Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium von Liu, Jingshu, Taylor, Rachel L., Baines, Richard A., Swanton, Lisa, Freeman, Sally, Corneo, Barbara, Patel, Achchhe, Marmorstein, Alan, Knudsen, Travis, Black, Graeme C., Manson, Forbes

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Abstract 1859: Inhibition of proteasome deubiquitinase activity prevents cytoprotective aggresome formation in cancer cells von Hillert, Ellin-Kristina, Brjnic, Slavica, Mazurkiewicz, Magdalena, Larsson, Rolf, Fryknäs, Mårten, Swanton, Lisa, High, Stephen, Linder, Stig, D'Arcy, Padraig B.

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Surface expression and distribution of voltage-gated potassium channels in neurons (Review) von McKeown, Lynn, Swanton, Lisa, Robinson, Philip, Jones, Owen T.

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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal von Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I., Nicol, David, O’Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas B.K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles

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Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal von Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O’Brien, Tim, Lopez, Jose I., Watkins, Thomas B.K., Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J., Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C., Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F., Silva, Bruno, Herrero, Javier, Luscombe, Nick M., Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J., Wilson, Gareth A., Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles

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Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal von Mitchell, Thomas J., Turajlic, Samra, Rowan, Andrew, Nicol, David, Farmery, James H.R., O’Brien, Tim, Martincorena, Inigo, Tarpey, Patrick, Angelopoulos, Nicos, Yates, Lucy R., Butler, Adam P., Raine, Keiran, Stewart, Grant D., Challacombe, Ben, Fernando, Archana, Lopez, Jose I., Hazell, Steve, Chandra, Ashish, Chowdhury, Simon, Rudman, Sarah, Soultati, Aspasia, Stamp, Gordon, Fotiadis, Nicos, Pickering, Lisa, Au, Lewis, Spain, Lavinia, Lynch, Joanna, Stares, Mark, Teague, Jon, Maura, Francesco, Wedge, David C., Horswell, Stuart, Chambers, Tim, Litchfield, Kevin, Xu, Hang, Stewart, Aengus, Elaidi, Reza, Oudard, Stéphane, McGranahan, Nicholas, Csabai, Istvan, Gore, Martin, Futreal, P. Andrew, Larkin, James, Lynch, Andy G., Szallasi, Zoltan, Swanton, Charles, Campbell, Peter J.

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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing von Gerlinger, Marco, Horswell, Stuart, Larkin, James, Rowan, Andrew J, Salm, Max P, Varela, Ignacio, Fisher, Rosalie, McGranahan, Nicholas, Matthews, Nicholas, Santos, Claudio R, Martinez, Pierre, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Spencer-Dene, Bradley, Gulati, Sakshi, Bates, Paul A, Stamp, Gordon, Pickering, Lisa, Gore, Martin, Nicol, David L, Hazell, Steven, Futreal, P Andrew, Stewart, Aengus, Swanton, Charles

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing von Gerlinger, Marco, Rowan, Andrew J, Horswell, Stuart, Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q, Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R, Nohadani, Mahrokh, Eklund, Aron C, Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles

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Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers von Gulati, Sakshi, Martinez, Pierre, Joshi, Tejal, Birkbak, Nicolai Juul, Santos, Claudio R, Rowan, Andrew J, Pickering, Lisa, Gore, Martin, Larkin, James, Szallasi, Zoltan, Bates, Paul A, Swanton, Charles, Gerlinger, Marco

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Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue von Litchfield, Kevin, Spain, Lavinia, Gallegos, Lisa L., Schnidrig, Desiree, Rosenbaum, Heidi, Au, Lewis, Hill, Samantha M., Thomas, Jennifer, Thompson, Lisa, Horswell, Stuart, Jones, Carol, Burgess, Daniel L., Watkins, Thomas B.K., Lim, Emilia, Birkbak, Nicolai J., Nordentoft, Iver, Pickering, Lisa, Jamal-Hanjani, Mariam, Shiu, Kai-Keen, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Papadatos-Pastos, Dionysis, Enfield, Katey, McGranahan, Nicholas, Huebner, Ariana, Parker, Peter, Walczak, Henning, Proctor, Ian, Lok, Chi-wah, Moore, David, Marafioti, Teresa, Mitchison, Miriam, Trevisan, Giorgia, Ellery, Peter, Veeriah, Selvaraju, Razaq, Maryam, Shaw, Heather, Manzano, Lizi, Summan, Simranpreet, Kanu, Nnenna, Asghar, Uzma, Tookman, Adrian, Stirling, Caroline, Edmonds, Kim, Hunter, Nikki, Mangwende, Mary, Pearce, Karla, Yan, Haixi, Fendler, Annika, Byrne, Fiona, Popat, Sanjay, Curtis, Olivia, Toncheva, Antonia, Murra, Aida, Korteweg, Justine, Josephs, Debra, Chandra, Ashish, Spicer, James, Mahadeva, Ula, Green, Anna, Stewart, Ruby, Iredale, Lara-Rose, Mackay, Tina, Deakin, Ben, Enting, Debra, Rudman, Sarah, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Michalarea, Vasiliki, Brenton, James, Caldas, Carlos, Fitzgerald, Rebecca, Jimenez-Linan, Merche, Provenzano, Elena, Cluroe, Alison, Gilbertson, Richard, McDermott, Ultan, Tavare, Simon, Beddowes, Emma, Fraser, Sioban, Krebs, Matt, Dransfield, Jo, Le Quesne, John, Fennell, Dean, Langman, Gerald, Robinson, Andrew, Collard, Martin, Cockcroft, Peter, Ferris, Charlotte, Bancroft, Hollie, Kerr, Amy, Wilson, Rodelaine, Tomlinson, Ian, Loda, Massimo, McKenzie, Mairead, Larkin, James, Turajlic, Samra

