Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72 -associated ALS or FTD von Liu, Yuanjing, Andreucci, Amy, Iwamoto, Naoki, Yin, Yuan, Yang, Hailin, Liu, Fangjun, Bulychev, Alexey, Hu, Xiao Shelley, Lin, Xuena, Lamore, Sarah, Patil, Saurabh, Mohapatra, Susovan, Purcell-Estabrook, Erin, Taborn, Kristin, Dale, Elena, Vargeese, Chandra

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Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7 von Kornecook, Thomas J., Yin, Ruoyuan, Altmann, Stephen, Be, Xuhai, Berry, Virginia, Ilch, Christopher P., Jarosh, Michael, Johnson, Danielle, Lee, Josie H., Lehto, Sonya G., Ligutti, Joseph, Liu, Dong, Luther, Jason, Matson, David, Ortuno, Danny, Roberts, John, Taborn, Kristin, Wang, Jinti, Weiss, Matthew M., Yu, Violeta, Zhu, Dawn X.D., Fremeau, Robert T., Moyer, Bryan D.

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Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis von Fleischmann, Roy, Kremer, Joel, Cush, John, Schulze-Koops, Hendrik, Connell, Carol A, Bradley, John D, Gruben, David, Wallenstein, Gene V, Zwillich, Samuel H, Kanik, Keith S

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Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS von Kandasamy, Pachamuthu, Liu, Yuanjing, Aduda, Vincent, Akare, Sandheep, Alam, Rowshon, Andreucci, Amy, Boulay, David, Bowman, Keith, Byrne, Michael, Cannon, Megan, Chivatakarn, Onanong, Shelke, Juili Dilip, Iwamoto, Naoki, Kawamoto, Tomomi, Kumarasamy, Jayakanthan, Lamore, Sarah, Lemaitre, Muriel, Lin, Xuena, Longo, Kenneth, Looby, Richard, Marappan, Subramanian, Metterville, Jake, Mohapatra, Susovan, Newman, Bridget, Paik, Ik-Hyeon, Patil, Saurabh, Purcell-Estabrook, Erin, Shimizu, Mamoru, Shum, Pochi, Standley, Stephany, Taborn, Kris, Tripathi, Snehlata, Yang, Hailin, Yin, Yuan, Zhao, Xiansi, Dale, Elena, Vargeese, Chandra

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Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers von Grubinska, B, Chen, L, Alsaloum, M, Rampal, N, Matson, DJ, Yang, C, Taborn, K, Zhang, M, Youngblood, B, Liu, D, Galbreath, E, Allred, S, Lepherd, M, Ferrando, R, Kornecook, TJ, Lehto, SG, Waxman, SG, Moyer, BD, Dib-Hajj, S, Gingras, J

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors von DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M

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P08 Preventing and managing urinary tract infections: using thematic analysis to explore interventions and strategies implemented by NHS commissioning organizations in English prim... von Sides, Eirwen, Lecky, Donna, Taborn, Esther, O’Neill, Luke, Cooper, Emily

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Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty‐Four–Month, Phase III Study... von Heijde, Désirée, Strand, Vibeke, Keystone, Edward, Kremer, Joel, Cardiel, Mario H., Cohen, Stanley, Nash, Peter, Song, Yeong‐Wook, Gruben, David, Fleischmann, Roy, Hall, Stephen, Nicholls, David, Baker, Milton F., Bessette, Louis, Haraoui, Boulos, Khraishi, Majed, Thorne, J., Birbara, Charles Allen, Baraf, Herbert Stuart Block, Bathon, Joan Marie, Brodsky, Alan Lawrence, Cush, John Joseph, Fleischmann, Roy Mitchell, Halter, Dale George, Hargrove, Jody Kay, Bouda, David William, Reddy Pasya, Suresh Kumar, Hill, Geneva Louise, Jackson, Raymond Edward, Kafka, Shelly Pearl, Kaine, Jeffrey Louis, Kempf, Kevin James, Kolba, Karen Sue, Longley, Selden, Mathews, Steven D., Misischia, Richard James, Niemer, Mark William, Palmer, William Rodney, Sayers, Michael Eugene, Schuette, Patrick Thomas, Shergy, William Julius, Sikes, David Hilton, Silverfield, Joel Charles, Taborn, James D., Wells, Alvin Francis, Wolfe, Sanford Mayer, Adhikari, Prabha, Amano, Kouichi, Bae, Sang‐Cheol, Chandrashekara, Srikantiah, Chopra, Arvind K., Hsu, Ping‐Ning, Iwahashi, Mitsuhiro, Kadel, Jugal Kishore, Kawabe, Yojiro, Koh, Eun‐Mi, Lan, Joung‐liang, Lin, Hsiao‐Yi, Liou, Lieh‐bang, Liu, Ming‐Fei, Miyasaka, Nobuyuki, Mori, Shunsuke, Park, Sung‐Hwan, Rao, Uppuluri Ramakrishna, Shim, Seung Cheol, Shobha, Vineeta, Takasaki, Yoshinari, Takeuchi, Tsutomu, Tanaka, Yoshiya, Tohma, Shigeto, Tsai, Wen‐Chan, Veeravalli, Sarath Chandra Mouli, Wagh, Shrikant, Yamanaka, Hisashi, Bichoversuska, Daniela, Goranov, Ivan, Hrytsenko, Halyna M., Kopackova, Jana, Oparanov, Boycho, Petrov, Andriy, Pokrzywnicka‐Gajek, Ines, Povoroznyuk, Vladyslav V., Ruzga, Zofia, Stanislavchuk, Mykola A., Tseluyko, Vira Iosypivna, Vitek, Petr, Freitas Zerbini, Cristiano Augusto, Cardiel‐Rios, Mario H., Escalante, William Jose Otero, Maldonado‐Lopez, Maria Concepcion, Jaller Raad, Juan Jose, Hernandez, Javier Dario Marquez, Jauregui, Edwin Antonio, Keiserman, Mauro W., Melazzi, Ana Claudia Cauceglia, Pascual‐Ramos, Virginia, Pinto, Luciana Teixeira, Radominski, Sebastiao C., Ximenes, Antonio Carlos, Morales, Sol Villegas

