Mark R, WAINBERG, Mark A

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Pharmacokinetics and Safety of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor, in Healthy Volunteers von MIN, Sherene, SONG, Ivy, BORLAND, Julie, SHUGUANG CHEN, YU LOU, FUJIWARA, Tamio, PISCITELLI, Stephen C

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In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor von KOBAYASHI, Masanori, YOSHINAGA, Tomokazu, KAWAUCHI-MIKI, Shinobu, TAISHI, Teruhiko, KAWASUJI, Takashi, JOHNS, Brian A, UNDERWOOD, Mark R, GARVEY, Edward P, SATO, Akihiko, FUJIWARA, Tamio, SEKI, Takahiro, WAKASA-MORIMOTO, Chiaki, BROWN, Kevin W, FERRIS, Robert, FOSTER, Scott A, HAZEN, Richard J, MIKI, Shigeru, SUYAMA-KAGITANI, Akemi

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Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection von Yoshinaga, Tomokazu, Kobayashi, Masanori, Seki, Takahiro, Miki, Shigeru, Wakasa-Morimoto, Chiaki, Suyama-Kagitani, Akemi, Kawauchi-Miki, Shinobu, Taishi, Teruhiko, Kawasuji, Takashi, Johns, Brian A, Underwood, Mark R, Garvey, Edward P, Sato, Akihiko, Fujiwara, Tamio

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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore von Kawasuji, Takashi, Johns, Brian A, Yoshida, Hiroshi, Taishi, Teruhiko, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Fujiwara, Tamio

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Structure of the HIV-1 Integrase Catalytic Domain Complexed with an Inhibitor: A Platform for Antiviral Drug Design von Goldgur, Yehuda, Craigie, Robert, Cohen, Gerson H., Fujiwara, Tamio, Yoshinaga, Tomokazu, Fujishita, Toshio, Sugimoto, Hirohiko, Endo, Takeshi, Murai, Hitoshi, Davies, David R.

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The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral von GARVEY, Edward P, JOHNS, Brian A, WEATHERHEAD, Jason G, KOBLE, Cecilia S, ALIEN, Scott H, SCHALLER, Lee T, SHERRILL, Ronald G, YOSHINAGA, Tomokazu, KOBAYASHI, Masanori, WAKASA-MORIMOTO, Chiaki, MIKI, Shigeru, NAKAHARA, Koichiro, GARTLAND, Margaret J, NOSHI, Takeshi, SATO, Akihiko, FUJIWARA, Tamio, FOSTER, Scott A, MILLER, Wayne H, FERRIS, Robert G, HAZEN, Richard J, UNDERWOOD, Mark R, BOROS, Eric E, THOMPSON, James B

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Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities von Tewtrakul, Supinya, Nakamura, Norio, Hattori, Masao, Fujiwara, Tamio, Supavita, Tanomjit

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Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding von Ren, Jingshan, Nichols, Charles, Bird, Louise E., Fujiwara, Tamio, Sugimoto, Hirohiko, Stuart, David I., Stammers, David K.

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HIV-1 integrase inhibitory substances from Coleus parvifolius von Tewtrakul, Supinya, Miyashiro, Hirotsugu, Nakamura, Norio, Hattori, Masao, Kawahata, Takuya, Otake, Toru, Yoshinaga, Tomokazu, Fujiwara, Tamio, Supavita, Tanomjit, Yuenyongsawad, Supreeya, Rattanasuwon, Pranee, Dej-Adisai, Sukanya

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Synthetic jet actuator using bubbles produced by electric discharge von NISHIBE, Koichi, FUJIWARA, Tamio, OHUE, Hiroshi, TAKEZAWA, Hideki, SATO, Kotaro, YOKOTA, Kazuhiko

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Antiviral activity, safety, and pharmacokinetics/ pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1-infected adults von MIN, Sherene, SLOAN, Louis, PISCITELLI, Stephen, LALEZARI, Jay, DEJESUS, Edwin, HAWKINS, Trevor, MCCURDY, Lewis, SONG, Ivy, STRODER, Richard, SHUGUANG CHEN, UNDERWOOD, Mark, FUJIWARA, Tamio

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A Strategy for Neuraminidase Inhibitors Using Mechanism-Based Labeling Information von Hinou, Hiroshi, Miyoshi, Risho, Takasu, Yasuaki, Kai, Hirokazu, Kurogochi, Masaki, Arioka, Shingo, Gao, Xiao-Dong, Miura, Nobuaki, Fujitani, Naoki, Omoto, Shinya, Yoshinaga, Tomokazu, Fujiwara, Tamio, Noshi, Takeshi, Togame, Hiroko, Takemoto, Hiroshi, Nishimura, Shin-Ichiro

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Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase von Zhang, Chao-feng, Nakamura, Norio, Tewtrakul, Supinya, Hattori, Masao, Sun, Qi-shi, Wang, Zheng-tao, Fujiwara, Tamio

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Barrier to Resistance of Dolutegravir in Two-Drug Combinations von Yoshinaga, Tomokazu, Miki, Shigeru, Kawauchi-Miki, Shinobu, Seki, Takahiro, Fujiwara, Tamio

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Safety and Efficacy of Dolutegravir in Treatment-Experienced Subjects With Raltegravir-Resistant HIV Type 1 Infection: 24-Week Results of the VIKING Study von Eron, Joseph J., Clotet, Bonaventura, Durant, Jacques, Katlama, Christine, Kumar, Princy, Lazzarin, Adriano, Poizot-Martin, Isabelle, Richmond, Gary, Soriano, Vincent, Ait-Khaled, Mounir, Fujiwara, Tamio, Huang, Jenny, Min, Sherene, Vavro, Cindy, Yeo, Jane

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Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors von Akiyama, Toshiyuki, Johns, Brian A., Taoda, Yoshiyuki, Yoshida, Hiroshi, Taishi, Teruhiko, Kawasuji, Takashi, Murai, Hitoshi, Yoshinaga, Tomokazu, Sato, Akihiko, Seki, Takahiro, Koyama, Mikiko, Miki, Shigeru, Kawauchi-Miki, Shinobu, Kagitani-Suyama, Akemi, Fujiwara, Tamio

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Carbamoyl Pyridone HIV‑1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK12... von Johns, Brian A, Kawasuji, Takashi, Weatherhead, Jason G, Taishi, Teruhiko, Temelkoff, David P, Yoshida, Hiroshi, Akiyama, Toshiyuki, Taoda, Yoshiyuki, Murai, Hitoshi, Kiyama, Ryuichi, Fuji, Masahiro, Tanimoto, Norihiko, Jeffrey, Jerry, Foster, Scott A, Yoshinaga, Tomokazu, Seki, Takahiro, Kobayashi, Masanori, Sato, Akihiko, Johnson, Matthew N, Garvey, Edward P, Fujiwara, Tamio

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S-1153 Inhibits Replication of Known Drug-Resistant Strains of Human Immunodeficiency Virus Type 1 von FUJIWARA, T, SATO, A, SUGIMOTO, H, HATANAKA, M, HINUMA, Y, EL-FARRASH, M, MIKI, S, ABE, K, ISAKA, Y, KODAMA, M, YAMING WU, LAN BO CHEN, HARADA, H

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