Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment von Kfoury, Youmna, Baryawno, Ninib, Severe, Nicolas, Mei, Shenglin, Gustafsson, Karin, Hirz, Taghreed, Brouse, Thomas, Scadden, Elizabeth W., Igolkina, Anna A., Kokkaliaris, Konstantinos, Choi, Bryan D., Barkas, Nikolas, Randolph, Mark A., Shin, John H., Saylor, Philip J., Scadden, David T., Sykes, David B., Kharchenko, Peter V.

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Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses von Hirz, Taghreed, Mei, Shenglin, Sarkar, Hirak, Kfoury, Youmna, Wu, Shulin, Verhoeven, Bronte M., Subtelny, Alexander O., Zlatev, Dimitar V., Wszolek, Matthew W., Salari, Keyan, Murray, Evan, Chen, Fei, Macosko, Evan Z., Wu, Chin-Lee, Scadden, David T., Dahl, Douglas M., Baryawno, Ninib, Saylor, Philip J., Kharchenko, Peter V., Sykes, David B.

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Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance von van Gastel, Nick, Spinelli, Jessica B., Sharda, Azeem, Schajnovitz, Amir, Baryawno, Ninib, Rhee, Catherine, Oki, Toshihiko, Grace, Eliane, Soled, Heather J., Milosevic, Jelena, Sykes, David B., Hsu, Peggy P., Vander Heiden, Matthew G., Vidoudez, Charles, Trauger, Sunia A., Haigis, Marcia C., Scadden, David T.

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A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma von Alchahin, Adele M., Mei, Shenglin, Tsea, Ioanna, Hirz, Taghreed, Kfoury, Youmna, Dahl, Douglas, Wu, Chin-Lee, Subtelny, Alexander O., Wu, Shulin, Scadden, David T., Shin, John H., Saylor, Philip J., Sykes, David B., Kharchenko, Peter V., Baryawno, Ninib

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Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8 von Kamps, Mark P, Wang, Gang G, Calvo, Katherine R, Pasillas, Martina P, Sykes, David B, Häcker, Hans

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Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells von Kalaitzidis, Demetrios, Lee, Dongjun, Efeyan, Alejo, Kfoury, Youmna, Nayyar, Naema, Sykes, David B, Mercier, Francois E, Papazian, Ani, Baryawno, Ninib, Victora, Gabriel D, Neuberg, Donna, Sabatini, David M, Scadden, David T

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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions von Mei, Shenglin, Alchahin, Adele M, Tsea, Ioanna, Kfoury, Youmna, Hirz, Taghreed, Jeffries, Nathan Elias, Zhao, Ting, Xu, Yanxin, Zhang, Hanyu, Sarkar, Hirak, Wu, Shulin, Subtelny, Alexander O, Johnsen, John Inge, Zhang, Yida, Salari, Keyan, Wu, Chin-Lee, Randolph, Mark A, Scadden, David T, Dahl, Douglas M, Shin, John, Kharchenko, Peter V, Saylor, Philip J, Sykes, David B, Baryawno, Ninib

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DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma von Olsen, Thale Kristin, Dyberg, Cecilia, Embaie, Bethel Tesfai, Alchahin, Adele, Milosevic, Jelena, Ding, Jane, Otte, Jörg, Tümmler, Conny, Hed Myrberg, Ida, Westerhout, Ellen M, Koster, Jan, Versteeg, Rogier, Ding, Han-Fei, Kogner, Per, Johnsen, John Inge, Sykes, David B, Baryawno, Ninib

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Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature von Mei, Shenglin, Alchahin, Adele M, Embaie, Bethel Tesfai, Gavriliuc, Ioana Maria, Verhoeven, Bronte Manouk, Zhao, Ting, Li, Xiangyun, Jeffries, Nathan Elias, Pepich, Adena, Sarkar, Hirak, Olsen, Thale Kristin, Wickström, Malin, Stenman, Jakob, Reina-Bedoya, Oscar, Kharchenko, Peter V, Saylor, Philip J, Johnsen, John Inge, Sykes, David B, Kogner, Per, Baryawno, Ninib

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Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retrovira... von CALVO, Katherine R, SYKES, David B, PASILLAS, Martina P, KAMPS, Mark P

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A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma von Alchahin, AM, Mei, SL, Tsea, I, Hirz, T, Kfoury, Y, Dahl, D, Wu, CL, Subtelny, AO, Wu, SL, Scadden, DT, Shin, JH, Saylor, PJ, Sykes, DB, Kharchenko, PV, Baryawno, N

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Meis1a Suppresses Differentiation by G-CSF and Promotes Proliferation by SCF: Potential Mechanisms of Cooperativity with Hoxa9 in Myeloid Leukemia von Calvo, Katherine R., Knoepfler, Paul S., Sykes, David B., Pasillas, Martina P., Kamps, Mark P.

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Hoxa9 Immortalizes a Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Promyelocyte Capable of Biphenotypic Differentiation to Neutrophils or Macrophages, Independent of E... von Calvo, Katherine R., Sykes, David B., Pasillas, Martina, Kamps, Mark P.

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An Induced Ets Repressor Complex Regulates Growth Arrest during Terminal Macrophage Differentiation von Klappacher, Günter W., Lunyak, Victoria V., Sykes, David B., Sawka-Verhelle, Dominique, Sage, Julien, Brard, Gyan, Ngo, Sally D., Gangadharan, Denise, Jacks, Tyler, Kamps, Mark P., Rose, David W., Rosenfeld, Michael G., Glass, Christopher K.

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Impact of metastatic prostate cancer on human bone marrow von Baryawno, N, Kfoury, Y, Severe, N, Mei, SL, Gustafsson, K, Hirz, T, Brouse, T, Scadden, EW, Igolkina, AA, Choi, BD, Barkas, N, Shin, JH, Saylor, PJ, Scadden, DT, Sykes, DB, Kharchenko, PV

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E2a/Pbx1 Induces the Rapid Proliferation of Stem Cell Factor-Dependent Murine Pro-T Cells That Cause Acute T-Lymphoid or Myeloid Leukemias in Mice von Sykes, David B., Kamps, Mark P.

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HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation von KNOEPFLER, Paul S, SYKES, David B, PASILLAS, Martina, KAMPS, Mark P

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Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins von Sykes, David B., Kamps, Mark P.

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Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy von Breen, Christopher M, Sykes, Destiny B, Baehr, Carsten, Fricker, Gert, Miller, David S

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The HoxB1 hexapeptide is a prefolded domain: Implications for the Pbx1/Hox interaction von Slupsky, Carolyn M., Sykes, David B., Gay, Grant L., Sykes, Brian D.

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