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Optimising antimicrobial stewardship interventions in English primary care: a behavioural analysis of qualitative and intervention studies von Borek, Aleksandra J., Wanat, Marta, Atkins, Louise, Sallis, Anna, Ashiru-Oredope, Diane, Beech, Elizabeth, Butler, Christopher C., Chadborn, Tim, Hopkins, Susan, Jones, Leah, McNulty, Cliodna A. M., Roberts, Nia, Shaw, Karen, Taborn, Esther, Tonkin-Crine, Sarah

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The role and needs of teachers/schools in infection, prevention and control post covid-19 von Ochili, R, Dyer, C, Leaver, S, Eastwood, L, Taborn, E, Brown, C, Lecky, D M

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WVE-004, an investigational stereopure antisense oligonucleotide for the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (2302) von Liu, Yuanjing, Andreucci, Amy, Iwamoto, Naoki, Yin, Yuan, Yang, Hailin, Liu, Fangjun, Patil, Saurabh, Mohapatra, Susovan, Purcell-Estabrook, Erin, Taborn, Kristin, Dale, Elena, Vargeese, Chandra

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Modulation of Ligand-Gated Glycine Receptors Via Functional Monoclonal Antibodies von Simard, Jeffrey R., Michelsen, Klaus, Wang, Yan, Yang, Chunhua, Youngblood, Beth, Grubinska, Barbara, Taborn, Kristin, Gillie, Daniel J., Cook, Kevin, Chung, Kyu, Long, Alexander M., Hall, Brian E., Shaffer, Paul L., Foti, Robert S., Gingras, Jacinthe

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How Can National Antimicrobial Stewardship Interventions in Primary Care Be Improved? A Stakeholder Consultation von Borek, Aleksandra J, Wanat, Marta, Sallis, Anna, Ashiru-Oredope, Diane, Atkins, Lou, Beech, Elizabeth, Hopkins, Susan, Jones, Leah, McNulty, Cliodna, Shaw, Karen, Taborn, Esther, Butler, Christopher, Chadborn, Tim, Tonkin-Crine, Sarah

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Three dimensional visualization and fractal analysis of mosaic patches in rat chimeras: cell assortment in liver, adrenal cortex and cornea von Iannaccone, Stephen, Zhou, Yue, Walterhouse, David, Taborn, Greg, Landini, Gabriel, Iannaccone, Philip

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Allele Selective Antisense Oligonucleotides for Reducing Mutant Huntingtin (P1.8-051) von Zhong, Zhong, Brown, Jeffrey M., Frank-Kamenetsky, Maria, Aklilu, Kidist, Dodart, Jean-Cosme, Berkovitch, Shaunna, Taborn, Kristin, Byrne, Michael, Iwamoto, Naoki, Vargeese, Chandra

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Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7 von Butler, John R., Rescourio, Gwenaella, Milgram, Benjamin C., Foti, Robert S., Kornecook, Thomas, Ligutti, Joseph, Moyer, Bryan D., Taborn, Kristin, Youngblood, Beth D., Yu, Violeta, Shimanovich, Roman, Boezio, Alessandro, Weiss, Matthew

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Stereopure Oligonucleotides for the Selective Silencing of Mutant Huntingtin (4703) von Dale, Elena, Frank-Kamenetsky, Maria, Taborn, Kristin, Aklilu, Kidist, Liu, Yuanjing, Berkovitch, Shaunna, Brown, Jeffrey, Kandasamy, Pachamuthu, Kumarasamy, Jayakanthan, Mathieu, Steven, Iwamoto, Naoki, Yin, Yuan, Yang, Hailin, Standley, Stephany, Favaloro, Frank, Longo, Kenneth, Byrne, Michael, Vargeese, Chandra

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Viv... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities von Weiss, Matthew M, Dineen, Thomas A, Marx, Isaac E, Altmann, Steven, Boezio, Alessandro, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Feric Bojic, Elma, Foti, Robert S, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Huang, Hongbing, Huang, Liyue, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, Ligutti, Joseph, La, Daniel S, Lin, Min-Hwa Jasmine, Liu, Dong, Moyer, Bryan D, Nguyen, Hanh N, Peterson, Emily A, Rose, Paul E, Taborn, Kristin, Youngblood, Beth D, Yu, Violeta, Fremeau, Robert T

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WVE‐005, a stereopure antisense oligonucleotide for MAPT silencing in tauopathies von DaleMaguire, ElenaAbbie, Guo, Lankai, Byrne, Michael, Cannon, Megan, Taborn, Kris, Prakasha, Priyanka Shiva, Longo, Kenneth, Iwamoto, Naoki, Kandasamy, Pachamuthu, Shimizu, Mamoru, Shum, Pochi, Ranade, Ashwini, Iyer, Raghuvaran, Bowman, Keith, Yang, Hailin, Yin, Yuan Benny, Liu, Fangjun, Mohapatra, Susovan, Macovei, Lilia, Patil, Saurabh, Lansita, Janice, Hu, Xiao Shelley, Smith, Karen, Goyal, Jaya, Narayanan, Padma, Rhodes, Ken, Panzara, Michael, Vargeese, Chandra

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