The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics von Pryde, D C, Swain, NA, Stupple, P A, West, C W, Marron, B, Markworth, C J, Printzenhoff, D, Lin, Z, Cox, P J, Suzuki, R, McMurray, S, Waldron, G J, Payne, CE, Warmus, J S, Chapman, M L

Volltext

The discovery of a potent Na v 1.3 inhibitor with good oral pharmacokinetics von Pryde, D C, Swain, N A, Stupple, P A, West, C W, Marron, B, Markworth, C J, Printzenhoff, D, Lin, Z, Cox, P J, Suzuki, R, McMurray, S, Waldron, G J, Payne, C E, Warmus, J S, Chapman, M L

Volltext

Development of Dirhodium(II)-Catalyzed Generation and Enantioselective 1,3-Dipolar Cycloaddition of Carbonyl Ylides von Hodgson, David M., Stupple, Paul A., Pierard, Françoise Y. T. M., Labande, Agnès H., Johnstone, Craig

Volltext

Catalytic enantioselective rearrangements and cycloadditions involving ylides from diazo compounds von Hodgson, David M., Pierard, Françoise Y. T. M., Stupple, Paul A.

Volltext

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokineticsAll authors are, or were at the time of the work being undertaken, employees of Pfizer von Pryde, D. C, Swain, N. A, Stupple, P. A, West, C. W, Marron, B, Markworth, C. J, Printzenhoff, D, Lin, Z, Cox, P. J, Suzuki, R, McMurray, S, Waldron, G. J, Payne, C. E, Warmus, J. S, Chapman, M. L

Volltext

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics† †All authors are, or were at the time of the work being undertaken, employees of Pfizer von Pryde, D. C., Swain, N. A., Stupple, P. A., West, C. W., Marron, B., Markworth, C. J., Printzenhoff, D., Lin, Z., Cox, P. J., Suzuki, R., McMurray, S., Waldron, G. J., Payne, C. E., Warmus, J. S., Chapman, M. L.

Volltext

Catalytic Enantioselective Tandem Carbonyl Ylide Formation-Cycloaddition von Hodgson, David M., Stupple, Paul A., Johnstone, Craig

Volltext

High Throughput Synthesis of Functionalised 1,3-Diones and Subsequent Heterocycle Formation von Price, David A., Gayton, Simon, Stupple, Paul A.

Volltext

Enantioselective intramolecular 1,3-dipolar cycloadditions of diazocarbonyl-derived oxidopyryliums von Hodgson, David M., Stupple, Paul A., Johnstone, Craig

Volltext

Bicyclo[10.2.1]pentadecenone derivatives by free radical macrocyclisation von Robertson, Jeremy, Burrows, Jeremy N, Stupple, Paul A

Volltext

ChemInform Abstract: Bicyclo[10.2.1]pentadecenone Derivatives by Free Radical Macrocyclization von ROBERTSON, J., BURROWS, J. N., STUPPLE, P. A.

Volltext

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer von Sharma, Shikhar, Chung, Chi-Yeh, Uryu, Sean, Petrovic, Jelena, Cao, Joan, Rickard, Amanda, Nady, Nataliya, Greasley, Samantha, Johnson, Eric, Brodsky, Oleg, Khan, Showkhin, Wang, Hui, Wang, Zhenxiong, Zhang, Yong, Tsaparikos, Konstantinos, Chen, Lei, Mazurek, Anthony, Lapek, John, Kung, Pei-Pei, Sutton, Scott, Richardson, Paul F., Greenwald, Eric C., Yamazaki, Shinji, Jones, Rhys, Maegley, Karen A., Bingham, Patrick, Lam, Hieu, Stupple, Alexandra E., Kamal, Aileen, Chueh, Anderly, Cuzzupe, Anthony, Morrow, Benjamin J., Ren, Bin, Carrasco-Pozo, Catalina, Tan, Chin Wee, Bhuva, Dharmesh D., Allan, Elizabeth, Surgenor, Elliot, Vaillant, François, Pehlivanoglu, Havva, Falk, Hendrik, Whittle, James R., Newman, Janet, Cursons, Joseph, Doherty, Judy P., White, Karen L., MacPherson, Laura, Devlin, Mark, Dennis, Matthew L., Hattarki, Meghan K., De Silva, Melanie, Camerino, Michelle A., Butler, Miriam S., Dolezal, Olan, Pilling, Patricia, Foitzik, Richard, Stupple, Paul A., Lagiakos, H. Rachel, Walker, Scott R., Hediyeh-Zadeh, Soroor, Nuttall, Stewart, Spall, Sukhdeep K., Charman, Susan A., Connor, Theresa, Peat, Thomas S., Avery, Vicky M., Bozikis, Ylva E., Yang, Yuqing, Zhang, Ming, Monahan, Brendon J., Voss, Anne K., Thomas, Tim, Street, Ian P., Dawson, Sarah-Jane, Dawson, Mark A., Lindeman, Geoffrey J., Davis, Melissa J., Visvader, Jane E., Paul, Thomas A.

