Toward the standardization of bioinformatics methods for the accurate assessment of tumor mutational burden (TMB) von Chang, H., Srinivasan, S., Sasson, A., Golhar, R., Greenawalt, D., Kirov, S., Szustakowski, J.D.

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Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden von Hellmann, Matthew D, Ciuleanu, Tudor-Eliade, Pluzanski, Adam, Lee, Jong Seok, Otterson, Gregory A, Audigier-Valette, Clarisse, Minenza, Elisa, Linardou, Helena, Burgers, Sjaak, Salman, Pamela, Borghaei, Hossein, Ramalingam, Suresh S, Brahmer, Julie, Reck, Martin, O’Byrne, Kenneth J, Geese, William J, Green, George, Chang, Han, Szustakowski, Joseph, Bhagavatheeswaran, Prabhu, Healey, Diane, Fu, Yali, Nathan, Faith, Paz-Ares, Luis

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Computational identification of operons in microbial genomes von Zheng, Yu, Szustakowski, Joseph D, Fortnow, Lance, Roberts, Richard J, Kasif, Simon

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Protein structure alignment using a genetic algorithm von Szustakowski, Joseph D., Weng, Zhiping

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Less is more: towards an optimal universal description of protein folds von Szustakowski, Joseph D., Kasif, Simon, Weng, Zhiping

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69PToward the standardization of bioinformatics methods for the accurate assessment of tumor mutational burden (TMB) von Chang, H, Srinivasan, S, Sasson, A, Golhar, R, Greenawalt, D, Kirov, S, Szustakowski, J D

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Identification of novel pathway regulation during myogenic differentiation von Szustakowski, Joseph D., Lee, Jee-Hyung, Marrese, Christine A., Kosinski, Penelope A., Nirmala, N.R., Kemp, Daniel M.

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P086 Toward the Standardization of Bioinformatics Methods for the Accurate Assessment of Tumor Mutational Burden (TMB) von Chang, H., Srinivasan, S., Sasson, A., Golhar, R., Greenawalt, D., Kirov, S., Szustakowski, J., Ip, V.

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Bioinformatics Analysis of Microarray Data von Zhang, Yunyu, Szustakowski, Joseph, Schinke, Martina

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Identification of human mutations in TRAF3IP1 in patients with nephronophthisis and retinal degeneration von Becker-Heck, A, Bizet, A, Ryan, R, Krug, P, Filhol, E, Linghu, B, Oakeley, E, Serluca, F, Legendre, F, Dörner, N, Lasbennes, MC, Duca, J, Yang, F, Damask, A, Klickstein, L, Labow, M, Schebesta, M, Bouwmeester, T, Valette, H, Pinson, L, Goubaux, B, Dubot, P, Salomon, R, Antignac, C, Gubler, M, Jeanpierre, C, Chibout, S, Bole-Feysot, C, Nitschké, P, Benmerah, A, Szustakowski, JD, Sailer, AW, Saunier, S, Saint-Mezard, P

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Estrogen-related receptor α is essential for the expression of antioxidant protection genes and mitochondrial function von Rangwala, Shamina M., Li, Xiaoyan, Lindsley, Loren, Wang, Xiaomei, Shaughnessy, Stacey, Daniels, Thomas G., Szustakowski, Joseph, Nirmala, N.R., Wu, Zhidan, Stevenson, Susan C.

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Clustering protein sequences with a novel metric transformed from sequence similarity scores and sequence alignments with neural networks von Ma, Qicheng, Chirn, Gung-Wei, Cai, Richard, Szustakowski, Joseph D, Nirmala, N R

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First-Line Nivolumab Plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer (CheckMate 568): Outcomes by Programmed Death Ligand 1 and Tumor Mutational Burden as Biomarkers von Ready, Neal, Hellmann, Matthew D, Awad, Mark M, Otterson, Gregory A, Gutierrez, Martin, Gainor, Justin F, Borghaei, Hossein, Jolivet, Jacques, Horn, Leora, Mates, Mihaela, Brahmer, Julie, Rabinowitz, Ian, Reddy, Pavan S, Chesney, Jason, Orcutt, James, Spigel, David R, Reck, Martin, O'Byrne, Kenneth John, Paz-Ares, Luis, Hu, Wenhua, Zerba, Kim, Li, Xuemei, Lestini, Brian, Geese, William J, Szustakowski, Joseph D, Green, George, Chang, Han, Ramalingam, Suresh S

