Impact of GPCR Structures on Drug Discovery von Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.

Volltext

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation von Gaulier, Steven M., McKay, Reuben, Swain, Nigel A.

Volltext

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release von Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B

Volltext

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels von McCormack, Ken, Santos, Sonia, Chapman, Mark L, Krafte, Douglas S, Marron, Brian E, West, Christopher W, Krambis, Michael J, Antonio, Brett M, Zellmer, Shannon G, Printzenhoff, David, Padilla, Karen M, Lin, Zhixin, Wagoner, P Kay, Swain, Nigel A, Stupple, Paul A, de Groot, Marcel, Butt, Richard P, Castle, Neil A

Volltext

Recent progress in sodium channel modulators for pain von Bagal, Sharan K., Chapman, Mark L., Marron, Brian E., Prime, Rebecca, Storer, R. Ian, Swain, Nigel A.

Volltext

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

Volltext

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective von Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

Volltext

Voltage gated sodium channels as drug discovery targets von Bagal, Sharan K, Marron, Brian E, Owen, Robert M, Storer, R Ian, Swain, Nigel A

Volltext

Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor von Kelly, Brendan, Hollingsworth, Scott A., Blakemore, David C., Owen, Robert M., Storer, R. Ian, Swain, Nigel A., Aydin, Deniz, Torella, Rubben, Warmus, Joseph S., Dror, Ron O.

Volltext

Post-socialist generation change in Hungarian farming von Swain, Nigel, Hamza, Eszter

Volltext

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes von Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.

Volltext

Climate Change, Pressures, and Adaptation Capacities of Farmers: Empirical Evidence from Hungary von Lennert, József, Kovács, Katalin, Koós, Bálint, Swain, Nigel, Bálint, Csaba, Hamza, Eszter, Király, Gábor, Rácz, Katalin, Váradi, Monika Mária, Kovács, András Donát

Volltext

The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker von Pike, Andy, Flanagan, Neil J., Storer, R. Ian, Swain, Nigel A., Tseng, Elaine

Volltext

The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker von Pike, Andy, Flanagan, Neil J, Storer, R Ian, Swain, Nigel A, Tseng, Elaine

Volltext

Explaining Illiberal Democracy von Swain, Nigel

Volltext

Explaining Illiberal Democracy - Gábor Scheiring, The Retreat of Liberal Democracy: Authoritarian Capitalism and the Accumulative State in Hungary (Cham, Palgrave Macmillan, 2020,... von Swain, Nigel

Volltext

Discovery of a Series of Indazole TRPA1 Antagonists von Pryde, David C, Marron, Brian E, West, Christopher W, Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J, Turner, Jamie, Warmus, Joseph S, Swain, Nigel A, Omoto, Kiyoyuki, Mahoney, John H, Gerlach, Aaron C

Volltext

Eastern European Rurality in a Neo-Liberal, European Union World von Swain, Nigel

Volltext

Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist von Mowbray, Charles E., Bell, Andrew S., Clarke, Nicholas P., Collins, Michelle, Jones, Rhys M., Lane, Charlotte A.L., Liu, Wai L., Newman, Sandra D., Paradowski, Michael, Schenck, Emanuel J., Selby, Mathew D., Swain, Nigel A., Williams, David H.

Volltext

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays von Jones, Lyn H, Allan, Gill, Barba, Oscar, Burt, Catherine, Corbau, Romuald, Dupont, Thomas, Knöchel, Thorsten, Irving, Steve, Middleton, Donald S, Mowbray, Charles E, Perros, Manos, Ringrose, Heather, Swain, Nigel A, Webster, Robert, Westby, Mike, Phillips, Chris

Volltext