Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF von Mercer, Paul F, Woodcock, Hannah V, Eley, Jessica D, Platé, Manuela, Sulikowski, Michal G, Durrenberger, Pascal F, Franklin, Linda, Nanthakumar, Carmel B, Man, Yim, Genovese, Federica, McAnulty, Robin J, Yang, Shuying, Maher, Toby M, Nicholson, Andrew G, Blanchard, Andy D, Marshall, Richard P, Lukey, Pauline T, Chambers, Rachel C

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Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment von Hewitt, Susannah L, Bailey, Dyane, Zielinski, John, Apte, Ameya, Musenge, Faith, Karp, Russell, Burke, Shannon, Garcon, Fabien, Mishra, Ankita, Gurumurthy, Sushma, Watkins, Amanda, Arnold, Kristen, Moynihan, James, Clancy-Thompson, Eleanor, Mulgrew, Kathy, Adjei, Grace, Deschler, Katharina, Potz, Darren, Moody, Gordon, Leinster, David A, Novick, Steve, Sulikowski, Michal, Bagnall, Chris, Martin, Philip, Lapointe, Jean-Martin, Si, Han, Morehouse, Chris, Sedic, Maja, Wilkinson, Robert W, Herbst, Ronald, Frederick, Joshua P, Luheshi, Nadia

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Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection von José, Ricardo J, Williams, Andrew E, Mercer, Paul F, Sulikowski, Michal G, Brown, Jeremy S, Chambers, Rachel C

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Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease von Datta, Arnab, Alexander, Robert, Sulikowski, Michal G, Nicholson, Andrew G, Maher, Toby M, Scotton, Chris J, Chambers, Rachel C

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Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model von Luheshi, Nadia M, Coates-Ulrichsen, Jane, Harper, James, Mullins, Stefanie, Sulikowski, Michal G, Martin, Philip, Brown, Lee, Lewis, Arthur, Davies, Gareth, Morrow, Michelle, Wilkinson, Robert W

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Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation von Mercer, Paul F, Williams, Andrew E, Scotton, Christopher J, José, Ricardo J, Sulikowski, Michal, Moffatt, James D, Murray, Lynne A, Chambers, Rachel C

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The analgesic effect of narcotic herbal remedies von Gutowski, Mateusz, Warkocz, Szymon, Sulikowski, Michał, Przerwa, Filip, Byrski, Jakub, Sagan, Karol, Kotrych, Katarzyna, Uzar, Izabela

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Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma von Lau, Doreen, McLean, Mary A, Priest, Andrew N, Gill, Andrew B, Scott, Francis, Patterson, Ilse, Carmo, Bruno, Riemer, Frank, Kaggie, Joshua D, Frary, Amy, Milne, Doreen, Booth, Catherine, Lewis, Arthur, Sulikowski, Michal, Brown, Lee, Lapointe, Jean-Martin, Aloj, Luigi, Graves, Martin J, Brindle, Kevin M, Corrie, Pippa G, Gallagher, Ferdia A

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785 mAZD0171 mediated LIF blockade in combination with chemotherapy and PD-L1 inhibition repolarizes macrophages and increases T cell infiltration via CX3CR1-CX3CL1 axis von Candido, Juliana, Kar, Gozde, Opoku-Ansah, Grace, Hoffmann, Scott, Garcon, Fabien, Gerada, Chelsea, Zhang, Bairu, Sulikowski, Michal, Choudhary, Rakesh, Lapointe, Jean-Martin, Palmer, Douglas C, Jones, Stewart, Wilkinson, Robert, Hammond, Scott, Luheshi, Nadia, Eyles, Jim

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Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia von José, Ricardo, Dr, Williams, Andrew, PhD, Sulikowski, Michal, MSc, Brealey, David, PhD, Brown, Jeremy, Prof, Chambers, Rachel, Prof

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Autoantibodies are associated with disease progression in idiopathic pulmonary fibrosis von Koether, Katerina, Besnard, Valérie, Sandig, Hilary, Carruthers, Alan, Miranda, Elena, Grootenboer-Mignot, Sabine, Taillé, Camille, Chevret, Sylvie, Valeyre, Dominique, Nunes, Hilario, Israel-Biet, Dominique, Lim, Wei Keat, Cottin, Vincent, Corkill, Dominic, Dobson, Claire, Groves, Maria, Ferraro, Franco, Guenzi, Edouard, Huang, Ling, Sulikowski, Michal, Mailleux, Arnaud, Murray, Lynne Anne, Mustelin, Thomas, Strickland, Ian, Sleeman, Matthew A, Crestani, Bruno

