Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality von Van Linden, Annemie A, Baturin, Dmitry, Ford, James B, Fosmire, Susan P, Gardner, Lori, Korch, Christopher, Reigan, Philip, Porter, Christopher C

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STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious von MAYCOTTE, Paola, GEARHEART, Christy M, THORBURN, Andrew, BARNARD, Rebecca, ARYAL, Suraj, MULCAHY LEVY, Jean M, FOSMIRE, Susan P, HANSEN, Ryan J, MORGAN, Michael J, PORTER, Christopher C, GUSTAFSON, Daniel L

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A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia von Garcia, Tamara B, Snedeker, Jonathan C, Baturin, Dmitry, Gardner, Lori, Fosmire, Susan P, Zhou, Chengjing, Jordan, Craig T, Venkataraman, Sujatha, Vibhakar, Rajeev, Porter, Christopher C

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Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma von Tamburini, Beth A, Phang, Tzu L, Fosmire, Susan P, Scott, Milcah C, Trapp, Susan C, Duckett, Megan M, Robinson, Sally R, Slansky, Jill E, Sharkey, Leslie C, Cutter, Gary R, Wojcieszyn, John W, Bellgrau, Donald, Gemmill, Robert M, Hunter, Lawrence E, Modiano, Jaime F

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Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine von Garcia, Tamara B., Fosmire, Susan P., Porter, Christopher C.

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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG von Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Sanford, Bridget, Birks, Diane K., Davidson, Nate, Metselaar, Dennis S., Meel, Michaël Hananja, Lemma, Rakeb, Donson, Andrew, Vijmasi, Trinka, Katagi, Hiroaki, Sola, Ismail, Fosmire, Susan, Alimova, Irina, Steiner, Jenna, Gilani, Ahmed, Hulleman, Esther, Serkova, Natalie J., Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel M., Gupta, Nalin, Monje, Michelle, Jabado, Nada, Jones, Kenneth, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha

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MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia von Jones, Courtney L., Gearheart, Christy M., Fosmire, Susan, Delgado-Martin, Cristina, Evensen, Nikki A., Bride, Karen, Waanders, Angela J., Pais, Faye, Wang, Jinhua, Bhatla, Teena, Bitterman, Danielle S., de Rijk, Simone R., Bourgeois, Wallace, Dandekar, Smita, Park, Eugene, Burleson, Tamara M., Madhusoodhan, Pillai Pallavi, Teachey, David T., Raetz, Elizabeth A., Hermiston, Michelle L., Müschen, Markus, Loh, Mignon L., Hunger, Stephen P., Zhang, Jinghui, Garabedian, Michael J., Porter, Christopher C., Carroll, William L.

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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma von Dahl, Nathan A., Danis, Etienne, Balakrishnan, Ilango, Wang, Dong, Pierce, Angela, Walker, Faye M., Gilani, Ahmed, Serkova, Natalie J., Madhavan, Krishna, Fosmire, Susan, Green, Adam L., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev

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IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression von Rabe, Jennifer L, Gardner, Lori, Hunter, Rae, Fonseca, Jairo A, Dougan, Jodi, Gearheart, Christy M, Leibowitz, Michael S, Lee-Miller, Cathy, Baturin, Dmitry, Fosmire, Susan P, Zelasko, Susan E, Jones, Courtney L, Slansky, Jill E, Rupji, Manali, Dwivedi, Bhakti, Henry, Curtis J, Porter, Christopher C

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Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cells von Choudhary, Rashmi, Baturin, Dmitry, Fosmire, Susan, Freed, Brian, Porter, Christopher C

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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance von Lin, Pei-Yin, Fosmire, Susan P, Park, See-Hyoung, Park, Jin-Young, Baksh, Shairaz, Modiano, Jaime F, Weiss, Robert H

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Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium von Fosmire, Susan P, Dickerson, Erin B, Scott, Allyson M, Bianco, Stacie R, Pettengill, Marilyn J, Meylemans, Heather, Padilla, Marcia, Frazer-Abel, Ashley A, Akhtar, Nasim, Getzy, David M, Wojcieszyn, John, Breen, Matthew, Helfand, Stuart C, Modiano, Jaime F

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Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma von Thomas, Rachael, Wang, Huixia J, Tsai, Pei-Chien, Langford, Cordelia F, Fosmire, Susan P, Jubala, Cristan M, Getzy, David M, Cutter, Gary R, Modiano, Jaime F, Breen, Matthew

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Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors von Thomas, Rachael, Scott, Allyson, Langford, Cordelia F, Fosmire, Susan P, Jubala, Cristan M, Lorentzen, Travis D, Hitte, Christophe, Karlsson, Elinor K, Kirkness, Ewen, Ostrander, Elaine A, Galibert, Francis, Lindblad-Toh, Kerstin, Modiano, Jaime F, Breen, Matthew

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Nicotine-mediated signals modulate cell death and survival of T lymphocytes von Oloris, Silvia C.S., Frazer-Abel, Ashley A., Jubala, Cristan M., Fosmire, Susan P., Helm, Karen M., Robinson, Sally R., Korpela, Derek M., Duckett, Megan M., Baksh, Shairaz, Modiano, Jaime F.

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A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy von Wang, Dong, Veo, Bethany, Pierce, Angela, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Donson, Andrew, Alimova, Irina, Sullivan, Kelly D, Joshi, Molishree, Erlander, Mark, Ridinger, Maya, Foreman, Nicholas K, Venkataraman, Sujatha, Vibhakar, Rajeev

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A Regulatory Loop of FBXW7-MYC-PLK1 Controls Tumorigenesis of MYC-Driven Medulloblastoma von Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Danis, Etienne, Donson, Andrew, Venkataraman, Sujatha, Vibhakar, Rajeev

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MBRS-65. FBXW7 ACTS A TUMOR SUPPRESSOR IN MYC-DRIVEN MEDULLOBLASTOMA BY CONTROLLING A FEED-FORWARD REGULATORY LOOP OF PLK1 AND MYC von Wang, Dong, Pierce, Angela, Veo, Bethany, Fosmire, Susan, Madhavan, Krishna, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev

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ATRT-20. CDK7 INHIBITION IN AT/RT von Morin, Andrew, Veo, Bethany, Fosmire, Susan, Crespo, Michele, Zahedi, Shadi, Vibhakar, Rajeev, Levy, Jean M Mulcahy

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DIPG-32. PRECLINICAL TESTING OF THE EFFICACY AND SAFETY OF CRISPR/CAS9 GENE EDITED CAR-T CELL THERAPY FOR DIFFUSE MIDLINE GLIOMA (DMG) von Balakrishnan, Ilango, Leach, Lillie, Pierce, Angela, Lakshmanachetty, Senthilnath, Madhavan, Krishna, Fosmire, Susan, Chatwin, Hannah, Green, Adam, Fry, Terry, Vibhakar, Rajeev, Kohler, Eric M, Venkataraman, Sujatha

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