Discovery of AMG 853, a CRTH2 and DP Dual Antagonist von Liu, Jiwen, Li, An-Rong, Wang, Yingcai, Johnson, Mike G, Su, Yongli, Shen, Wang, Wang, Xuemei, Lively, Sarah, Brown, Matthew, Lai, SuJen, Gonzalez Lopez De Turiso, Felix, Xu, Qingge, Van Lengerich, Bettina, Schmitt, Mike, Fu, Zice, Sun, Ying, Lawlis, Shanna, Seitz, Lisa, Danao, Jay, Wait, Jill, Ye, Qiuping, Tang, Hua Lucy, Grillo, Mark, Collins, Tassie L, Sullivan, Timothy J, Medina, Julio C

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Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction von Chen, Xiaoqi, Kopecky, David J, Mihalic, Jeff, Jeffries, Shawn, Min, Xiaoshan, Heath, Julie, Deignan, Jeff, Lai, SuJen, Fu, Zice, Guimaraes, Cristiano, Shen, Shanling, Li, Shyun, Johnstone, Sheree, Thibault, Stephen, Xu, Haoda, Cardozo, Mario, Shen, Wang, Walker, Nigel, Kayser, Frank, Wang, Zhulun

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Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes von Du, Xiaohui, Kim, Yong-Jae, Lai, SuJen, Chen, Xi, Lizarzaburu, Mike, Turcotte, Simon, Fu, Zice, Liu, Qingxiang, Zhang, Ying, Motani, Alykhan, Oda, Kozo, Okuyama, Ryo, Nara, Futoshi, Murakoshi, Michiko, Fu, Angela, Reagan, Jeff D., Fan, Peter, Xiong, Yumei, Shen, Wang, Li, Leping, Houze, Jonathan, Medina, Julio C.

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Identification of aminopiperidine benzamides as MCHr1 antagonists von Vasudevan, Anil, Verzal, Mary K., Wodka, Derek, Souers, Andrew J., Blackburn, Christopher, Che, Jennifer Lee, Lai, Sujen, Brodjian, Sevan, Falls, Doug H., Dayton, Brian D., Govek, Elizabeth, Daniels, Tom, Geddes, Brad, Marsh, Kennan C., Hernandez, Lisa E., Collins, Christine A., Kym, Philip R.

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Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists von Vasudevan, Anil, LaMarche, Matthew J., Blackburn, Christopher, Che, Jennifer Lee, Luchaco-Cullis, Courtney A., Lai, Sujen, Marsilje, Thomas H., Patane, Michael A., Souers, Andrew J., Wodka, Derek, Geddes, Bradley, Chen, Sumiao, Brodjian, Seven, Falls, Doug H., Dayton, Brian D., Bush, Eugene, Brune, Michael, Shapiro, Robin D., Marsh, Kennan C., Hernandez, Lisa E., Sham, Hing L., Collins, Christine A., Kym, Philip R.

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Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy von Kulkarni, Meghana M, Dwight, Timothy, Marino, Kristen, Allen, Bryce K, Taimi, Mohammed, Bastos, Cecilia, Lai, Sujen, Koh, Cheryl, Samant, Ramya, Tesar, Bethany, Huang, Huang, Chamberlain, Brian, Rice, James M, Tan, Dazhi, Lin, Zhixiong, Shechter, Sharon, Li, Stella, Sparks, Sam, Soutter, Holly, Swann, Steven, Sherman, Woody, Winter, Christopher

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Synthesis of benzimidazoles from 1,1-dibromoethenes von Shen, Wang, Kohn, Todd, Fu, Zice, Jiao, XianYun, Lai, Sujen, Schmitt, Michael

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties von Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 von Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators von Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B

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Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies von Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping

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Corrigendum to “Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes” [Bioorg. Med. Chem. Lett. 22 (2012) 6218–6223] von Du, Xiaohui, Kim, Yong-Jae, Lai, SuJen, Chen, Xi, Lizarzaburu, Mike, Turcotte, Simon, Fu, Zice, Liu, Qingxiang, Zhang, Ying, Motani, Alykhan, Oda, Kozo, Okuyama, Ryo, Nara, Futoshi, Murakoshi, Michiko, Fu, Angela, Reagan, Jeff D., Fan, Peter, Xiong, Yumei, Shen, Wang, Li, Leping, Houze, Jonathan, Medina, Julio C.

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Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists von Blackburn, Christopher, LaMarche, Matthew J., Brown, James, Che, Jennifer Lee, Cullis, Courtney A., Lai, Sujen, Maguire, Martin, Marsilje, Thomas, Geddes, Bradley, Govek, Elizabeth, Kadambi, Vivek, Doherty, Colleen, Dayton, Brian, Brodjian, Sevan, Marsh, Kennan C., Collins, Christine A., Kym, Philip R.

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Tandem Chain Extension−Aldol Reaction:  Syn Selectivity with a Zinc Enolate von Lai, Sujen, Zercher, Charles K, Jasinski, Jerry P, Reid, Seth N, Staples, Richard J

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ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR von RAMSDEN, Philip Dean, DRANSFIELD, Paul John, YEH, Wen-Chen, HOUZE, Jonathan, MA, Zhihua, DEBENEDETTO, Mikkel V, LAI, SuJen, HARVEY, James S, PATTAROPONG, Vatee, CHEN, Yinhong, KHAKOO, Aarif Yusuf, SHARMA, Ankit, SWAMINATH, Gayathri, NISHIMURA, Nobuko

