Effect of a novel small molecule yk-4-279 on the "undruggable" target EWS-FLI1 von Toretsky, Jeffrey, Gamble, S. Ellen, Monroe, Philip J., Hong, S. Peter, Summer, Stephen J., Uren, Aykut, Hong, Sung-Hyeok

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Use of pharmacokinetic modeling to optimize direct inhibition of the "undruggable" target EWS-FLI1 of Ewing sarcoma von Toretsky, Jeffrey, Hong, S. Peter, Gamble, S. Ellen, Hong, Sung-Hyeok, Kobs, Christina L., Elsass, Karen E., South, Natalie L., Summer, Stephen J., Monroe, Philip J., Uren, Aykut

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Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation von Long, Brit, Carius, Brandon M., Chavez, Summer, Liang, Stephen Y., Brady, William J., Koyfman, Alex, Gottlieb, Michael

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Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients von Nissen, Steven E., Lincoff, A. Michael, Brennan, Danielle, Ray, Kausik K., Mason, Denise, Kastelein, John J.P., Thompson, Paul D., Libby, Peter, Cho, Leslie, Plutzky, Jorge, Bays, Harold E., Moriarty, Patrick M., Menon, Venu, Grobbee, Diederick E., Louie, Michael J., Chen, Chien-Feng, Li, Na, Bloedon, LeAnne, Robinson, Paula, Horner, Maggie, Sasiela, William J., McCluskey, Jackie, Davey, Deborah, Fajardo-Campos, Pedro, Petrovic, Predrag, Fedacko, Jan, Zmuda, Witold, Lukyanov, Yury, Nicholls, Stephen J.

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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis von Eyre, Steve, Bowes, John, Diogo, Dorothée, Lee, Annette, Barton, Anne, Martin, Paul, Zhernakova, Alexandra, Stahl, Eli, Viatte, Sebastien, McAllister, Kate, Amos, Christopher I, Padyukov, Leonid, Toes, Rene E M, Huizinga, Tom W J, Wijmenga, Cisca, Trynka, Gosia, Franke, Lude, Westra, Harm-Jan, Alfredsson, Lars, Hu, Xinli, Sandor, Cynthia, de Bakker, Paul I W, Davila, Sonia, Khor, Chiea Chuen, Heng, Khai Koon, Andrews, Robert, Edkins, Sarah, Hunt, Sarah E, Langford, Cordelia, Symmons, Deborah, Concannon, Pat, Onengut-Gumuscu, Suna, Rich, Stephen S, Deloukas, Panos, Gonzalez-Gay, Miguel A, Rodriguez-Rodriguez, Luis, Ärlsetig, Lisbeth, Martin, Javier, Rantapää-Dahlqvist, Solbritt, Plenge, Robert M, Raychaudhuri, Soumya, Klareskog, Lars, Gregersen, Peter K, Worthington, Jane

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Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial von Seymour, Matthew T, Prof, Thompson, Lindsay C, MSc, Wasan, Harpreet S, Prof, Middleton, Gary, MD, Brewster, Alison E, MD, Shepherd, Stephen F, MD, O'Mahony, M Sinead, MBBS, Maughan, Timothy S, Prof, Parmar, Mahesh, Prof, Langley, Ruth E, PhD

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Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery von Mazer, C. David, Whitlock, Richard P, Fergusson, Dean A, Hall, Judith, Belley-Cote, Emilie, Connolly, Katherine, Khanykin, Boris, Gregory, Alexander J, de Médicis, Étienne, McGuinness, Shay, Royse, Alistair, Carrier, François M, Young, Paul J, Villar, Juan C, Grocott, Hilary P, Seeberger, Manfred D, Fremes, Stephen, Lellouche, François, Syed, Summer, Byrne, Kelly, Bagshaw, Sean M, Hwang, Nian C, Mehta, Chirag, Painter, Thomas W, Royse, Colin, Verma, Subodh, Hare, Gregory M.T, Cohen, Ashley, Thorpe, Kevin E, Jüni, Peter, Shehata, Nadine

