Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicio... von Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean

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Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV a... von BELLON, Steven, PARSONS, Jonathan D, YUNYI WEI, HAYAKAWA, Koto, SWENSON, Lora L, CHARIFSON, Paul S, LIPPKE, Judith A, ALDAPE, Robert, GROSS, Christian H

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Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export von Meng, Wuyi, Swenson, Lora L., Fitzgibbon, Matthew J., Hayakawa, Koto, ter Haar, Ernst, Behrens, Anne E., Fulghum, John R., Lippke, Judith A.

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Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicio... von Charifson, Paul S, Grillot, Anne-Laure, Grossman, Trudy H, Parsons, Jonathan D, Badia, Michael, Bellon, Steve, Deininger, David D, Drumm, Joseph E, Gross, Christian H, LeTiran, Arnaud, Liao, Yusheng, Mani, Nagraj, Nicolau, David P, Perola, Emanuele, Ronkin, Steven, Shannon, Dean, Swenson, Lora L, Tang, Qing, Tessier, Pamela R, Tian, Ski-Kai, Trudeau, Martin, Wang, Tiansheng, Wei, Yunyi, Zhang, Hong, Stamos, Dean

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The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain von Griffith, James, Black, James, Faerman, Carlos, Swenson, Lora, Wynn, Michael, Lu, Fan, Lippke, Judith, Saxena, Kumkum

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The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity von Jacobs, Marc, Hayakawa, Koto, Swenson, Lora, Bellon, Steven, Fleming, Mark, Taslimi, Paul, Doran, John

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases von Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J

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Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002 von Jacobs, Marc D., Black, James, Futer, Olga, Swenson, Lora, Hare, Brian, Fleming, Mark, Saxena, Kumkum

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Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase von Cheetham, Graham M T, Knegtel, Ronald M A, Coll, Joyce T, Renwick, Suzanne B, Swenson, Lora, Weber, Peter, Lippke, Judith A, Austen, Douglas A

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Structure of GSK3β reveals a primed phosphorylation mechanism von ter Haar, Ernst, Coll, Joyce T, Austen, Douglas A, Hsiao, Hsun-Mei, Swenson, Lora, Jain, Jugnu

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A novel variant of the catalytic triad in the Streptomyces scabies esterase von Wei, Yunyi, Schottel, Janet L, Derewenda, Urszula, Swenson, Lora, Patkar, Shamkant, Derewenda, Zygmunt S

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Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 å resolution von Wei, Yunyi, Swenson, Lora, Castro, Clementina, Derewenda, Urszula, Minor, Wladek, Arai, Hiroyuki, Aoki, Junken, Inoue, Keizo, Servin-Gonzalez, Luis, Derewenda, Zygmunt S

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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2 von Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.

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Crystal structure, at 2.6-A resolution, of the Streptomyces lividans xylanase A, a member of the F family of beta-1,4-D-glycanases von Derewenda, U, Swenson, L, Green, R, Wei, Y, Morosoli, R, Shareck, F, Kluepfel, D, Derewenda, Z S

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Phenotypic and Structural Analyses of Hepatitis C Virus NS3 Protease Arg155 Variants von Zhou, Yi, Muöh, Ute, Hanzelka, Brian L., Bartels, Doug J., Wei, Yunyi, Rao, B. Govinda, Brennan, Debra L., Tigges, Ann M., Swenson, Lora, Kwong, Ann D., Lin, Chao

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Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer von Ho, Yew S, Swenson, Lora, Derewenda, Urszula, Serre, Laurence, Wei, Yunyi, Dauter, Zbyszek, Hattori, Mitsuharu, Adachi, Tomoya, Aoki, Junken, Arai, Hiroyuki, Inoue, Keizo, Derewenda, Zygmunt S

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Phenotypic Characterization of Resistant Val36 Variants of Hepatitis C Virus NS3-4A Serine Protease von Zhou, Yi, Bartels, Doug J, Hanzelka, Brian L, Müh, Ute, Wei, Yunyi, Chu, Hui-May, Tigges, Ann M, Brennan, Debra L, Rao, B Govinda, Swenson, Lora, Kwong, Ann D, Lin, Chao

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Crystal structure of calcium-free human sorcin: A member of the penta-EF-hand protein family von Xie, X.

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Phenotypic and Structural Analyses of Hepatitis C Virus NS3 Protease Arg super(155) Variants: Sensitivity To Telaprevir (VX-950) And Interferon alpha von Zhou, Yi, Mueh, Ute, Hanzelka, Brian L, Bartels, Doug J, Wei, Yunyi, Rao, BGovinda, Brennan, Debra L, Tigges, Ann M, Swenson, Lora, Kwong, Ann D, Lin, Chao

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Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha von Zhou, Yi, Müh, Ute, Hanzelka, Brian L, Bartels, Doug J, Wei, Yunyi, Rao, B Govinda, Brennan, Debra L, Tigges, Ann M, Swenson, Lora, Kwong, Ann D, Lin, Chao

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