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Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 von Au, Lewis, Fendler, Annika, Shepherd, Scott T. C., Rzeniewicz, Karolina, Cerrone, Maddalena, Byrne, Fiona, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Shon, John, Haynes, Winston A., Ward, Barry, Shum, Ben, Gordon, William, Gerard, Camille L., Xie, Wenyi, Joharatnam-Hogan, Nalinie, Young, Kate, Pickering, Lisa, Furness, Andrew J. S., Larkin, James, Harvey, Ruth, Kassiotis, George, Gandhi, Sonia, Swanton, Charles, Fribbens, Charlotte, Wilkinson, Katalin A., Wilkinson, Robert J., Lau, David K., Banerjee, Susana, Starling, Naureen, Chau, Ian, Turajlic, Samra

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Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies von Furness, Andrew J.S., Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Spain, Lavinia, Ben Aissa, Assma, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, Mårtensson, Linda, Harrington, Kevin, Wotherspoon, Andrew, Fernando, Archana, Chandra, Ashish, Rudman, Sarah, Varia, Mary, Polson, Alexander, Stamp, Gordon, Hill, Peter, Olsburgh, Jonathan, Lester, Jason, Attanoos, Richard, Adams, Haydn, Shaw, Jacqui, Le Quesne, John, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Martinson, Luke, Kerr, Keith, Miller, Joy, Naidu, Babu, Langman, Gerald, Bellamy, Mary, Summers, Yvonne, Shah, Rajesh, Rammohan, Kendadai, Booton, Richard, Moss, Stuart, Idries, Faiza, Joseph, Leena, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Chemie, Francesca, Tugwood, Jonathan, Lawrence, David, Panagiotopoulos, Nikolaos, Falzon, Mary, Borg, Elaine, Jamal-Hanjani, Mariam, Juul Birkbak, Nicolai, McGranahan, Nicholas, Goldman, Jacki, Veeriah, Raju, Johnson, Diana, Oukrif, Dahmane, Janes, Sam, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Phillimore, Ben, Nye, Emma, Elgar, Greg, Al-Bakir, Maise, Navani, Neal, Gorman, Pat, MacKenzie, Mairead, Bell, Harriet, Hackshaw, Allan, Smith, Sean, Shaw, Emily, Lim, Eric, Nicholson, Andrew, Rice, Alexandra, Carlo Ronquillo, John, Mensah, Natalie, Finch, Jonathan, Lau, Kelvin, Schmid, Peter, Conibear, John, Danson, Sarah, Bury, Jonathan, Hill, Jennifer, Shackcloth, Michael, Feeney, Sarah, Asante-Siaw, Julius, Blyth, Kevin, Kirk, Alan, Pule, Martin, Turajlic, Samra, Peggs, Karl S.

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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors von Lesko, Marta H., Miranda Rota, Enrique, Dahan, Rony, Georgiou, Andrew, Sledzinska, Anna, Werner Sunderland, Mariana, Nicol, David, Beers, Stephen A., Wotherspoon, Andrew, Hayes, Andrew, Stares, Mark, Pickering, Lisa, Rudman, Sarah, Veeriah, Selvaraju, Shafi, Seema, Laycock, Joanne, Bosshard-Carter, Leticia, Goh, Gerald, Rosenthal, Rachel, Hynds, Robert E., Birkbak, Nicolai J., McGranahan, Nicholas, Mitter, Richard, Stewart, Aengus, Rowan, Andrew, Turajlic, Samra, Abbosh, Christopher, Goldman, Jacki, Denner, Tamara, Ward, Sophia, Costa, Marta, Lowe, Helen L., Lawrence, David, Kolvekar, Shyam, Falzon, Mary, Simeon, Celia, Hector, Gemma, Novelli, Marco, Forster, Martin, Papadatos-Pastos, Dionysis, Carnell, Dawn, Navani, Neal, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Taylor, Paul, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Moss, Stuart, Idries, Faiza, Joseph, Leena, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Blackhall, Fiona, Rogan, Jane, Tugwood, Jonathan, Rothwell, Dominic G., Pierce, Jackie, Gulati, Sakshi, Kerr, Amy, Webb, Joanne, Moore, David, Monteiro, William, Marshall, Hilary, Nelson, Louise, Amadi, Anita, Remmen, Hardy, Miller, Joy, Morgan, Fiona, Kornaszewska, Malgorzata, Bell, Harriet, Smith, Sean, Johnson, Benjamin, Lim, Eric, Barbosa, Monica Tavares, Bowman, Alex, Ronquillo, John Carlo, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Buderi, Silviu, Finch, Jonathan, Green, Sophie, Nicholson, Andrew G., Lau, Kelvin, Schmid, Peter, Conibear, John, Ezhil, Veni, Ismail, Babikir, Prakash, Vineet, Horey, Tracey, Swanton, Charles, Chester, Kerry A., Ravetch, Jeffrey V., Marafioti, Teresa, Peggs, Karl S., Quezada, Sergio A.

