Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents von Santoni, Gianluca, de Sousa, Julien, de la Mora, Eugenio, Dias, José, Jean, Ludovic, Sussman, Joel L, Silman, Israel, Renard, Pierre-Yves, Brown, Richard C. D, Weik, Martin, Baati, Rachid, Nachon, Florian

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Specific protein dynamics near the solvent glass transition assayed by radiation‐induced structural changes von Weik, M., Ravelli, R.B.G., Silman, I., Sussman, J.L., Gros, P., Kroon, J.

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Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration von Zorbaz, Tamara, Braïki, Anissa, Maraković, Nikola, Renou, Julien, de la Mora, Eugenio, Maček Hrvat, Nikolina, Katalinić, Maja, Silman, Israel, Sussman, Joel L., Mercey, Guillaume, Gomez, Catherine, Mougeot, Romain, Pérez, Belén, Baati, Rachid, Nachon, Florian, Weik, Martin, Jean, Ludovic, Kovarik, Zrinka, Renard, Pierre‐Yves

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Structure of acetylcholinesterase complexed with (−)-galanthamine at 2.3 Å resolution von Greenblatt, H.M., Kryger, G., Lewis, T., Silman, I., Sussman, J.L.

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Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers von Ashani, Y., Gupta, R.D., Goldsmith, M., Silman, I., Sussman, J.L., Tawfik, D.S., Leader, H.

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Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog von Premkumar, L, Greenblatt, H.M, Bageshwar, U.K, Savchenko, T, Gokhman, I, Sussman, J.L, Zamir, A

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The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase von Harel, Michal, Quinn, Daniel M, Nair, Haridasan K, Silman, Israel, Sussman, Joel L

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Structural Features That Stabilize Halophilic Malate Dehydrogenase from an Archaebacterium von Dym, O., Mevarech, M., Sussman, J. L.

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Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C von Sussman, J.L., Harel, M., Frolow, F., Varon, L., Toker, L., Futerman, A.H., Silman, I.

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Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase von Gilson, M. K., Straatsma, T. P., McCammon, J. A., Ripoll, D. R., Faerman, C. H., Axelsen, P. H., Silman, I., Sussman, J. L.

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Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs von Sussman, J.L., Harel, M., Silman, I.

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Human acetylcholinesterase II: In vivo expression and tissue distribution via est analyses von Giles, K., Silman, I., Sussman, J.L.

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Human acetylcholinesterase I: In vitro assembly of subunits von Giles, K., Sussman, J.L., Silman, I.

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pitch of chromatin DNA is reflected in its nucleotide sequence von Trifonov, E.N, Sussman, J.L

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The conjuction of a conserved electrostatic motif and a common cholinesterase fold defines a class of adhesion proteins von Botti, S.A., Felder, C., Sussman, J.L., Silman, I.

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An integrated model for the molecular traffic through the active site of cholinesterases von Botti, S.A., Felder, C., Lifson, S., Silman, I., Sussman, J.L.

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Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared ‘annular’ motif with ChEs. Structural implications for a cell-recognition role of... von Botti, S.A., Felder, C., Sussman, J.L., Silman, I.

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Evidence that the anti-Alzheimer drug, ENA-713, inhibits acetylcholinesterase by more than one mechanism von Bar-On, P., Millard, C.B., Enz, A., Sussman, J.L., Silman, I.

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Refined crystal structures of “aged” and “non-aged” organophosphoryl conjugates of γ-chymotrypsin von Harel, M., Su, C.-T., Frolow, F., Ashani, Y., Silman, I., Sussman, J.L.

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Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with Torpedo californica acetylcholinesterase von Bar-On, P., Harel, M., Millard, C.B., Enz, A., Sussman, J.L., Silman, I.

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