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Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer von Hellmann, Matthew D., Callahan, Margaret K., Awad, Mark M., Calvo, Emiliano, Ascierto, Paolo A., Atmaca, Akin, Rizvi, Naiyer A., Hirsch, Fred R., Selvaggi, Giovanni, Szustakowski, Joseph D., Sasson, Ariella, Golhar, Ryan, Vitazka, Patrik, Chang, Han, Geese, William J., Antonia, Scott J.

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Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer von Hellmann, Matthew D., Callahan, Margaret K., Awad, Mark M., Calvo, Emiliano, Ascierto, Paolo A., Atmaca, Akin, Rizvi, Naiyer A., Hirsch, Fred R., Selvaggi, Giovanni, Szustakowski, Joseph D., Sasson, Ariella, Golhar, Ryan, Vitazka, Patrik, Chang, Han, Geese, William J., Antonia, Scott J.

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Plasma proteomic associations with genetics and health in the UK Biobank von Sun, Benjamin B., Chiou, Joshua, Traylor, Matthew, Benner, Christian, Hsu, Yi-Hsiang, Richardson, Tom G., Surendran, Praveen, Mahajan, Anubha, Robins, Chloe, Vasquez-Grinnell, Steven G., Hou, Liping, Kvikstad, Erika M., Burren, Oliver S., Davitte, Jonathan, Ferber, Kyle L., Gillies, Christopher E., Hedman, Åsa K., Hu, Sile, Lin, Tinchi, Mikkilineni, Rajesh, Pendergrass, Rion K., Pickering, Corran, Prins, Bram, Baird, Denis, Chen, Chia-Yen, Ward, Lucas D., Deaton, Aimee M., Welsh, Samantha, Willis, Carissa M., Lehner, Nick, Arnold, Matthias, Wörheide, Maria A., Suhre, Karsten, Kastenmüller, Gabi, Sethi, Anurag, Cule, Madeleine, Raj, Anil, Burkitt-Gray, Lucy, Melamud, Eugene, Black, Mary Helen, Fauman, Eric B., Howson, Joanna M. M., Kang, Hyun Min, McCarthy, Mark I., Nioi, Paul, Petrovski, Slavé, Scott, Robert A., Smith, Erin N., Szalma, Sándor, Waterworth, Dawn M., Mitnaul, Lyndon J., Szustakowski, Joseph D., Gibson, Bradford W., Miller, Melissa R., Whelan, Christopher D.