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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses von Wang, Beibei, Skelly, Donal, Pan, Daniel, Omo-Dare, Nicola, Koeckerling, David, Jenkin, Daniel, Fernandes da Costa, Cristiano, Malik, Tariq, Baillie, J. Kenneth, Klenerman, Paul, Pollard, Andrew J., Conlon, Christopher, Jeffery, Katie, Stafford, Lizzie, Chand, Meera, Green, Christoper A., Harrison, Ewen M., Wai Ho, Antonia Ying, Palmarini, Massimo, Price, Nicholas, Robertson, David L., Sigfrid, Louise, Sriskandan, Shiranee, Stuart, David, Swann, Olivia V., Tedder, Richard S., Turtle, Lance CW, Zambon, Maria, Pius, Riinu, Knight, Stephen R., Harrison, Janet, Jackson, Clare, Gamble, Carrol, Plotkin, Daniel, Lee, James, Wham, Murray, Shaw, Victoria, McDonald, Sarah E., Armstrong, Jane A., Ashworth, Milton, Barlow, Samantha L., Bullock, Katie, Davis, Christopher, Dunn, Chris, King, Katharine, Kiy, Robyn T., Lant, Suzannah, Latawiec, Diane, Mancini, Maria, Metelmann, Soeren, Penrice-Randal, Rebekah, Pilgrim, Jack, van Tonder, Libby, Murphy, Lee, Morrice, Kirstie, Gilchrist, Tammy, Aldera, Erin L., Barnass, Stella, Bernatoniene, Jolanta, Bothma, Pieter, Brittain-Long, Robin, Caruth, Vikki, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Dushianthan, Ahilanadan, Evans, Cariad, Harvey, Daniel, Hawcutt, Daniel B., Hodgson, Luke, Hormis, Anil, Kerrison, Caroline, Larkin, Susan, Little, Jeff, Meda, Manjula, Moon, James, Mortimore, Katherine, Murphy, Michael, O’Shea, Matthew K., Otahal, Igor, Panchatsharam, Selva, Patel, Brij, Pepperell, Justin, Peters, Mark, Price, David, Reschreiter, Henrik, Ruge, Bobby, Saluja, Taranprit, Sizer, Jeremy, Shankar-Hari, Manu, Snelson, Catherine, Staines, Nikki, Twagira, Mary, Vincent-Smith, Lisa, Visuvanathan, Shico, Welters, Ingeborg, Wolverson, Adam, Yates, Bryan, Fry, Elizabeth E., Ren, Jingshan

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General Method for the Synthesis of Functionalized Tetrabenzo[8]circulenes von Miller, Robert W, Averill, Summer E, Van Wyck, Stephen J, Whalley, Adam C

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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score von Knight, Stephen R, Ho, Antonia, Pius, Riinu, Buchan, Iain, Carson, Gail, Drake, Thomas M, Dunning, Jake, Fairfield, Cameron J, Gamble, Carrol, Green, Christopher A, Gupta, Rishi, Halpin, Sophie, Hardwick, Hayley E, Holden, Karl A, Horby, Peter W, Jackson, Clare, Mclean, Kenneth A, Merson, Laura, Nguyen-Van-Tam, Jonathan S, Norman, Lisa, Noursadeghi, Mahdad, Olliaro, Piero L, Pritchard, Mark G, Russell, Clark D, Shaw, Catherine A, Sheikh, Aziz, Solomon, Tom, Sudlow, Cathie, Swann, Olivia V, Turtle, Lance CW, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G, Docherty, Annemarie B, Harrison, Ewen M

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Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery von Mazer, C. David, Whitlock, Richard P, Fergusson, Dean A, Belley-Cote, Emilie, Connolly, Katherine, Khanykin, Boris, Gregory, Alexander J, de Médicis, Étienne, Carrier, François M, McGuinness, Shay, Young, Paul J, Byrne, Kelly, Villar, Juan C, Royse, Alistair, Grocott, Hilary P, Seeberger, Manfred D, Mehta, Chirag, Lellouche, François, Hare, Gregory M.T, Painter, Thomas W, Fremes, Stephen, Syed, Summer, Bagshaw, Sean M, Hwang, Nian-Chih, Royse, Colin, Hall, Judith, Dai, David, Mistry, Nikhil, Thorpe, Kevin, Verma, Subodh, Jüni, Peter, Shehata, Nadine

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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition von Corey, Lawrence, Gilbert, Peter B, Juraska, Michal, Montefiori, David C, Morris, Lynn, Karuna, Shelly T, Edupuganti, Srilatha, Mgodi, Nyaradzo M, deCamp, Allan C, Rudnicki, Erika, Huang, Yunda, Gonzales, Pedro, Cabello, Robinson, Orrell, Catherine, Lama, Javier R, Laher, Fatima, Lazarus, Erica M, Sanchez, Jorge, Frank, Ian, Hinojosa, Juan, Sobieszczyk, Magdalena E, Marshall, Kyle E, Mukwekwerere, Pamela G, Makhema, Joseph, Baden, Lindsey R, Mullins, James I, Williamson, Carolyn, Hural, John, McElrath, M. Juliana, Bentley, Carter, Takuva, Simbarashe, Gomez Lorenzo, Margarita M, Burns, David N, Espy, Nicole, Randhawa, April K, Kochar, Nidhi, Piwowar-Manning, Estelle, Donnell, Deborah J, Sista, Nirupama, Andrew, Philip, Kublin, James G, Gray, Glenda, Ledgerwood, Julie E, Mascola, John R, Cohen, Myron S

