The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C von D'Arcy, Brandon M, Swingle, Mark R, Papke, Cinta M, Abney, Kevin A, Bouska, Erin S, Prakash, Aishwarya, Honkanen, Richard E

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Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades von Smolen, Kali A., Papke, Cinta M., Swingle, Mark R., Musiyenko, Alla, Li, Chenchen, Salter, E. Alan, Camp, Ashley D., Honkanen, Richard E., Kettenbach, Arminja N.

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A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth von Papke, Cinta M., Smolen, Kali A., Swingle, Mark R., Cressey, Lauren, Heng, Richard A., Toporsian, Mourad, Deng, Liyong, Hagen, Jacob, Shen, Yufeng, Chung, Wendy K., Kettenbach, Arminja N., Honkanen, Richard E.

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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors von Choy, Meng S, Swingle, Mark, D’Arcy, Brandon, Abney, Kevin, Rusin, Scott F, Kettenbach, Arminja N, Page, Rebecca, Honkanen, Richard E, Peti, Wolfgang

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B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations von Wu, Cheng-Guo, Balakrishnan, Vijaya K, Merrill, Ronald A, Parihar, Pankaj S, Konovolov, Kirill, Chen, Yu-Chia, Xu, Zhen, Wei, Hui, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E, Swingle, Mark R, Musiyenko, Alla, Chung, Wendy K, Honkanen, Richard E, Suzuki, Aussie, Huang, Xuhui, Strack, Stefan, Xing, Yongna

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Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation von Salter, E. Alan, Wierzbicki, Andrzej, Honkanen, Richard E., Swingle, Mark R.

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The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer von Golden, Teresa, Swingle, Mark, Honkanen, Richard E.

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Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C von Chattopadhyay, Debasish, Swingle, Mark R., Salter, Edward A., Wood, Eric, D’Arcy, Brandon, Zivanov, Catherine, Abney, Kevin, Musiyenko, Alla, Rusin, Scott F., Kettenbach, Arminja, Yet, Larry, Schroeder, Chad E., Golden, Jennifer E., Dunham, Wade H., Gingras, Anne-Claude, Banerjee, Surajit, Forbes, David, Wierzbicki, Andrzej, Honkanen, Richard E.

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Structural Basis for the Catalytic Activity of Human Serine/Threonine Protein Phosphatase-5 von Swingle, Mark R., Honkanen, Richard E., Ciszak, Ewa M.

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Development of a Synthetic 3-ketosteroid Δ1-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells von D’Arcy, Brandon M., Swingle, Mark R., Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E.

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Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity von Yang, Xiulan, Liu, Yanping, Yang, Xi-Ming, Hu, Fangdi, Cui, Lin, Swingle, Mark R., Honkanen, Richard E., Soltani, Peyman, Tissier, Renaud, Cohen, Michael V., Downey, James M.

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Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12–β13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight... von Swingle, Mark R, Amable, Lauren, Lawhorn, Brian G, Buck, Suzanne B, Burke, Christopher P, Ratti, Pukar, Fischer, Kimberly L, Boger, Dale L, Honkanen, Richard E

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Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C) von Swingle, Mark R, Honkanen, Richard E

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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth von Shuhaibar, Leia C., Kaci, Nabil, Egbert, Jeremy R., Horville, Thibault, Loisay, Lea, Vigone, Giulia, Uliasz, Tracy F., Dambroise, Emilie, Swingle, Mark R., Honkanen, Richard E., Duplan, Martin Biosse, Jaffe, Laurinda A., Legeai-Mallet, Laurence

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Fundamental Role of the Fostriecin Unsaturated Lactone and Implications for Selective Protein Phosphatase Inhibition von Buck, Suzanne B, Hardouin, Christophe, Ichikawa, Satoshi, Soenen, Danielle R, Gauss, C.-M, Hwang, Inkyu, Swingle, Mark R, Bonness, Kathy M, Honkanen, Richard E, Boger, Dale L

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Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues von Burke, Christopher P, Swingle, Mark R, Honkanen, Richard E, Boger, Dale L

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Experimental impacts of climate warming and ocean carbonation on eelgrass Zostera marina von Zimmerman, Richard C., Hill, Victoria J., Jinuntuya, Malee, Celebi, Billur, Ruble, David, Smith, Miranda, Cedeno, Tiffany, Swingle, W. Mark

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Natal homing in juvenile loggerhead turtles (Caretta caretta) von BOWEN, BRIAN W., BASS, ANNA L., CHOW, SHAIO-MEI, BOSTROM, MEREDITH, BJORNDAL, KAREN A., BOLTEN, ALAN B., OKUYAMA, TOSHINORI, BOLKER, BENJAMIN M., EPPERLY, SHERYAN, LACASELLA, ERIN, SHAVER, DONNA, DODD, MARK, HOPKINS- MURPHY, SALLY R., MUSICK, JOHN A., SWINGLE, MARK, RANKIN-BARANSKY, KAREN, TEAS, WENDY, WITZELL, WAYNE N., DUTTON, PETER H.

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Total Synthesis and Evaluation of Cytostatin, Its C10−C11 Diastereomers, and Additional Key Analogues:  Impact on PP2A Inhibition von Lawhorn, Brian G, Boga, Sobhana B, Wolkenberg, Scott E, Colby, David A, Gauss, Carla-Maria, Swingle, Mark R, Amable, Lauren, Honkanen, Richard E, Boger, Dale L

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Loggerhead turtles killed by vessel and fishery interaction in Virginia, USA, are healthy prior to death von Barco, Susan, Law, Mac, Drummond, Bridgette, Koopman, Heather, Trapani, Christina, Reinheimer, Shannon, Rose, Sarah, Swingle, W. Mark, Williard, Amanda

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