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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction von Wells, Daniel K., Dang, Kristen K., Sheehan, Kathleen C.F., Campbell, Katie M., Lamb, Andrew, Ward, Jeffrey P., Sidney, John, Blazquez, Ana B., Rech, Andrew J., Zaretsky, Jesse M., Ng, Alphonsus H.C., Yu, Thomas V., Manning, Patrice, Steiner, Gabriela M., Khan, Aly A., Lugade, Amit, Frentzen, Angela A. Elizabeth, Tadmor, Arbel D., Sasson, Ariella S., Rao, Arjun A., Pei, Baikang, Schrörs, Barbara, Peters, Bjoern, Li, Bo, Stevenson, Brian J., Iseli, Christian, Morehouse, Christopher A., Melief, Cornelis J.M., Puig-Saus, Cristina, van Beek, Daphne, Balli, David, Gfeller, David, Haussler, David, Jäger, Dirk, Cortes, Eduardo, Esaulova, Ekaterina, Sherafat, Elham, Bartha, Gabor, Liu, Geng, Coukos, George, Xenarios, Ioannis, Mandoiu, Ion, Kooi, Irsan, Kessler, Jan H., Greenbaum, Jason A., Perera, Jason F., Harris, Jason, Hundal, Jasreet, Shelton, Jennifer M., Wang, Jianmin, Wang, Jiaqian, Szustakowski, Joseph, Kodysh, Julia, Forman, Juliet, Wei, Lei, Lee, Leo J., Slagter, Maarten, Mueller, Markus, Lower, Martin, Vormehr, Mathias, Artyomov, Maxim N., Yang, Naibo, Raicevic, Nevena M. Ilic, Guex, Nicolas, Robine, Nicolas, Halama, Niels, Skundric, Nikola M., Milicevic, Ognjen S., Gellert, Pascal, Jongeneel, Patrick, Charoentong, Pornpimol, Tanden, Prateek, Hu, Qiang, Gupta, Ravi, Petit, Robert, Ziman, Robert, Hilker, Rolf, Shukla, Sachet A., Boyle, Sean M., Qiu, Si, Salama, Sofie, Liu, Song, Wu, Song, Ketelaars, Steven L.C., Jhunjhunwala, Suchit, Shcheglova, Tatiana, Schuepbach, Thierry, Creasy, Todd H., Kovacevic, Vladimir B., Krebber, Willem-Jan, Sebastian, Yinong, Yalcin, Zeynep Kosaloglu, Selinsky, Cheryl, Ribas, Antoni, Hellmann, Matthew D., Hacohen, Nir, Sette, Alessandro, Heath, James R., Schreiber, Robert D., Kvistborg, Pia

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Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank von Szustakowski, Joseph D., Balasubramanian, Suganthi, Kvikstad, Erika, Khalid, Shareef, Bronson, Paola G., Sasson, Ariella, Wong, Emily, Liu, Daren, Wade Davis, J., Haefliger, Carolina, Katrina Loomis, A., Mikkilineni, Rajesh, Noh, Hyun Ji, Wadhawan, Samir, Bai, Xiaodong, Hawes, Alicia, Krasheninina, Olga, Ulloa, Ricardo, Lopez, Alex E., Smith, Erin N., Waring, Jeffrey F., Whelan, Christopher D., Tsai, Ellen A., Overton, John D., Salerno, William J., Jacob, Howard, Szalma, Sandor, Runz, Heiko, Hinkle, Gregory, Nioi, Paul, Petrovski, Slavé, Miller, Melissa R., Baras, Aris, Mitnaul, Lyndon J., Reid, Jeffrey G.

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Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization von Bizet, Albane A., Becker-Heck, Anita, Ryan, Rebecca, Weber, Kristina, Filhol, Emilie, Krug, Pauline, Halbritter, Jan, Delous, Marion, Lasbennes, Marie-Christine, Linghu, Bolan, Oakeley, Edward J., Zarhrate, Mohammed, Nitschké, Patrick, Garfa-Traore, Meriem, Serluca, Fabrizio, Yang, Fan, Bouwmeester, Tewis, Pinson, Lucile, Cassuto, Elisabeth, Dubot, Philippe, Elshakhs, Neveen A. Soliman, Sahel, José A., Salomon, Rémi, Drummond, Iain A., Gubler, Marie-Claire, Antignac, Corinne, Chibout, Salahdine, Szustakowski, Joseph D., Hildebrandt, Friedhelm, Lorentzen, Esben, Sailer, Andreas W., Benmerah, Alexandre, Saint-Mezard, Pierre, Saunier, Sophie

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LMX1B Mutations Cause Hereditary FSGS without Extrarenal Involvement von BOYER, Olivia, WOERNER, Stéphanie, SZUSTAKOWSKI, Joseph D, HEIBEL, Françoise, MATIGNON, Marie, BAUDOUIN, Véronique, CHANTREL, François, CHAMPIGNEULLE, Jacqueline, MARTIN, Laurent, NITSCHKE, Patrick, GUBLER, Marie-Claire, JOHNSON, Keith J, FAN YANG, CHIBOUT, Salah-Dine, ANTIGNAC, Corinne, OAKELEY, Edward J, LINGHU, Bolan, GRIBOUVAL, Olivier, TETE, Marie-Josèphe, DUCA, José S, KLICKSTEIN, Lloyd, DAMASK, Amy J

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