Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target von Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria von Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

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Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials von Creek, Darren J, Charman, William N, Chiu, Francis C K, Prankerd, Richard J, Dong, Yuxiang, Vennerstrom, Jonathan L, Charman, Susan A

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Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors von Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N, Kaminsky, Werner, Charman, Susan A, Matthews, David, Rathod, Pradipsinh K, Phillips, Margaret A

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System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion von Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M, Edgington-Mitchell, Laura E, Charman, Susan A, Creek, Darren J

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Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis von Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W, Jones-Brando, Lorraine, Yolken, Robert H, Bordón, Claudia, Charman, Susan A, Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N, Hinrichs, David J, Meunier, Brigitte, Carruthers, Vern B, Riscoe, Michael K

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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) von Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L

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An in vitro toolbox to accelerate anti-malarial drug discovery and development von Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada

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Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage von Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Chatelain, Eric, Kelly, John M.

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Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials von Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis C. K, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Crespo, Benigno, Sanz, Laura M, Wang, Binglin, Wittlin, Sergio, Charman, Susan A, Avery, Vicky M, Cho, Nobuo, Kamaura, Masahiro

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Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers von Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K

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Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans von Trevaskis, Natalie L., Lee, Given, Escott, Alistair, Phang, Kian Liun, Hong, Jiwon, Cao, Enyuan, Katneni, Kasiram, Charman, Susan A., Han, Sifei, Charman, William N., Phillips, Anthony R. J., Windsor, John A., Porter, Christopher J. H.

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Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp von Davis, Rohan A, Buchanan, Malcolm S, Duffy, Sandra, Avery, Vicky M, Charman, Susan A, Charman, William N, White, Karen L, Shackleford, David M, Edstein, Michael D, Andrews, Katherine T, Camp, David, Quinn, Ronald J

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Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials von Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M, Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A, Yeates, Clive, Gilbert, Ian H

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Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis von Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J.

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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential von Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones von Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L, Shackleford, David M, O'Loughlin, Kathleen G, Charman, Susan A, Mirsalis, Jon C, Guy, R Kiplin

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Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparu... von Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K

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On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity von Edgar, Rebecca C S, Malcolm, Tess R, Siddiqui, Ghizal, Giannangelo, Carlo, Counihan, Natalie A, Challis, Matthew, Duffy, Sandra, Chowdhury, Mrittika, Marfurt, Jutta, Dans, Madeline, Wirjanata, Grennady, Noviyanti, Rintis, Daware, Kajal, Suraweera, Chathura D, Price, Ric N, Wittlin, Sergio, Avery, Vicky M, Drinkwater, Nyssa, Charman, Susan A, Creek, Darren J, de Koning-Ward, Tania F, Scammells, Peter J, McGowan, Sheena

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Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides von Russell, Stephanie, Rahmani, Raphaël, Jones, Amy J, Newson, Harriet L, Neilde, Kevin, Cotillo, Ignacio, Rahmani Khajouei, Marzieh, Ferrins, Lori, Qureishi, Sana, Nguyen, Nghi, Martinez-Martinez, Maria S, Weaver, Donald F, Kaiser, Marcel, Riley, Jennifer, Thomas, John, De Rycker, Manu, Read, Kevin D, Flematti, Gavin R, Ryan, Eileen, Tanghe, Scott, Rodriguez, Ana, Charman, Susan A, Kessler, Albane, Avery, Vicky M, Baell, Jonathan B, Piggott, Matthew J

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