The Multifaceted Roles of USP7: New Therapeutic Opportunities von Nicholson, Benjamin, Suresh Kumar, K. G.

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Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47 von Weinstock, Joseph, Wu, Jian, Cao, Ping, Kingsbury, William D, McDermott, Jeffrey L, Kodrasov, Matthew P, McKelvey, Devin M, Suresh Kumar, K. G, Goldenberg, Seth J, Mattern, Michael R, Nicholson, Benjamin

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UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity von Malakhova, Oxana A, Kim II, Keun, Luo, Jiann-Kae, Zou, Weiguo, Kumar, KG Suresh, Fuchs, Serge Y, Shuai, Ke, Zhang, Dong-Er

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Oncogenic BRAF regulates β-Trcp expression and NF-κB activity in human melanoma cells von LIU, J, SURESH KUMAR, K. G, YU, D, MOLTON, S. A, MCMAHON, M, HERLYN, M, THOMAS-TIKHONENKO, A, FUCHS, S. Y

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Phosphorylation and Specific Ubiquitin Acceptor Sites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor von Kumar, K G Suresh, Krolewski, John J, Fuchs, Serge Y

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Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy von Eddins, Michael J., Marblestone, Jeffrey G., Suresh Kumar, K. G., Leach, Craig A., Sterner, David E., Mattern, Michael R., Nicholson, Benjamin

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Ligand-independent pathway that controls stability of interferon alpha receptor von Liu, Jianghuai, Plotnikov, Alexander, Banerjee, Anamika, Suresh Kumar, K.G., Ragimbeau, Josiane, Marijanovic, Zrinka, Baker, Darren P., Pellegrini, Sandra, Fuchs, Serge Y.

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Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis von Kumar, K.G. Suresh, Barriere, Hervé, Carbone, Christopher J, Liu, Jianghuai, Swaminathan, Gayathri, Xu, Ping, Li, Ying, Baker, Darren P, Peng, Junmin, Lukacs, Gergely L, Fuchs, Serge Y

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Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2 von Swaminathan, Gayathri, Varghese, Bentley, Thangavel, Chellappagounder, Carbone, Christopher J, Plotnikov, Alexander, Kumar, K G Suresh, Jablonski, Elizabeth M, Clevenger, Charles V, Goffin, Vincent, Deng, Luqin, Frank, Stuart J, Fuchs, Serge Y

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TYK2 activity promotes ligand-induced IFNAR1 proteolysis von Marijanovic, Zrinka, Ragimbeau, Josiane, Kumar, K G Suresh, Fuchs, Serge Y, Pellegrini, Sandra

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USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms von Pozhidaeva, Alexandra, Valles, Gabrielle, Wang, Feng, Wu, Jian, Sterner, David E., Nguyen, Phuong, Weinstock, Joseph, Kumar, K.G. Suresh, Kanyo, Jean, Wright, Dennis, Bezsonova, Irina

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Novel Approach for Characterizing Ubiquitin E3 Ligase Function von Marblestone, Jeffrey G., Suresh Kumar, K.G., Eddins, Michael J., Leach, Craig A., Sterner, David E., Mattern, Michael R., Nicholson, Benjamin

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A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance von Chauhan, Dharminder, Tian, Ze, Nicholson, Benjamin, Kumar, K.G. Suresh, Zhou, Bin, Carrasco, Ruben, McDermott, Jeffrey L., Leach, Craig A., Fulcinniti, Mariaterresa, Kodrasov, Matthew P., Weinstock, Joseph, Kingsbury, William D., Hideshima, Teru, Shah, Parantu K., Minvielle, Stephane, Altun, Mikael, Kessler, Benedikt M., Orlowski, Robert, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.

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The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer von Fuchs, Serge Y, Spiegelman, Vladimir S, Kumar, K G Suresh

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Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor von Liu, Jianghuai, HuangFu, Wei-Chun, Kumar, K G Suresh, Qian, Juan, Casey, James P, Hamanaka, Robert B, Grigoriadou, Christina, Aldabe, Rafael, Diehl, J Alan, Fuchs, Serge Y

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Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells von Kumar, K.G. Suresh, Liu, Jianghuai, Li, Ying, Yu, Duonan, Thomas-Tikhonenko, Andrei, Herlyn, Meenhard, Fuchs, Serge Y.

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Mammalian Casein Kinase 1α and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling von Liu, Jianghuai, Carvalho, Lucas P., Bhattacharya, Sabyasachi, Carbone, Christopher J., Kumar, K. G. Suresh, Leu, N. Adrian, Yau, Peter M., Donald, Robert G. K., Weiss, Mitchell J., Baker, Darren P., McLaughlin, K. John, Scott, Phillip, Fuchs, Serge Y.

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Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif von Kumar, K.G. Suresh, Varghese, Bentley, Banerjee, Anamika, Baker, Darren P., Constantinescu, Stefan N., Pellegrini, Sandra, Fuchs, Serge Y.

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Negative Regulation of Prolactin Receptor Stability and Signaling Mediated by SCFβ-TrCP E3 Ubiquitin Ligase von Li, Ying, Suresh Kumar, K. G., Tang, Weigang, Spiegelman, Vladimir S., Fuchs, Serge Y.

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Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes von Altun, Mikael, Kramer, Holger B., Willems, Lianne I., McDermott, Jeffrey L., Leach, Craig A., Goldenberg, Seth J., Kumar, K.G. Suresh, Konietzny, Rebecca, Fischer, Roman, Kogan, Edward, Mackeen, Mukram M., McGouran, Joanna, Khoronenkova, Svetlana V., Parsons, Jason L., Dianov, Grigory L., Nicholson, Benjamin, Kessler, Benedikt M.

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