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Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes von Boland, Brandon B, Brown, Jr, Charles, Boland, Michelle L, Cann, Jennifer, Sulikowski, Michal, Hansen, Gitte, Grønlund, Rikke V, King, Wanda, Rondinone, Cristina, Trevaskis, James, Rhodes, Christopher J, Grimsby, Joseph S

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MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Shows Differential Brain Activation vs. Liraglutide in Mice von BURKE, LUKE K., BROWN, LEE, LAPOINTE, JEAN-MARTIN, SULIKOWSKI, MICHAL GRZEGORZ, LEWIS, ARTHUR R., TREVASKIS, JAMES, BAKER, DAVID

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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes von Boland, Brandon B, Brown, Charles, Boland, Michelle L, Cann, Jennifer, Sulikowski, Michal, Grimsby, Joseph S, King, Wanda, Rhodes, Christopher J, Trevaskis, James, Rondinone, Cristina, Hansen, Gitte, Grønlund, Rikke V

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1355. The SARS-CoV-2 Monoclonal Antibody AZD3152 Potently Neutralizes Historical and Emerging Variants and is Being Developed for the Prevention and Treatment of COVID-19 in High-r... von Francica, Joseph R, Cai, Yingyun, Diallo, Seme, Rosenthal, Kim, Ren, Kuishu, Flores, Daniel J, Dippel, Andrew, Wu, Yuling, Chen, Xiaoru, Cantu, Erin, Choudhary, Rakesh, Sulikowski, Michal, Adissu, Hibret, Chawla, Bhavna, Kar, Swagata, van Dyk, Nydia, Oganesyan, Vaheh, Rajan, Saravanan, Ryan, Patricia C, Loo, Yueh-Ming, Cohen, Taylor, Esser, Mark T, Blair, Wade

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Abstract 5737: Evaluation of the relationship between target expression and in vivo anti-tumor efficacy of AZD9592, an EGFR/c-MET targeted bispecific antibody drug conjugate von McGrath, Lara, Zheng, Ying, Christ, Simon, Sachs, Christian C., Khelifa, Sihem, Windmüller, Claudia, Sweet, Steve, Kim, Yeoun Jin, Sutton, Daniel, Sulikowski, Michal, Lewis, Arthur, Inigo, Ivan, Floch, Nicolas, Rosfjord, Edward, Arnaldez, Fernanda, Comer, Frank

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Evidence for a functional TSLP signalling axis in fibrotic lung disease von Datta, Arnab, Alexander, Robert, Sulikowski, Michal G., Nicholson, Andrew G, Maher, Toby M, Scotton, Chris J., Chambers, Rachel C.

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Abstract 452: Development and implementation of image analysis-based Quantitative Continuous Score (QCS) for B7-H4 IHC to understand AZD8205 pharmacodynamics von Wortmann, Philipp, Tan, Tze Heng, Haneder, Susanne, Storti, Andrea Ennio, Kapil, Ansh, Chesebrough, Jon, Sutton, Daniel, Sulikowski, Michal, Lewis, Arthur, Koch, Sofia, Sweet, Steve, Song, Zifeng, Chain, David, Kim, Yeoun Jin, Luheshi, Nadia, Kinneer, Krista, Cooper, Zachary A., Rebelatto, Marlon, Schmidt, Günter, Sade, Hadassah, Barrett, J. Carl

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Utilizing Weak-to-Strong Consistency for Semi-Supervised Glomeruli Segmentation von Zhang, Irina, Denholm, Jim, Hamidinekoo, Azam, Ålund, Oskar, Bagnall, Christopher, Huix, Joana Palés, Sulikowski, Michal, Vito, Ortensia, Lewis, Arthur, Unwin, Robert, Soderberg, Magnus, Burlutskiy, Nikolay, Qaiser, Talha

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Utilizing Weak-to-Strong Consistency for Semi-Supervised Glomeruli Segmentation von Zhang, Irina, Denholm, Jim, Hamidinekoo, Azam, Ålund, Oskar, Bagnall, Christopher, Huix, Joana Palés, Sulikowski, Michal, Ortensia Vito, Lewis, Arthur, Unwin, Robert, Soderberg, Magnus, Burlutskiy, Nikolay, Talha Qaiser

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