Why are so many MLL lysine methyltransferases required for normal mammalian development? von Crump, Nicholas T., Milne, Thomas A.

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BET inhibition disrupts transcription but retains enhancer-promoter contact von Crump, Nicholas T., Ballabio, Erica, Godfrey, Laura, Thorne, Ross, Repapi, Emmanouela, Kerry, Jon, Tapia, Marta, Hua, Peng, Lagerholm, Christoffer, Filippakopoulos, Panagis, Davies, James O. J., Milne, Thomas A.

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DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation von Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.

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Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs von O'Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J.H.F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menendez, Pablo, Milne, Thomas A., Roberts, Irene, Roy, Anindita

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A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program von Rice, Siobhan, Jackson, Thomas, Crump, Nicholas T., Fordham, Nicholas, Elliott, Natalina, O’Byrne, Sorcha, Fanego, Maria del Mar Lara, Addy, Dilys, Crabb, Trisevgeni, Dryden, Carryl, Inglott, Sarah, Ladon, Dariusz, Wright, Gary, Bartram, Jack, Ancliff, Philip, Mead, Adam J., Halsey, Christina, Roberts, Irene, Milne, Thomas A., Roy, Anindita

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MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia von Crump, Nicholas T., Smith, Alastair L., Godfrey, Laura, Dopico-Fernandez, Ana M., Denny, Nicholas, Harman, Joe R., Hamley, Joseph C., Jackson, Nicole E., Chahrour, Catherine, Riva, Simone, Rice, Siobhan, Kim, Jaehoon, Basrur, Venkatesha, Fermin, Damian, Elenitoba-Johnson, Kojo, Roeder, Robert G., Allis, C. David, Roberts, Irene, Roy, Anindita, Geng, Huimin, Davies, James O. J., Milne, Thomas A.

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Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP von Crump, Nicholas T, Hazzalin, Catherine A, Bowers, Erin M, Alani, Rhoda M, Cole, Philip A, Mahadevan, Louis C

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Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia von Schneider, Pauline, Crump, Nicholas T, Arentsen-Peters, Susan T C J M, Smith, Alastair L, Hagelaar, Rico, Adriaanse, Fabienne R S, Bos, Romy S, de Jong, Anja, Nierkens, Stefan, Koopmans, Bianca, Milne, Thomas A, Pieters, Rob, Stam, Ronald W

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Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition von Dancy, Beverley M., Crump, Nicholas T., Peterson, Daniel J., Mukherjee, Chandrani, Bowers, Erin M., Ahn, Young-Hoon, Yoshida, Minoru, Zhang, Jin, Mahadevan, Louis C., Meyers, David J., Boeke, Jef D., Cole, Philip A.

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H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells von Godfrey, Laura, Crump, Nicholas T., O’Byrne, Sorcha, Lau, I-Jun, Rice, Siobhan, Harman, Joe R., Jackson, Thomas, Elliott, Natalina, Buck, Gemma, Connor, Christopher, Thorne, Ross, Knapp, David J. H. F., Heidenreich, Olaf, Vyas, Paresh, Menendez, Pablo, Inglott, Sarah, Ancliff, Philip, Geng, Huimin, Roberts, Irene, Roy, Anindita, Milne, Thomas A.

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A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes von Harman, Joe R, Thorne, Ross, Jamilly, Max, Tapia, Marta, Crump, Nicholas T, Rice, Siobhan, Beveridge, Ryan, Morrissey, Edward, de Bruijn, Marella F T R, Roberts, Irene, Roy, Anindita, Fulga, Tudor A, Milne, Thomas A

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Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax von Fidyt, Klaudyna, Pastorczak, Agata, Cyran, Julia, Crump, Nicholas T., Goral, Agnieszka, Madzio, Joanna, Muchowicz, Angelika, Poprzeczko, Martyna, Domka, Krzysztof, Komorowski, Lukasz, Winiarska, Magdalena, Harman, Joe R., Siudakowska, Karolina, Graczyk-Jarzynka, Agnieszka, Patkowska, Elzbieta, Lech-Maranda, Ewa, Mlynarski, Wojciech, Golab, Jakub, Milne, Thomas A., Firczuk, Malgorzata

