NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks von Vidi, Pierre-Alexandre, Liu, Jing, Salles, Daniela, Jayaraman, Swaathi, Dorfman, George, Gray, Matthew, Abad, Patricia, Moghe, Prabhas V, Irudayaraj, Joseph M, Wiesmüller, Lisa, Lelièvre, Sophie A

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CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice von Doucet, Michele, Jayaraman, Swaathi, Swenson, Emily, Tusing, Brittany, Weber, Kristy L, Kominsky, Scott L

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Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer von Jayaraman, Swaathi, Hou, Xiaonan, Kuffel, Mary J, Suman, Vera J, Hoskin, Tanya L, Reinicke, Kathryn E, Monroe, David G, Kalari, Krishna R, Tang, Xiaojia, Zeldenrust, Megan A, Cheng, Jingfei, Bruinsma, Elizabeth S, Buhrow, Sarah A, McGovern, Renee M, Safgren, Stephanie L, Walden, Chad A, Carter, Jodi M, Reid, Joel M, Ingle, James N, Ames, Matthew M, Hawse, John R, Goetz, Matthew P

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Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer von Jayaraman, Swaathi, Wu, Xinyan, Kalari, Krishna R., Tang, Xiaojia, Kuffel, Mary J., Bruinsma, Elizabeth S., Jalali, Shahrzad, Peterson, Kevin L., Correia, Cristina, Kudgus, Rachel A., Kaufmann, Scott H., Renuse, Santosh, Ingle, James N., Reid, Joel M., Ames, Matthew M., Fields, Alan P., Schellenberg, Matthew J., Hawse, John R., Pandey, Akhilesh, Goetz, Matthew P.

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Endoxifen, an Estrogen Receptor Targeted Therapy: From Bench to Bedside von Jayaraman, Swaathi, Reid, Joel M, Hawse, John R, Goetz, Matthew P

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Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-β-induced expression of VEGFA von Jayaraman, Swaathi, Doucet, Michele, Kominsky, Scott L

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CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα von Jayaraman, Swaathi, Doucet, Michele, Lau, Wen Min, Kominsky, Scott L

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Structure study reveals active and inactive conformations of protein kinase C B1 von Cong, Anh T.Q., Witter, Taylor L., Elizabeth, Bruinsma S., Jayaraman, Swaathi, Dugan, Maria, Hawse, John R., Goetz, Matthew P., Schellenberg, Matthew J.

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The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner von Jayaraman, Swaathi, Chittiboyina, Shirisha, Bai, Yunfeng, Abad, Patricia C, Vidi, Pierre-Alexandre, Stauffacher, Cynthia V, Lelièvre, Sophie A

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Abstract LB078: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) inhibits hormone therapy resistant breast cancer cells, in part by Inhibiting CYP3A4 arachidonic acid epoxygenase activity von Guo, Zhijun, Lei, Jianxun, Hong, Kwon Ho, Norris, Beverly, Flory, Craig M., Jayaraman, Swaathi, McDermott, Connor, Ambrose, Elizabeth, Sevrioukova, Irina, Poulos, Tom, Denisov, Ilia, Sliga, Stephen, Schumacher, Robert J., Georg, Gunda I., Hawse, John R., Goetz, Matthew P., Potter, David A.

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Abstract P6-04-06: Protein kinase C beta 1 (PKCβ1), a novel drug target of Z-endoxifen, inhibits growth of estrogen receptor positive (ER+) breast cancer via activation of the NF-k... von Jayaraman, Swaathi, Kuffel, Mary J, Kalari, Krishna R, Thompson, Kevin J, Tang, Xiaojia, Bruinsma, Elizabeth S, Hawse, John R, Goetz, Matthew P

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Abstract PD8-04: Antitumor activity of Z-endoxifen (ENDX) is mediated via PKCβ1-dependent ERα loss and cell cycle arrest in ERα-positive breast cancer von Jayaraman, Swaathi, Kuffel, Mary J, Kalari, Krishna R, Thompson, Kevin J, Tang, Xiaojia, Suman, Vera J, Bruinsma, Elizabeth S, O'Sullivan, Ciara C, Wang, Liewei, Weinshilboum, Richard, Ingle, James N, Hawse, John R, Goetz, Matthew P

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Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations von Zhang, Chi, Winnard, Jr, Paul T, Dasari, Sidarth, Kominsky, Scott L, Doucet, Michele, Jayaraman, Swaathi, Raman, Venu, Barman, Ishan

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Abstract 1623: CITED2 modulates metastatic ability through effects on IKK-alpha in breast cancer cells von Jayaraman, Swaathi, Doucet, Michele, Lau, Wen M., Kominsky, Scott L.

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CITED2 attenuates macrophage recruitment concordant with the downregulation of CCL20 in breast cancer cells von Jayaraman, Swaathi, Doucet, Michele, Kominsky, Scott L

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Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterationsElectronic supplementary information (ESI) available.... von Zhang, Chi, Winnard Jr, Paul T, Dasari, Sidarth, Kominsky, Scott L, Doucet, Michele, Jayaraman, Swaathi, Raman, Venu, Barman, Ishan

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Abstract P2-24-03: Z-Endoxifen Allosterically Inhibits PKCβI and its Paradoxical Membrane Translocation von Bhattacharya, Sayantani Sarkar, Witter, Taylor L., Cong, Anh T., Bruinsma, Elizabeth S., Jayaraman, Swaathi, Goetz, Matthew P., Hawse, John, Schellenberg, Matthew

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Abstract P3-11-04: Endoxifen Downregulates AKT Phosphorylation Through Protein Kinase C Beta 1 in ER+/HER2- Breast Cancer von Jayaraman, Swaathi, Wu, Xinyan, Kalari, Krishna R., Tang, Xiaojia, Kuffel, Mary, Bruinsma, Elizabeth S., Renuse, Santosh, Ingle, James N., Reid, Joel, Schellenberg, Matthew, Hawse, John, Pandey, Akhilesh, Goetz, Matthew P.

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Abstract LB564: (±) 14,15-epoxyeicosatrienoic acid induces hallmark ER and MYC gene expression and associated ER and c-Myc nuclear translocation in ER+/HER2- breast cancer cells von Lei, Jianxun, Guo, Zhijun, Molina-Vega, Julissa, Cervantes, Paloma, Jayaraman, Swaathi, Hawse, John R., Perez, Carlos, Abrahante, Juan, Tang, Xiaojia, Kalari, Krishna, Wang, Jinhua, Falck, John R., Lange, Carol, Goetz, Matthew P., Potter, David

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Abstract LB102: Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral r... von Guo, Zhijun, Lei, Jianxun, Venkatesh, Hrishi, Owen, David, Bass, Adam, Cannon, Christine, McCarra, Joshua, Koniar, Brenda, Flory, Craig, Norris, Beverly, Schumacher, Robert J., Jayaraman, Swaathi, Hawse, John, Antonarakis, Emmanuel S., Petricoin, Emanuel F., Wulfkuhle, Julia, Cardiff, Robert D., Ambrose, Elizabeth A., Georg, Gunda I., Schwertfeger, Kaylee L., Farrar, Michael A., Croix, Brad St, Goetz, Matthew P., Potter, David A.

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