A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact von Queirós, A C, Villamor, N, Clot, G, Martinez-Trillos, A, Kulis, M, Navarro, A, Penas, E M M, Jayne, S, Majid, A, Richter, J, Bergmann, A K, Kolarova, J, Royo, C, Russiñol, N, Castellano, G, Pinyol, M, Bea, S, Salaverria, I, López-Guerra, M, Colomer, D, Aymerich, M, Rozman, M, Delgado, J, Giné, E, González-Díaz, M, Puente, X S, Siebert, R, Dyer, M J S, López-Otín, C, Rozman, C, Campo, E, López-Guillermo, A, Martín-Subero, J I

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Differentiation stage of myeloma plasma cells: biological and clinical significance von Paiva, B, Puig, N, Cedena, M T, de Jong, B G, Ruiz, Y, Rapado, I, Martinez-Lopez, J, Cordon, L, Alignani, D, Delgado, J A, van Zelm, M C, Van Dongen, J J M, Pascual, M, Agirre, X, Prosper, F, Martín-Subero, J I, Vidriales, M-B, Gutierrez, N C, Hernandez, M T, Oriol, A, Echeveste, M A, Gonzalez, Y, Johnson, S K, Epstein, J, Barlogie, B, Morgan, G J, Orfao, A, Blade, J, Mateos, M V, Lahuerta, J J, San-Miguel, J F

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Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus von Javierre, Biola M, Fernandez, Agustin F, Richter, Julia, Al-Shahrour, Fatima, Martin-Subero, J Ignacio, Rodriguez-Ubreva, Javier, Berdasco, Maria, Fraga, Mario F, O'Hanlon, Terrance P, Rider, Lisa G, Jacinto, Filipe V, Lopez-Longo, F Javier, Dopazo, Joaquin, Forn, Marta, Peinado, Miguel A, Carreño, Luis, Sawalha, Amr H, Harley, John B, Siebert, Reiner, Esteller, Manel, Miller, Frederick W, Ballestar, Esteban

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Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia von Vilas-Zornoza, A, Agirre, X, Abizanda, G, Moreno, C, Segura, V, De Martino Rodriguez, A, José-Eneriz, E S, Miranda, E, Martín-Subero, J I, Garate, L, Blanco-Prieto, M J, García de Jalón, J A, Rio, P, Rifón, J, Cigudosa, J C, Martinez-Climent, J A, Román-Gómez, J, Calasanz, M J, Ribera, J M, Prósper, F

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Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes von Ammerpohl, O, Haake, A, Pellissery, S, Giefing, M, Richter, J, Balint, B, Kulis, M, Le, J, Bibikova, M, Drexler, H G, Seifert, M, Shaknovic, R, Korn, B, Küppers, R, Martín-Subero, J I, Siebert, R

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Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV mut and IgHV unmut subgroups von Burns, A, Alsolami, R, Becq, J, Stamatopoulos, B, Timbs, A, Bruce, D, Robbe, P, Vavoulis, D, Clifford, R, Cabes, M, Dreau, H, Taylor, J, Knight, S J L, Mansson, R, Bentley, D, Beekman, R, Martín-Subero, J I, Campo, E, Houlston, R S, Ridout, K E, Schuh, A

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A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation von MARTIN-SUBERO, J. I, IBBOTSON, R, GARDINER, A, GASCOYNE, R. D, GESK, S, HARDER, L, HORSMAN, D. E, KNEBA, M, KÜPPERS, R, MAJID, A, PARRY-JONES, N, RITGEN, M, KLAPPER, W, SALIDO, M, SOLE, F, THIEL, G, WACKER, H.-H, OSCIER, D, WLODARSKA, I, SIEBERT, R, MICHAUX, L, CALLET-BAUCHU, E, BERGER, F, CALASANZ, M. J, DE WOLF-PEETERS, C, DYER, M. J, FELMAN, P

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Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important... von DÜRIG, J, BUG, S, KLEIN-HITPASS, L, BOES, T, JÖNS, T, MARTIN-SUBERO, J. I, HARDER, L, BAUDIS, M, DÜHRSEN, U, SIEBERT, R