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Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation von Crump, Nicholas T., Hadjinicolaou, Andreas V., Xia, Meng, Walsby-Tickle, John, Gileadi, Uzi, Chen, Ji-Li, Setshedi, Mashiko, Olsen, Lars R., Lau, I-Jun, Godfrey, Laura, Quek, Lynn, Yu, Zhanru, Ballabio, Erica, Barnkob, Mike B., Napolitani, Giorgio, Salio, Mariolina, Koohy, Hashem, Kessler, Benedikt M., Taylor, Stephen, Vyas, Paresh, McCullagh, James S.O., Milne, Thomas A., Cerundolo, Vincenzo

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Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart von Hulikova, Alzbeta, Park, Kyung Chan, Loonat, Aminah A., Gunadasa-Rohling, Mala, Curtis, M. Kate, Chung, Yu Jin, Wilson, Abigail, Carr, Carolyn A., Trafford, Andrew W., Fournier, Marjorie, Moshnikova, Anna, Andreev, Oleg A., Reshetnyak, Yana K., Riley, Paul R., Smart, Nicola, Milne, Thomas A., Crump, Nicholas T., Swietach, Pawel

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Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor von Bowers, Erin M., Yan, Gai, Mukherjee, Chandrani, Orry, Andrew, Wang, Ling, Holbert, Marc A., Crump, Nicholas T., Hazzalin, Catherine A., Liszczak, Glen, Yuan, Hua, Larocca, Cecilia, Saldanha, S. Adrian, Abagyan, Ruben, Sun, Yan, Meyers, David J., Marmorstein, Ronen, Mahadevan, Louis C., Alani, Rhoda M., Cole, Philip A.

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Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation von Park, Kyung Chan, Crump, Nicholas T, Louwman, Niamh, Krywawych, Steve, Cheong, Yuen Jian, Vendrell, Iolanda, Gill, Eleanor K, Gunadasa-Rohling, Mala, Ford, Kerrie L, Hauton, David, Fournier, Marjorie, Pires, Elisabete, Watson, Lydia, Roseman, Gerald, Holder, James, Koschinski, Andreas, Carnicer, Ricardo, Curtis, M Kate, Zaccolo, Manuela, Hulikova, Alzbeta, Fischer, Roman, Kramer, Holger B, McCullagh, James S O, Trefely, Sophie, Milne, Thomas A, Swietach, Pawel

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P332: LIN28B: AN IMPORTANT ONCO‐FETAL GENE IN INFANT ACUTE LYMPHOBLASTIC LEUKAEMIA von Ling, Rebecca, Jackson, Thomas, Elliott, Natalina, Cross, Joe, Rice, Siobhan, Howitt, Rebecca, Smith, Alastair, Harman, Joe, T Crump, Nicholas, Wang, Guanlin, Iskander, Deena, Thongjuea, Supat, Ancliff, Philip, Psaila, Beth, Roberts, Irene, Milne, Thomas, Roy, Anindita

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Reconstitution and Analysis of the Multienzyme Escherichia coli RNA Degradosome von Worrall, Jonathan A.R., Górna, Maria, Crump, Nicholas T., Phillips, Lara G., Tuck, Alex C., Price, Amanda J., Bavro, Vassiliy N., Luisi, Ben F.

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Cover Picture: Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition (ChemBioChem 14/2012) von Dancy, Beverley M., Crump, Nicholas T., Peterson, Daniel J., Mukherjee, Chandrani, Bowers, Erin M., Ahn, Young-Hoon, Yoshida, Minoru, Zhang, Jin, Mahadevan, Louis C., Meyers, David J., Boeke, Jef D., Cole, Philip A.

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Establishment and Characterization of a Model of Acquired Resistance to DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic Leukemia Cells von Schneider, Pauline, Arentsen-Peters, Susan T.C.J.M., Crump, Nicholas T., Smith, Alastair, Hagelaar, Rico, Adriaanse, Fabienne R.S., Bos, Romy S., Vrenken, Kirsten S., rockx-Brouwer, Dedeke, Tang, Ziqin, Vermeij, Wilbert P., De Jong, Anja, Koopmans, Bianca, Dolman, M.Emmy M., Milne, Thomas A., Pieters, Rob, Stam, Ronald W.

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