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Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer von Yan, Xuelei, Beck, Hilary Plake, Gustin, Darin J, Low, Jonathan D, McGee, Lawrence R, Olson, Steven H, Fox, Brian M, Zhu, Jiang, Roveto, Philip M, Chen, Xiaoqi, Li, Zhihong, Mihalic, Jeffrey Thomas, Lai, SuJen, Fu, Zice, Gribble, Michael W, McMinn, Dustin L, Deignan, Jeffrey, Gonzalez Lopez De Turiso, Felix, Wang, Xiaodong, Huang, Xin, Medina, Julio C, Rew, Yossup, Eksterowicz, John, Yu, Ming, Kayser, Frank, Kopecky, David John, McIntosh, Joel, Connors, Richard Victor, Gonzalez Buenrostro, Ana, Duquette, I, Jason A, MA, Zhihua, Fu, Jiasheng, Jiao, XianYun, Liu, Jiwen, Li, Yihong, Bartberger, Michael D, Sun, Daqing, Johnson, Michael G, Wang, Yingcai, Fisher, Benjamin, Heath, Julie A, Lucas, Brian S

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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER von WANG, XIAODONG, DUQUETTE, JASON, DEIGNAN, JEFFREY, FISHER, BENJAMIN, MCGEE, LAWRENCE, EKSTEROWICZ, JOHN, MCINTOSH, JOEL, ZHU, JIANG, BECK, HILARY PLAKE, FU, JIASHENG, GUSTIN, DARIN JAMES, LI, ZHIHONG, JOHNSON, MICHAEL, WANG, YINGCHAI, MCMINN, DUSTIN, XIAOQI CHEN, LAI, SUJEN, REW, YOSUP, HUANG, XIN, SUN, DAQING, HEATH, JULIE ANNE, MEDINA, JULIO CESAR, BARTBERGER, MICHAEL DAVID, GONZALEZ LOPEZ DE TURISO, FELIX, LIU, JIWEN, CONNORS, RICHARD VICTOR, KOPECKY, DAVID JOHN, MA, ZHIHUA, FU, ZICE, MIHALIC, JEFFREY THOMAS, YAN, XUELEI, FOX, BRIAN MATTHEW, LOW, JONATHAN DANTE, JIAO, XIANYUN, KAYSER, FRANK, GONZALES BUENROSTRO, ANA, GRIBBLE, JR., MICHAEL WILLIAM, OLSON, STEVEN HOWARD, ROVETO, PHILIP MARLEY, LUCAS, BRIAN STUART, YU, MING, LI, YIHONG

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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER von Gustin Darin James, Sun Daqing, Kayser Frank, Connors Richard Victor, Duquette Jason A, Yu Ming, Deignan Jeffrey, McGee Lawrence R, Huang Xin, Kopecky David John, Liu Jiwen, Wang Yingcai, Fu Jiasheng, Johnson Michael, Ma Zhihua, Roveto Philip Marley, Eksterowicz John, Beck Hilary Place, Fox Brian Matthew, Rew Yosup, Zhu Jiang, Heath Julie Anne, Low Jonathan Dante, Fisher Benjamin, Li Yihong, Chen Xiaoqi, Bartberger Michael David, McMinn Dustin, Jiao Xianjun, Wang Xiaodong, Yan Xuelei, Gonzalez Buenrostro Ana, Gonzalez Lopez de Turiso Felix, McIntosh Joel, Lai Sujen, Mihalic Jeffrey Thomas, Li Zhihong, Gribble Jr. Michael William, Fu Zice, Olson Steven Howard, Lucas Brian Stuart, Medina Julio Cesar

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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER von Gustin, Darin James, Yan, Xuelei, McGee, Lawrence R, McMinn, Dustin, Zhu, Jiang, Chen, Xiaoqi, Heath, Julie Anne, Li, Zhihong, Mihalic, Jeffrey Thomas, Beck, Hilary Place, Jiao, Xianjun, Fu, Zice, Deignan, Jeffrey, Gonzalez Lopez De Turiso, Felix, Ma, Zhihua, Wang, Xiaodong, Huang, Xin, Lai, Sujen, Eksterowicz, John, Roveto, Philip Marley, Yu, Ming, Kayser, Frank, Kopecky, David John, McIntosh, Joel, Connors, Richard Victor, Olson, Steven Howard, Gonzalez Buenrostro, Ana, Fu, Jiasheng, Liu, Jiwen, Low, Jonathan Dante, Li, Yihong, Duquette, Jason A, Fox, Brian Matthew, Bartberger, Michael David, Sun, Daqing, Wang, Yingcai, Medina, Julio Cesar, Gribble, Michael William, Fisher, Benjamin, Johnson, Michael, Lucas, Brian Stuart, Rew, Yosup

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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER von GUSTIN, Darin James, LI, Zhihong, EKSTEROWICZ, John, LAI, Sujen, ZHU, Jiang, LOW, Jonathan Dante, JOHNSON, Michael, OLSON, Steven Howard, YU, Ming, KAYSER, Frank, WANG, Yingcai, HEATH, Julie Anne, FU, Jiasheng, MIHALIC, Jeffrey Thomas, DEIGNAN, Jeffrey, MCINTOSH, Joel, GONZALEZ BUENROSTRO, Ana, DUQUETTE, Jason A, SUN, Daqing, LUCAS, Brian Stuart, WANG, Xiaodong, FU, Zice, MCMINN, Dustin, HUANG, Xin, CONNORS, Richard Victor, MA, Zhihua, GRIBBLE, Jr. Michael William, FOX, Brian Matthew, MCGEE, Lawrence R, ROVETO, Philip Marley, CHEN, Xiaoqi, MEDINA, Julio Cesar, BECK, Hilary Place, LIU, Jiwen, REW, Yosup, LI, Yihong, YAN, Xuelei, KOPECKY, David John, JIAO, Xianjun, BARTBERGER, Michael David, GONZALEZ LOPEZ DE TURISO, Felix, FISHER, Benjamin

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