Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G von Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J, Yi, Tingfang, Salvi, Nicola, Luna, Rafael E, Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H, Chorev, Michael, Halperin, Jose A, Wagner, Gerhard

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Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase von Chen, Ting, Takrouri, Khuloud, Hee-Hwang, Sung, Rana, Sandeep, Yefidoff-Freedman, Revital, Halperin, Jose, Natarajan, Amarnath, Morisseau, Christophe, Hammock, Bruce, Chorev, Michael, Aktas, Bertal H

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Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors von Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A., Aktas, Bertal H., Chorev, Michael

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New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs von Nemirovski, Alina, Vinograd, Inbal, Takrouri, Khuloud, Mijovilovich, Ana, Rompel, Annette, Gibson, Dan

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ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML von Palacino, James, Lee, Pedro, Jeong, Hangyeol, Kim, Yeonjoon, Song, Yoojin, Permpoon, Uttapol, Wong, Wesley, Bai, Chen, Fishkin, Nathan, Takrouri, Khuloud, Yu, Eunjin, Yi, Yong, Skaletskaya, Anna, Chang, Ki-Hwan, Kim, Min-Soo, Kim, Da-Yeong, Choi, Dong-Ki, Park, Peter U

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Semiautomated synthesis of a novel [ 18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats von Shalom, Eli, Takrouri, Khuloud, Metsuyanim, Nir, Grufi, Arik, Katzhendler, Jehoshua, Srebnik, Morris

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Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction von Mahalingam, Poornachandran, Takrouri, Khuloud, Chen, Ting, Sahoo, Rupam, Papadopoulos, Evangelos, Chen, Limo, Wagner, Gerhard, Aktas, Bertal H, Halperin, Jose A, Chorev, Michael

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Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to im... von Spaulding, Andrew, Takrouri, Khuloud, Mahalingam, Pornachandran, Cleary, Dillon C., Cooper, Harold D., Zucchi, Paola, Tear, Westley, Koleva, Bilyana, Beuning, Penny J., Hirsch, Elizabeth B., Aggen, James B.

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Progress Towards Addressing Gram Negative Bacterial Resistance von Koleva, Bilyana N., Takrouri, Khuloud, Cooper, Harold D., Spaulding, Andrew, Zucchi, Paola, Cleary, Dillon, Tear, Wesley, Hirsch, Elizabeth B., Aggen, James B., Beuning, Penny J.

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Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T ce... von Lim, Joanne, Skaletskaya, Anna, Permpoon, Uttapol, Kim, Yeonjoon, Saini, Shikha, Takrouri, Khuloud, Ribkovskaia, Zinaida, Bhar, Palash, Fishkin, Nathan, Choi, Dong-Ki, Park, Ji Hyun, Palacino, James, Park, Peter U.

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Abstract 2118: Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029... von Saini, Shikha, Kim, Yeonjoon, Wong, Wesley, Karunaratne, Tina, Christensen, Olaf, Dutta, Sujoy, Bhar, Palash, Takrouri, Khuloud, Fishkin, Nathan, Choi, Dong-Ki, Kim, Min-Soo, Lim, Joanne, Skaletskaya, Anna, Palacino, James, Park, Peter

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Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer von Palacino, James, Bai, Chen, Yi, Yong, Skaletskaya, Anna, Takrouri, Khuloud, Wong, Wesley, Kim, Min-Soo, Choi, Dong-Ki, Kim, Da-Young, Yang, Yeonhee, Kook, Jiae, Lee, Pedro, Jeong, Hangyeol, Jee, Sang-Mi, Park, Jiyun, Chang, Ki-Hwan, Fishkin, Nathan, Park, Peter U.

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Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction von Mahalingam, Poornachandran, Takrouri, Khuloud, Chen, Ting, Sahoo, Rupam, Papadopoulos, Evangelos, Chen, Limo, Wagner, Gerhard, Aktas, Bertal H, Halperin, Jose A, Chorev, Michael

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Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G von Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J., Yi, Tingfang, Salvi, Nicola, Luna, Rafael E., Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H., Chorev, Michael, Halperin, Jose A., Wagner, Gerhard

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Structureeactivity relationship study of 4EGI-1, small molecule eIF4E/eIF4G proteineprotein interaction inhibitors von Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H., Chorev, Michael

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Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity von Takrouri, Khuloud, Cooper, Harold D, Spaulding, Andrew, Zucchi, Paola, Koleva, Bilyana, Cleary, Dillon C, Tear, Westley, Beuning, Penny J, Hirsch, Elizabeth B, Aggen, James B

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Synthesis and Antifungal Activity of a Novel Series of Alkyldimethylamine Cyanoboranes and Their Derivatives von Takrouri, Khuloud, Oren, Gal, Polacheck, Itzhack, Sionov, Edward, Shalom, Eli, Katzhendler, Jehoshua, Srebnik, Morris

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Pharmacologically active boranes von Jabbour, Adel, Smoum, Reem, Takrouri, Khuloud, Shalom, Eli, Zaks, Batia, Steinberg, Doron, Rubinstein, Abraham, Goldberg, Israel, Katzhendler, Jehoshua, Srebnik, Morris

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C-Lithiation/Alkylation of Trimethylamine Cyanoborane von Takrouri, Khuloud, Katzhendler, Jehoshua, Srebnik, Morris

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LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES von BAI, Chen, FISHKIN, Nathan, TAKROURI, Khuloud, PARK, Peter U

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