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders von BAXTER, E, SCOTT, L, CAMPBELL, P, EAST, C, FOUROUCLAS, N, SWANTON, S, VASSILIOU, G, BENCH, A, BOYD, E, CURTIN, N

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Ozone induces a proinflammatory response in primary human bronchial epithelial cells through mitogen-activated protein kinase activation without nuclear factor-κB activation von McCullough, Shaun D, Duncan, Kelly E, Swanton, Samantha M, Dailey, Lisa A, Diaz-Sanchez, David, Devlin, Robert B

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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling von Hobor, Sebastijan, Al Bakir, Maise, Hiley, Crispin T., Skrzypski, Marcin, Frankell, Alexander M., Bakker, Bjorn, Watkins, Thomas B. K., Markovets, Aleksandra, Dry, Jonathan R., Brown, Andrew P., van der Aart, Jasper, van den Bos, Hilda, Spierings, Diana, Oukrif, Dahmane, Novelli, Marco, Chakrabarti, Turja, Rabinowitz, Adam H., Ait Hassou, Laila, Litière, Saskia, Kerr, D. Lucas, Tan, Lisa, Kelly, Gavin, Moore, David A., Renshaw, Matthew J., Venkatesan, Subramanian, Hill, William, Huebner, Ariana, Martínez-Ruiz, Carlos, Black, James R. M., Wu, Wei, Angelova, Mihaela, McGranahan, Nicholas, Downward, Julian, Chmielecki, Juliann, Barrett, Carl, Litchfield, Kevin, Chew, Su Kit, Blakely, Collin M., de Bruin, Elza C., Foijer, Floris, Vousden, Karen H., Bivona, Trever G., Hynds, Robert E., Kanu, Nnennaya, Zaccaria, Simone, Grönroos, Eva, Swanton, Charles

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Copy number architectures define treatment-mediated selection of lethal prostate cancer clones von Hasan, A. M. Mahedi, Cremaschi, Paolo, Wetterskog, Daniel, Jayaram, Anuradha, Wong, Stephen Q., Williams, Scott, Pasam, Anupama, Trigos, Anna, Trujillo, Blanca, Grist, Emily, Friedrich, Stefanie, Vainauskas, Osvaldas, Parry, Marina, Ismail, Mazlina, Devlies, Wout, Wingate, Anna, Linch, Mark, Naceur-Lombardelli, Cristina, Swanton, Charles, Jamal-Hanjani, Mariam, Lise, Stefano, Sandhu, Shahneen, Attard, Gerhardt

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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer von Fendler, Annika, Shepherd, Scott T C, Au, Lewis, Wu, Mary, Harvey, Ruth, Schmitt, Andreas M, Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C, Carr, Edward J, Caidan, Simon, Gavrielides, Mike, MacRae, James I, Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O'Flaherty, Molly, Shea, Robyn L, Gardner, Gail, Murray, Darren, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J S, Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L V, Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Larkin, James, Turajlic, Samra

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IVF outcome in women with PCOS, PCO and normal ovarian morphology von Swanton, Alexander, Storey, Lisa, McVeigh, Enda, Child, Tim

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Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer von Pennycuick, Adam, Teixeira, Vitor H., AbdulJabbar, Khalid, Raza, Shan E. Ahmed, Lund, Tom, Akarca, Ayse U., Rosenthal, Rachel, Kalinke, Lukas, Chandrasekharan, Deepak P., Pipinikas, Christodoulos P., Lee-Six, Henry, Hynds, Robert E., Gowers, Kate H. C., Henry, Jake Y., Millar, Fraser R., Hagos, Yeman B., Denais, Celine, Falzon, Mary, Moore, David A., Antoniou, Sophia, Durrenberger, Pascal F., Furness, Andrew J., Carroll, Bernadette, Marceaux, Claire, Asselin-Labat, Marie-Liesse, Larson, William, Betts, Courtney, Coussens, Lisa M., Thakrar, Ricky M., George, Jeremy, Swanton, Charles, Thirlwell, Christina, Campbell, Peter J., Marafioti, Teresa, Yuan, Yinyin, Quezada, Sergio A., McGranahan, Nicholas, Janes, Sam M.

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