Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model von Duan, Lishu, Hu, Mufeng, Tamm, Joseph A., Grinberg, Yelena Y., Shen, Fang, Chai, Yating, Xi, Hualin, Gibilisco, Lauren, Ravikumar, Brinda, Gautam, Vivek, Karran, Eric, Townsend, Matthew, Talanian, Robert V.

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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development von Biber, Knut, Bhattacharya, Anindya, Campbell, Brian M, Piro, Justin R, Rohe, Michael, Staal, Roland G W, Talanian, Robert V, Möller, Thomas

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Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis von Enari, Masato, Talanian, Robert V, Wrong, Winnie W, Nagata, Shigekazu

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Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease von Bryant, Annie, Li, Zhaozhi, Jayakumar, Rojashree, Serrano-Pozo, Alberto, Woost, Benjamin, Hu, Miwei, Woodbury, Maya E, Wachter, Astrid, Lin, Gen, Kwon, Taekyung, Talanian, Robert V, Biber, Knut, Karran, Eric H, Hyman, Bradley T, Das, Sudeshna, Bennett, Rachel E

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MEK1/2 activity modulates TREM2 cell surface recruitment von Schapansky, Jason, Grinberg, Yelena Y., Osiecki, David M., Freeman, Emily A., Walker, Stephen G., Karran, Eric, Gopalakrishnan, Sujatha M., Talanian, Robert V.

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Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease von Das, Sudeshna, Li, Zhaozhi, Wachter, Astrid, Alla, Srinija, Noori, Ayush, Abdourahman, Aicha, Tamm, Joseph A., Woodbury, Maya E., Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Serrano‐Pozo, Alberto

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Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease von Serrano-Pozo, Alberto, Li, Huan, Li, Zhaozhi, Muñoz-Castro, Clara, Jaisa-aad, Methasit, Healey, Molly A., Welikovitch, Lindsay A., Jayakumar, Rojashree, Bryant, Annie G., Noori, Ayush, Connors, Theresa R., Hu, Miwei, Zhao, Karen, Liao, Fan, Lin, Gen, Pastika, Timothy, Tamm, Joseph, Abdourahman, Aicha, Kwon, Taekyung, Bennett, Rachel E., Woodbury, Maya E., Wachter, Astrid, Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Das, Sudeshna

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Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau von Wachter, Astrid, Woodbury, Maya E., Lombardo, Sylvia, Abdourahman, Aicha, Wuest, Carolin, McGlame, Emily, Pastika, Timothy, Tamm, Joseph, Romanul, Nandini, Yanamandra, Kiran, Bennett, Rachel, Lin, Gen, Kwon, Taekyung, Liao, Fan, Klein, Corinna, Grinberg, Yelena, Jaisa-aad, Methasit, Li, Huan, Frosch, Matthew. P., Kummer, Markus P., Das, Sudeshna, Dellovade, Tammy, Karran, Eric H., Langlois, Xavier, Ried, Janina S., Serrano-Pozo, Alberto, Talanian, Robert V., Biber, Knut, Hyman, Bradley T.

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Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli von MCILROY, D, SAKAHIRA, H, TALANIAN, R. V, NAGATA, S

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Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis von Krippner-Heidenreich, Anja, Walsemann, Gesa, Beyrouthy, Maroun J., Speckgens, Stefanie, Kraft, Regine, Thole, Hubert, Talanian, Robert V., Hurt, Myra M., Lüscher, Bernhard

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Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms von Kim, Young-Myeong, Talanian, Robert V., Billiar, Timothy R.

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Sequence-Specific DNA Binding by a Short Peptide Dimer von Talanian, Robert V., McKnight, C. James, Kim, Peter S.

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Substrate Specificities of Caspase Family Proteases von Talanian, R V, Quinlan, C, Trautz, S, Hackett, M C, Mankovich, J A, Banach, D, Ghayur, T, Brady, K D, Wong, W W

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Nitric Oxide Prevents Tumor Necrosis Factor α–Induced Rat Hepatocyte Apoptosis by the Interruption of Mitochondrial Apoptotic Signaling Through S-Nitrosylation of Caspase-8 von Kim, Young-Myeong, Kim, Tae-Hyoung, Chung, Hun-Taeg, Talanian, Robert V, Yin, Xiao-Ming, Billiar, Timothy R

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Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery von Talanian, Robert V, Brady, Kenneth D, Cryns, Vincent L

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Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis von Wang, Kevin K.W., Posmantur, Rand, Nadimpalli, Ravi, Nath, Rathna, Mohan, Panaiyur, Nixon, Ralph A., Talanian, Robert V., Keegan, Martha, Herzog, Linda, Allen, Hamish

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Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) : Caspase-8 is required for TRAIL-induced apoptosis von SEOL, Dai-Wu, JIANRONG LI, SEOL, Mi-Hyang, PARK, Sang-Youel, TALANIAN, Robert V, BILLIAR, Timothy R

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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode von Argiriadi, Maria A., Ericsson, Anna M., Harris, Christopher M., Banach, David L., Borhani, David W., Calderwood, David J., Demers, Megan D., DiMauro, Jennifer, Dixon, Richard W., Hardman, Jennifer, Kwak, Silvia, Li, Biqin, Mankovich, John A., Marcotte, Douglas, Mullen, Kelly D., Ni, Baofu, Pietras, M., Sadhukhan, Ramkrishna, Sousa, Silvino, Tomlinson, Medha J., Wang, Lu, Xiang, Tao, Talanian, Robert V.

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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor von Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V

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Minimum Significant Ratio of Selectivity Ratios (MSRSR) and Confidence in Ratio of Selectivity Ratios (CRSR): Quantitative Measures for Selectivity Ratios Obtained by Screening Ass... von Goedken, Eric R., Devanarayan, Viswanath, Harris, Christopher M., Dowding, Lori A., Jakway, James P., Voss, Jeffrey W., Wishart, Neil, Jordan, David C., Talanian, Robert V.

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