Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond von Chaudhuri, Shuvam, Symons, Julian A., Deval, Jerome

Volltext

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase von Jordan, Paul C, Liu, Cheng, Raynaud, Pauline, Lo, Michael K, Spiropoulou, Christina F, Symons, Julian A, Beigelman, Leo, Deval, Jerome

Volltext

Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results von Oey, Abbie, McClure, Matthew, Symons, Julian A, Chanda, Sushmita, Fry, John, Smith, Patrick F, Luciani, Kathia, Fayon, Michael, Chokephaibulkit, Kulkanya, Uppala, Rattapon, Bernatoniene, Jolanta, Furuno, Kenji, Stanley, Thorsten, Huntjens, Dymphy, Witek, James

Volltext

Regulation of gene transcription by thyroid hormone receptor beta agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) von Luong, Xuan G., Stevens, Sarah K., Jekle, Andreas, Lin, Tse, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M., Beigelman, Leonid N., Symons, Julian A., Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome

Volltext

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir von Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K, De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M, Beigelman, Leonid, Symons, Julian A, Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen

Volltext

Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study von DeVincenzo, John P, McClure, Matthew W, Symons, Julian A, Fathi, Hosnieh, Westland, Christopher, Chanda, Sushmita, Lambkin-Williams, Rob, Smith, Patrick, Zhang, Qingling, Beigelman, Leo, Blatt, Lawrence M, Fry, John

Volltext

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate von Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo

Volltext

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry von Gurard-Levin, Zachary A., Liu, Cheng, Jekle, Andreas, Jaisinghani, Ruchika, Ren, Suping, Vandyck, Koen, Jochmans, Dirk, Leyssen, Pieter, Neyts, Johan, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Scholle, Michael D., Deval, Jerome

Volltext

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Vir... von Wang, Guangyi, Deval, Jerome, Hong, Jin, Dyatkina, Natalia, Prhavc, Marija, Taylor, Joshua, Fung, Amy, Jin, Zhinan, Stevens, Sarah K, Serebryany, Vladimir, Liu, Jyanwei, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita M, Smith, David B, Symons, Julian A, Blatt, Lawrence M, Beigelman, Leo

Volltext

Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus von Deval, Jerome, Symons, Julian A, Beigelman, Leo

Volltext

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model von Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan

Volltext

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase von Deval, Jerome, Fung, Amy, Stevens, Sarah K, Jordan, Paul C, Gromova, Tatiana, Taylor, Joshua S, Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A, Beigelman, Leo

Volltext

Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation von Kum, Dieudonné Buh, Vanrusselt, Hannah, Acosta Sanchez, Abel, Taverniti, Valerio, Verrier, Eloi R, Baumert, Thomas F, Liu, Cheng, Deval, Jerome, Corthout, Nikky, Munck, Sebastian, Beigelman, Leonid, Blatt, Lawrence M, Symons, Julian A, Raboisson, Pierre, Jekle, Andreas, Vendeville, Sandrine, Debing, Yannick

Volltext

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development von Liu, Cheng, Boland, Sandro, Scholle, Michael D., Bardiot, Dorothee, Marchand, Arnaud, Chaltin, Patrick, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Gurard-Levin, Zachary A., Vandyck, Koen, Deval, Jerome

Volltext

Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs von Jin, Zhinan, Kinkade, April, Behera, Ishani, Chaudhuri, Shuvam, Tucker, Kathryn, Dyatkina, Natalia, Rajwanshi, Vivek K., Wang, Guangyi, Jekle, Andreas, Smith, David B., Beigelman, Leo, Symons, Julian A., Deval, Jerome

Volltext

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues von Wang, Guangyi, Wan, Jinqiao, Hu, Yujian, Wu, Xiangyang, Prhavc, Marija, Dyatkina, Natalia, Rajwanshi, Vivek K, Smith, David B, Jekle, Andreas, Kinkade, April, Symons, Julian A, Jin, Zhinan, Deval, Jerome, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita, Blatt, Lawrence, Beigelman, Leonid

Volltext

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles von Vanrusselt, Hannah, Kum, Dieudonné Buh, Taverniti, Valerio, Liu, Cheng, Acosta Sanchez, Abel, Corthout, Nikky, Munck, Sebastian, Baumert, Thomas F, Beigelman, Leonid, Blatt, Lawrence M, Symons, Julian A, Deval, Jerome, Raboisson, Pierre, Verrier, Eloi R, Jekle, Andreas, Vendeville, Sandrine, Debing, Yannick

Volltext

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models von Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K, Stoycheva, Antitsa, Rajwanshi, Vivek K, Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B, Blatt, Lawrence M, Symons, Julian A, Gonzalvez, Francois, Beigelman, Leonid

Volltext

Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH von Vandyck, Koen, McGowan, David C, Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Gupta, Kusum, Misner, Dinah L, Chanda, Sushmita, Serebryany, Vladimir, Welch, Michael, Hu, Haiyang, Lv, Zhidan, Williams, Caroline, Maskos, Klaus, Lammens, Alfred, Stoycheva, Antitsa D, Lin, Tse-I, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, Deval, Jerome

Volltext

Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study von Yogaratnam, Jeysen, Rito, Jennifer, Kakuda, Thomas N, Fennema, Hein, Gupta, Kusum, Jekle, C Andreas, Mitchell, Toni, Boyce, Malcolm, Sahgal, Omair, Balaratnam, Ganesh, Chanda, Sushmita, Van Remoortere, Pieter, Symons, Julian A, Fry, John

Volltext