Impact of GPCR Structures on Drug Discovery von Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.

Volltext

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels von McCormack, Ken, Santos, Sonia, Chapman, Mark L, Krafte, Douglas S, Marron, Brian E, West, Christopher W, Krambis, Michael J, Antonio, Brett M, Zellmer, Shannon G, Printzenhoff, David, Padilla, Karen M, Lin, Zhixin, Wagoner, P Kay, Swain, Nigel A, Stupple, Paul A, de Groot, Marcel, Butt, Richard P, Castle, Neil A

Volltext

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

Volltext

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation von Gaulier, Steven M., McKay, Reuben, Swain, Nigel A.

Volltext

Recent progress in sodium channel modulators for pain von Bagal, Sharan K., Chapman, Mark L., Marron, Brian E., Prime, Rebecca, Storer, R. Ian, Swain, Nigel A.

Volltext

Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist von Mowbray, Charles E., Bell, Andrew S., Clarke, Nicholas P., Collins, Michelle, Jones, Rhys M., Lane, Charlotte A.L., Liu, Wai L., Newman, Sandra D., Paradowski, Michael, Schenck, Emanuel J., Selby, Mathew D., Swain, Nigel A., Williams, David H.

Volltext

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective von Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

Volltext

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release von Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B

Volltext

A Versatile Stereoselective Synthesis of endo,exo-Furofuranones:  Application to the Enantioselective Synthesis of Furofuran Lignans von SWAIN, Nigel A., BROWN, Richard C. D., BRUTON, Gordon

Volltext

Voltage gated sodium channels as drug discovery targets von Bagal, Sharan K, Marron, Brian E, Owen, Robert M, Storer, R Ian, Swain, Nigel A

Volltext

Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor von Kelly, Brendan, Hollingsworth, Scott A., Blakemore, David C., Owen, Robert M., Storer, R. Ian, Swain, Nigel A., Aydin, Deniz, Torella, Rubben, Warmus, Joseph S., Dror, Ron O.

Volltext

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes von Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.

Volltext

The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker von Pike, Andy, Flanagan, Neil J, Storer, R Ian, Swain, Nigel A, Tseng, Elaine

Volltext

The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker von Pike, Andy, Flanagan, Neil J., Storer, R. Ian, Swain, Nigel A., Tseng, Elaine

Volltext

Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry von Jones, Lyn H., Summerhill, Nicholas W., Swain, Nigel A., Mills, James E.

Volltext

Discovery of a Series of Indazole TRPA1 Antagonists von Pryde, David C, Marron, Brian E, West, Christopher W, Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J, Turner, Jamie, Warmus, Joseph S, Swain, Nigel A, Omoto, Kiyoyuki, Mahoney, John H, Gerlach, Aaron C

Volltext

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays von Jones, Lyn H, Allan, Gill, Barba, Oscar, Burt, Catherine, Corbau, Romuald, Dupont, Thomas, Knöchel, Thorsten, Irving, Steve, Middleton, Donald S, Mowbray, Charles E, Perros, Manos, Ringrose, Heather, Swain, Nigel A, Webster, Robert, Westby, Mike, Phillips, Chris

Volltext

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R Ian, Stupple, Paul A, West, Christopher W

Volltext

Synthesis of novel histamine H4 receptor antagonists von Lane, Charlotte A.L., Hay, Duncan, Mowbray, Charles E., Paradowski, Michael, Selby, Matthew D., Swain, Nigel A., Williams, David H.

Volltext

An Ammonia-Triggered Stereocontrolled Conversion of a γ-Lactone to the Central Tetrahydropyran of Pederin, Psymberin, and Onnamides D-F von Buffham, William J., Swain, Nigel A., Kostiuk, Sarah L., Gonçalves, Théo P., Harrowven, David C.

Volltext