Volltext

Global evaluation and calibration of a passive air sampler for gaseous mercury von McLagan, David S, Mitchell, Carl P. J, Steffen, Alexandra, Hung, Hayley, Shin, Cecilia, Stupple, Geoff W, Olson, Mark L, Luke, Winston T, Kelley, Paul, Howard, Dean, Edwards, Grant C, Nelson, Peter F, Xiao, Hang, Sheu, Guey-Rong, Dreyer, Annekatrin, Huang, Haiyong, Abdul Hussain, Batual, Lei, Ying D, Tavshunsky, Ilana, Wania, Frank

Volltext

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels von McCormack, Ken, Santos, Sonia, Chapman, Mark L, Krafte, Douglas S, Marron, Brian E, West, Christopher W, Krambis, Michael J, Antonio, Brett M, Zellmer, Shannon G, Printzenhoff, David, Padilla, Karen M, Lin, Zhixin, Wagoner, P Kay, Swain, Nigel A, Stupple, Paul A, de Groot, Marcel, Butt, Richard P, Castle, Neil A

Volltext

Fragment screening for a protein-protein interaction inhibitor to WDR5 von Dennis, Matthew L., Morrow, Benjamin J., Dolezal, Olan, Cuzzupe, Anthony N., Stupple, Alexandra E., Newman, Janet, Bentley, John, Hattarki, Meghan, Nuttall, Stewart D., Foitzik, Richard C., Street, Ian P., Stupple, Paul A., Monahan, Brendon J., Peat, Thomas. S.

Volltext

A field intercomparison of three passive air samplers for gaseous mercury in ambient air von Naccarato, Attilio, Tassone, Antonella, Martino, Maria, Moretti, Sacha, Macagnano, Antonella, Zampetti, Emiliano, Papa, Paolo, Avossa, Joshua, Pirrone, Nicola, Nerentorp, Michelle, Munthe, John, Wängberg, Ingvar, Stupple, Geoff W, Mitchell, Carl P. J, Martin, Adam R, Steffen, Alexandra, Babi, Diana, Prestbo, Eric M, Sprovieri, Francesca, Wania, Frank

Volltext

Isotopic Characterization of Atmospheric Gaseous Elemental Mercury by Passive Air Sampling von Szponar, Natalie, McLagan, David S, Kaplan, Robert J, Mitchell, Carl P. J, Wania, Frank, Steffen, Alexandra, Stupple, Geoff W, Monaci, Fabrizio, Bergquist, Bridget A

Volltext

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release von Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B

Volltext

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation von Kong, Isabella Y., Rimes, Joel S., Light, Amanda, Todorovski, Izabela, Jones, Sarah, Morand, Eric, Knight, Deborah A., Bergman, Ylva E., Hogg, Simon J., Falk, Hendrik, Monahan, Brendon J., Stupple, Paul A., Street, Ian P., Heinzel, Susanne, Bouillet, Philippe, Johnstone, Ricky W., Hodgkin, Philip D., Vervoort, Stephin J., Hawkins, Edwin D.

Volltext

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

Volltext