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Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transc... von Przybylski, G K, Dik, W A, Wanzeck, J, Grabarczyk, P, Majunke, S, Martin-Subero, J I, Siebert, R, Dölken, G, Ludwig, W-D, Verhaaf, B, van Dongen, J J M, Schmidt, C A, Langerak, A W

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P633: ACTIVE CHROMATIN REGULATORY LANDSCAPE OF STEREOTYPED SUBSETS IN CHRONIC LYMPHOCYTIC LEUKEMIA REVEALS A DISTINCTIVE SIGNATURE IN SUBSET #8 von Tsagiopoulou, M., Chapaprieta, V., Russiñol, N., Pechlivanis, N., Papakonstantinou, N., Stavroyianni, N., Psomopoulos, F., Campo, E., Stamatopoulos, K., Martin‐Subero, J. I.

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Molecular Cytogenetic Analysis of Chromosomal Breakpoints in the IGH, MYC, BCL6, and MALT1 Gene Loci in Primary Cutaneous B-cell Lymphomas von Hallermann, C., Kaune, K.M., Gesk, S., Martin-Subero, J.I., Gunawan, B., Griesinger, F., Vermeer, M.H., Santucci, M., Pimpinelli, N., Willemze, R., Siebert, R., Neumann, C.

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High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma: Lymphoma von Renné, C, Willenbrock, K, Martin-Subero, J I, Hinsch, N, Döring, C, Tiacci, E, Klapper, W, Möller, P, Küppers, R, Hansmann, M-L, Siebert, R, Bräuninger, A

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P1295: DECIPHERING THE ROLE OF MSI2 AS A REGULATOR OF MANTLE CELL LYMPHOMA STEM‐LIKE PROPERTIES von Sureda‐Gómez, M., Balsas, P., Rodríguez, M.‐L., Nadeu, F., De Bolòs, A., Eguileor, Á., Kulis, M., Castellano, G., Giné, E., Demajo, S., Martín‐Subero, J. I., Jares, P., Campo, E., Amador, V.

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P631: A PCR‐BASED ASSAY FOR IGLV3‐21R110 SCREENING CONFIRMS ITS PROGNOSTIC VALUE IN AN INDEPENDENT COHORT OF 613 PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA von Syrykh, C., Russiñol, N., Baumann, T., Kulis, M., Alcoceba, M., González, M., Colado, E., Payer, Á. R., Aymerich, M., Terol, M. J., Ruiz‐Gaspà, S., López‐Guillermo, A., Martín‐Subero, J. I., Colomer, D., Delgado, J., Campo, E., Nadeu, F.

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Partial uniparental disomy: a recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphoma von Nielaender, I, Martín-Subero, J I, Wagner, F, Martínez-Climent, J A, Siebert, R

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Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation von Barrio, S, Gallardo, M, Albizua, E, Jimenez, A, Rapado, I, Ayala, R, Gilsanz, F, Martin-Subero, J I, Martinez-Lopez, J

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Molecular cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci von Gesk, S, Martín-Subero, J I, Harder, L, Luhmann, B, Schlegelberger, B, Calasanz, M J, Grote, W, Siebert, R

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Effect of interface energy on the impact strength of agglomerates von Subero, J, Ning, Z, Ghadiri, M, Thornton, C

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Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization von Hartmann, Sylvia, Martin-Subero, Jose I, Gesk, Stefan, Husken, Julia, Giefing, Maciej, Nagel, Inga, Riemke, Jennifer, Chott, Andreas, Klapper, Wolfram, Parrens, Marie, Merlio, Jean-Philippe, Kuppers, Ralf, Brauninger, Andreas, Siebert, Reiner, Hansmann, Martin-Leo

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Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33) von Nagel, I, Bug, S, Tönnies, H, Ammerpohl, O, Richter, J, Vater, I, Callet-Bauchu, E, Calasanz, M J, Martinez-Climent, J A, Bastard, C, Salido, M, Schroers, E, Martin-Subero, J I, Gesk, S, Harder, L, Majid, A, Dyer, M J S, Siebert, R

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