Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer von Manjarrez-Orduño, Nataly, Menard, Laurence C, Kansal, Selena, Fischer, Paul, Kakrecha, Bijal, Jiang, Can, Cunningham, Mark, Greenawalt, Danielle, Patel, Vishal, Yang, Minghui, Golhar, Ryan, Carman, Julie A, Lezhnin, Sergey, Dai, Hongyue, Kayne, Paul S, Suchard, Suzanne J, Bernstein, Steven H, Nadler, Steven G

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A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety von Suchard, Suzanne J, Davis, Patricia M, Kansal, Selena, Stetsko, Dawn K, Brosius, Ruth, Tamura, James, Schneeweis, Lumelle, Bryson, James, Salcedo, Theodora, Wang, Haiqing, Yang, Zheng, Fleener, Catherine A, Ignatovich, Olga, Plummer, Christopher, Grant, Steven, Nadler, Steven G

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Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression von Liu, Danya, Suchard, Suzanne J, Nadler, Steve G, Ford, Mandy L

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Assessment of Belatacept-Mediated Costimulation Blockade Through Evaluation of CD80/86-Receptor Saturation von LATEK, Robert, FLEENER, Catherine, LAMIAN, Vahideh, KULBOKAS, Edward, DAVIS, Patricia M, SUCHARD, Suzanne J, CURRAN, Mark, VINCENTI, Flavio, TOWNSEND, Robert

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope von Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

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Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699 von Yang, Zheng, Wang, Haiqing, Salcedo, Theodora W, Suchard, Suzanne J, Xie, Jenny H, Schneeweis, Lumelle A, Fleener, Catherine A, Calore, James D, Shi, Rong, Zhang, Sean X Y, Rodrigues, A David, Car, Bruce D, Marathe, Punit H, Nadler, Steven G

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2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses von Liu, Danya, Krummey, Scott M, Badell, I Raul, Wagener, Maylene, Schneeweis, Lumelle A, Stetsko, Dawn K, Suchard, Suzanne J, Nadler, Steven G, Ford, Mandy L

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Potent and Selective Agonists of Sphingosine 1‑Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series von Watterson, Scott H, Guo, Junqing, Spergel, Steve H, Langevine, Charles M, Moquin, Robert V, Shen, Ding Ren, Yarde, Melissa, Cvijic, Mary Ellen, Banas, Dana, Liu, Richard, Suchard, Suzanne J, Gillooly, Kathleen, Taylor, Tracy, Rex-Rabe, Sandra, Shuster, David J, McIntyre, Kim W, Cornelius, Georgia, D’Arienzo, Celia, Marino, Anthony, Balimane, Praveen, Warrack, Bethanne, Salter-Cid, Luisa, McKinnon, Murray, Barrish, Joel C, Carter, Percy H, Pitts, William J, Xie, Jenny, Dyckman, Alaric J

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Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils von Fernandez, Rosemarie, Suchard, Suzanne J

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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction von Davis, Patricia M, Nadler, Steven G, Stetsko, Dawn K, Suchard, Suzanne J

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B cells from African American lupus patients exhibit an activated phenotype von Menard, Laurence C, Habte, Sium, Gonsiorek, Waldemar, Lee, Deborah, Banas, Dana, Holloway, Deborah A, Manjarrez-Orduno, Nataly, Cunningham, Mark, Stetsko, Dawn, Casano, Francesca, Kansal, Selena, Davis, Patricia M, Carman, Julie, Zhang, Clarence K, Abidi, Ferva, Furie, Richard, Nadler, Steven G, Suchard, Suzanne J

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Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1) von Guo, Junqing, Watterson, Scott H., Spergel, Steven H., Kempson, James, Langevine, Charles M., Shen, Ding Ren, Yarde, Melissa, Cvijic, Mary Ellen, Banas, Dana, Liu, Richard, Suchard, Suzanne J., Gillooly, Kathleen, Taylor, Tracy, Rex-Rabe, Sandra, Shuster, David J., McIntyre, Kim W., Cornelius, Georgia, D’Arienzo, Celia, Marino, Anthony, Balimane, Praveen, Salter-Cid, Luisa, McKinnon, Murray, Barrish, Joel C., Carter, Percy H., Pitts, William J., Xie, Jenny, Dyckman, Alaric J.