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Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter von Batzios, Spyros, Tal, Galit, DiStasio, Andrew T, Peng, Yanyan, Charalambous, Christiana, Nicolaides, Paola, Kamsteeg, Erik-Jan, Korman, Stanley H, Mandel, Hanna, Steinbach, Peter J, Yi, Ling, Fair, Summer R, Hester, Mark E, Drousiotou, Anthi, Kaler, Stephen G

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Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study von Docherty, Annemarie B, Jackson, Clare, Mclean, Kenneth A, Pritchard, Mark G, Russell, Clark D, Semple, Malcolm G, Semple, Malcolm G, Alex, Beatrice, Cooke, Graham S, Green, Christopher A, Ijaz, Samreen, Lim, Wei Shen, Meynert, Alison M, Paxton, William A, Robertson, David L, de Silva, Thushan, Sigfrid, Louise, Thwaites, Ryan S, Turtle, Lance CW, Drake, Tom M, Knight, Stephen, Plotkin, Daniel, Mullaney, Scott, Halpin, Sophie, Wham, Murray, Clohisey, Sara, Scott-Brown, James, Greenhalf, William, Asiimwe, Innocent G, Clark, Jordan J, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L, Jones, Christopher B, Latawiec, Diane, Lefteri, Daniella, Metelmann, Soeren, Middleton, Joanna, Sales, Debby, Shaw, Victoria E, Shears, Rebecca K, Tanianis-Hughes, Jolanta, Thomas, Jordan, Zhang, J. Eunice, Agranoff, Daniel, Agwuh, Ken, Angus, Brian, Bassford, Christopher, Bernatoniene, Jolanta, Berridge, John, Brealey, David, Burtenshaw, Andrew, Caruth, Vikki, Child, Jenny, Clark, Tom, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Hardy, Elaine, Harvey, Daniel, Hodgson, Luke, Jacobs, Michael, Kendall, Jason, Linnett, Vanessa, MacNaughton, Emily, Masson, Huw, McCullough, Katherine, Mirfenderesky, Mariyam, Morgan, Patrick, Nelson, Mark, Otahal, Igor, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Post, Frank, Price, David, Rae, Nikolas, Reynolds, Tim, Roberts, Mark, Sharma, Anil, Shankar-Hari, Manu, Stambach, Tom, Subudhi, Pradeep, Szakmany, Tamas, Thompson, Chris, Twagira, Mary, Ustianowski, Andrew, Vallotton, Nick, Vincent-Smith, Lisa, Welters, Ingeborg, Whitehouse, Tony, Williams, Martin, Wilson, Lawrence, Winchester, Stephen, Wolverson, Adam, Young, Peter

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Passive Cycle Training Promotes Bone Recovery after Spinal Cord Injury without Altering Resting-State Bone Perfusion von YARROW, JOSHUA F., WNEK, RUSSELL D., CONOVER, CHRISTINE F., REYNOLDS, MICHAEL C., BUCKLEY, KINLEY H., KURA, JAYACHANDRA R., SUTOR, TOMMY W., OTZEL, DANA M., MATTINGLY, ALEX J., BORST, STEPHEN E., CROFT, SUMMER M., AGUIRRE, J. IGNACIO, BECK, DARREN T., MCCULLOUGH, DANIELLE J.

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Dental Senescence in a Long-Lived Primate Links Infant Survival to Rainfall von King, Stephen J., Arrigo-Nelson, Summer J., Sharon T. Pochron, Gina M. Semprebon, Godfrey, Laurie R., Wright, Patricia C., Jernvall, Jukka

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Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome von Lacro, Ronald V, Dietz, Harry C, Sleeper, Lynn A, Yetman, Anji T, Bradley, Timothy J, Colan, Steven D, Pearson, Gail D, Selamet Tierney, E. Seda, Levine, Jami C, Atz, Andrew M, Benson, D. Woodrow, Braverman, Alan C, Chen, Shan, De Backer, Julie, Gelb, Bruce D, Grossfeld, Paul D, Klein, Gloria L, Lai, Wyman W, Liou, Aimee, Loeys, Bart L, Markham, Larry W, Olson, Aaron K, Paridon, Stephen M, Pemberton, Victoria L, Pierpont, Mary Ella, Pyeritz, Reed E, Radojewski, Elizabeth, Roman, Mary J, Sharkey, Angela M, Stylianou, Mario P, Wechsler, Stephanie Burns, Young, Luciana T, Mahony, Lynn

