Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines von Swinney, D C

Volltext

Challenges and Hurdles to Business as Usual in Drug Development for Treatment of Rare Diseases von Swinney, DC

Volltext

Biochemical mechanisms of drug action: what does it take for success? von Swinney, David C

Volltext

Targeting protein ubiquitination for drug discovery. What is in the drug discovery toolbox? von Swinney, David C

Volltext

Stereoisomers of ketoconazole: preparation and biological activity von Rotstein, David M, Kertesz, Denis J, Walker, Keith A. M, Swinney, David C

Volltext

Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P-450 isozymes von Swinney, D. C, Ryan, D. E, Thomas, P. E, Levin, W

Volltext

Differential Allosteric Regulation of Prostaglandin H Synthase 1 and 2 by Arachidonic Acid von Swinney, D C, Mak, A Y, Barnett, J, Ramesha, C S

Volltext

Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX von Tsai, A l, Palmer, G, Xiao, G, Swinney, D C, Kulmacz, R J

Volltext

Azalanstat (RS-21607), a lanosterol 14α-demethylase inhibitor with cholesterol-lowering activity von Burton, Pamela M., Swinney, David C., Heller, Renu, Dunlap, Bonnie, Chiou, Melody, Malonzo, Edna, Haller, Judy, Walker, Keith A.M., Salari, Amid, Murakami, Stanley, Mendizabal, Gregory, Tokes, Laszlo

Volltext

The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation von So, O Y, Scarafia, L E, Mak, A Y, Callan, O H, Swinney, D C

Volltext

Mechanism of androstenedione formation from testosterone and epitestosterone catalyzed by purified cytochrome P-450b von Wood, A W, Swinney, D C, Thomas, P E, Ryan, D E, Hall, P F, Levin, W, Garland, W A

Volltext

Selective inhibition of mammalian lanosterol 14α-demethylase by RS-21607 in vitro and in vivo von SWINNEY, D. C, ON-YEE SO, WATSON, D. M, BERRY, P. W, WEBB, A. S, KERTESZ, D. J, SHELTON, E. J, BURTON, P. M, WALKER, K. A. M

Volltext

The Kinetic Factors That Determine the Affinity and Selectivity for Slow Binding Inhibition of Human Prostaglandin H Synthase 1 and 2 by Indomethacin and Flurbiprofen (∗) von Callan, Ondine Harris, So, On-Yee, Swinney, David C.

Volltext

Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry von Swinney, D C, Mak, A Y

Volltext

Selective inhibition of mammalian lanosterol 14α-demethylase : a possible strategy for cholesterol lowering von WALKER, K. A. M, KERTESZ, D. J, MILLS-DUNLAP, B, CHIOU, M. Y, TOKES, L. G, KURZ, L. J, KERN, J. R, CHAN, K. W, AMID SALARI, MENDIZABAL, G. R, ROTSTEIN, D. M, SWINNEY, D. C, BERRY, P. W, ON-YEE SO, WEBB, A. S, WATSON, D. M, MAK, A. Y, BURTON, P. M

Volltext

Accumulation of Intermediates and Isotopically Sensitive Enolization Distinguish between Aromatase (Cytochrome P450 CYP19) from Rat Ovary and Human Placenta von Swinney, D.C., Watson, D.M., So, O.Y.

Volltext

Evidence for concerted kinetic oxidation of progesterone by purified rat hepatic cytochrome P-450g von Swinney, David C, Ryan, Dene E, Thomas, Paul E, Levin, Wayne

Volltext

A novel rat hepatic clofibrate-inducible cytochrome P450 that is not a lauric acid hydroxylase von Swinney, David C., Webb, Austin S., Freedman, Richard

Volltext

Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylation von Korzekwa, K R, Swinney, D C, Trager, W F

Volltext

Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases von SCARAFIA, LILIANA E, WINTER, ANDREAS, SWINNEY, DAVID C

Volltext