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An LFA-1 ({alpha}L{beta}2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis von Suchard, Suzanne J, Stetsko, Dawn K, Davis, Patricia M, Skala, Stacey, Potin, Dominique, Launay, Michele, Dhar, T. G. Murali, Barrish, Joel C, Susulic, Vojkan, Shuster, David J, McIntyre, Kim W, McKinnon, Murray, Salter-Cid, Luisa

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-... von Watterson, Scott H, Xiao, Zili, Dodd, Dharmpal S, Tortolani, David R, Vaccaro, Wayne, Potin, Dominique, Launay, Michele, Stetsko, Dawn K, Skala, Stacey, Davis, Patric M, Lee, Deborah, Yang, Xiaoxia, McIntyre, Kim W, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Kadiyala, Pathanjali, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Ziemba, Theresa, Zhang, Huiping, Chen, Bang-Chi, DelMonte, Albert J, Aranibar, Nelly, McKinnon, Murray, Barrish, Joel C, Suchard, Suzanne J, Murali Dhar, T. G

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Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells von Carman, Julie A, Davis, Patricia M, Yang, Wen-Pin, Zhu, Jun, Chang, Han, He, Aiqing, Truong, Amy, Suchard, Suzanne J, Nadler, Steven G

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Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic Acid (BMS-587101... von Potin, Dominique, Launay, Michele, Monatlik, Francoise, Malabre, Patrice, Fabreguettes, Maud, Fouquet, Andre, Maillet, Magali, Nicolai, Eric, Dorgeret, Loïc, Chevallier, François, Besse, Dominique, Dufort, Monique, Caussade, François, Ahmad, Syed Z, Stetsko, Dawn K, Skala, Stacey, Davis, Patricia M, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Postelneck, Jennifer, Townsend, Robert M, Goldfarb, Valentina, Sheriff, Steven, Einspahr, Howard, Kish, Kevin, Malley, Mary F, DiMarco, John D, Gougoutas, Jack Z, Kadiyala, Pathanjali, Cheney, Daniel L, Tejwani, Ravindra W, Murphy, Denette K, Mcintyre, Kim W, Yang, Xiaoxia, Chao, Sam, Leith, Leslie, Xiao, Zili, Mathur, Arvind, Chen, Bang-Chi, Wu, Daugh-Rurng, Traeger, Sarah C, McKinnon, Murray, Barrish, Joel C, Robl, Jeffrey A, Iwanowicz, Edwin J, Suchard, Suzanne J, Dhar, T. G. Murali

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Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45 von Urbanek, Rebecca A, Suchard, Suzanne J, Steelman, Gary B, Knappenberger, Katharine S, Sygowski, Linda A, Veale, Chris A, Chapdelaine, Marc J

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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold von DODD, Dharmpal S, SHERIFF, Steven, MCKINNON, Murray, BARRISH, Joel C, SUCHARD, Suzanne J, MURALI DHAR, T. G, CHANGE, Chiehying J, STETSKO, Dawn K, PHILLIPS, Linda M, YINGRU ZHANG, LAUNAY, Michele, POTIN, Dominique, VACCARO, Wayne, POSS, Michael A

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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold von Potin, Dominique, Launay, Michele, Nicolai, Eric, Fabreguette, Maud, Malabre, Patrice, Caussade, François, Besse, Dominique, Skala, Stacey, Stetsko, Dawn K., Todderud, Gordon, Beno, Brett R., Cheney, Daniel L., Chang, Chiehying J., Sheriff, Steven, Hollenbaugh, Diane L., Barrish, Joel C., Iwanowicz, Edwin J., Suchard, Suzanne J., Dhar, T.G. Murali

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Co-stimulatory molecules as therapeutic targets in allergic airways disease von Suchard, Suzanne J, Trzaskos, James, Nadler, Steven G, McKinnon, Murray J

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