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Single-cell multi-omics analysis of the immune response in COVID-19 von Stephenson, Emily, Reynolds, Gary, Botting, Rachel A., Calero-Nieto, Fernando J., Morgan, Michael D., Tuong, Zewen Kelvin, Bach, Karsten, Sungnak, Waradon, Worlock, Kaylee B., Yoshida, Masahiro, Kumasaka, Natsuhiko, Kania, Katarzyna, Engelbert, Justin, Olabi, Bayanne, Spegarova, Jarmila Stremenova, Wilson, Nicola K., Mende, Nicole, Jardine, Laura, Gardner, Louis C. S., Goh, Issac, Horsfall, Dave, McGrath, Jim, Webb, Simone, Mather, Michael W., Lindeboom, Rik G. H., Dann, Emma, Huang, Ni, Polanski, Krzysztof, Prigmore, Elena, Gothe, Florian, Scott, Jonathan, Payne, Rebecca P., Baker, Kenneth F., Hanrath, Aidan T., Schim van der Loeff, Ina C. D., Barr, Andrew S., Sanchez-Gonzalez, Amada, Bergamaschi, Laura, Mescia, Federica, Barnes, Josephine L., Kilich, Eliz, de Wilton, Angus, Saigal, Anita, Saleh, Aarash, Janes, Sam M., Smith, Claire M., Gopee, Nusayhah, Wilson, Caroline, Coupland, Paul, Coxhead, Jonathan M., Kiselev, Vladimir Yu, van Dongen, Stijn, Bacardit, Jaume, King, Hamish W., Rostron, Anthony J., Simpson, A. John, Hambleton, Sophie, Laurenti, Elisa, Lyons, Paul A., Meyer, Kerstin B., Nikolić, Marko Z., Duncan, Christopher J. A., Smith, Kenneth G. C., Teichmann, Sarah A., Clatworthy, Menna R., Marioni, John C., Göttgens, Berthold, Haniffa, Muzlifah

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SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion von Mlcochova, Petra, Kemp, Steven A., Dhar, Mahesh Shanker, Papa, Guido, Meng, Bo, Ferreira, Isabella A. T. M., Datir, Rawlings, Collier, Dami A., Albecka, Anna, Singh, Sujeet, Pandey, Rajesh, Brown, Jonathan, Zhou, Jie, Goonawardane, Niluka, Mishra, Swapnil, Whittaker, Charles, Mellan, Thomas, Marwal, Robin, Datta, Meena, Sengupta, Shantanu, Ponnusamy, Kalaiarasan, Radhakrishnan, Venkatraman Srinivasan, Abdullahi, Adam, Charles, Oscar, Chattopadhyay, Partha, Devi, Priti, Caputo, Daniela, Peacock, Tom, Wattal, Chand, Goel, Neeraj, Satwik, Ambrish, Vaishya, Raju, Agarwal, Meenakshi, Mavousian, Antranik, Lee, Joo Hyeon, Bassi, Jessica, Silacci-Fegni, Chiara, Saliba, Christian, Pinto, Dora, Irie, Takashi, Yoshida, Isao, Hamilton, William L., Sato, Kei, Bhatt, Samir, Flaxman, Seth, James, Leo C., Corti, Davide, Piccoli, Luca, Barclay, Wendy S., Rakshit, Partha, Agrawal, Anurag, Gupta, Ravindra K.

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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study von Halpin, Sophie, Donohue, Chloe, Ladhani, Shamez, Horby, Peter W, Docherty, Annemarie B, Semple, Malcolm G, Openshaw, Peter J M, Bach, Benjamin, Chand, Meera, Harrison, Ewen M, Hiscox, Julian A, Horby, Peter W, Klenerman, Paul, Law, Andrew, Moore, Shona C, Palmarini, Massimo, Russell, Clark D, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Thomson, Emma C, Oosthuyzen, Wilna, Norman, Lisa, Pius, Riinu, Mclean, Kenneth A, Saviciute, Egle, Leeming, Gary, Hendry, Ross, Greenhalf, William, Ahmed, Katie A, Asiimwe, Innocent G, Brennan, Benjamin, Catterall, Benjamin WA, Clark, Jordan J, Cole, Sarah, Cox, Helen, Elliott, Angela, Foster, Terry, Greenhalf, Willliam, Jones, Trevor R, Murphy, Ellen G, Small, Benjamin, Subramaniam, Krishanthi S, Tanianis, Jolanta, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Agranoff, Daniel, Angus, Brian, Atkinson, Dougal, Barlow, Gavin, Barrett, Nicholas, Bassford, Christopher, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cupitt, Jason, Dark, Paul, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Goldsmith, Arthur, Hardy, Elaine, Havalda, Peter, Holme, Anita, Kendall, Jason, Kerrison, Caroline, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, MacNaughton, Emily, McCullough, Katherine, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Nelson, Mark, Panchatsharam, Selva, Pintus, Stefania, Prout, Rachel, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shanmuga, Prad, Sharma, Anil, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Stambach, Tom, Tridente, Ascanio, Ustianowski, Andrew, Waddy, Sam, Whittaker, Paul, Williams, Martin, Wiselka, Martin, Young, Peter

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