P4711Contribution of neuronal sodium channel isoform Nav1.8 to enhanced proarrhythmic late sodium current in the human failing heart von Dybkova, N, Ahmad, S, Pabel, S, Hartmann, N, Tirilomis, P, Streckfuss, K, Maier, L, Frey, N, Hasenfuss, G, Sossalla, S

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P5302SCN10A/NaV1.8 channels play a critical role in cellular electrophysiology and arrhythmogenesis of the failing human heart von Dybkova, N., Ahmad, S., Pabel, S., Hartmann, N., Tirilomis, P., Streckfuss, K., Maier, L.S., Frey, N., Hasenfuss, G., Sossalla, S.

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Indoxyl sulfate deteriorates cardiac electrophysiological function and increases the likelihood of arrhythmias in human ventricular myocardial cells von Pfeuffer, O, Koertl, T, Hankowitz, N, Riedl, D, Stengel, L, Maier, L S, Streckfuss-Boemeke, K, Sossalla, S

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Mechanisms of atrial-fibrillation-induced ventricular dysfunction and recovery in the human left ventricular myocardium von Stengel, L, Riedl, D, Koertl, T, Tirilomis, P, Schramm, R, Gummert, J, Maier, L, Streckfuss-Boemecke, K, Pabel, S, Sossalla, S

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The role of the atrium in the development of the Takotsubo Syndrome – investigation of a patient-specific atrial stem cell model von Brandt, C, Huebscher, D, Syed Ali, G, Maurer, W, Hasenfuss, G, Nikolaev, V O, Streckfuss-Boemeke, K

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Electrophysiological remodeling in tachycardia-induced cardiomyopathy von Pabel, S, Knierim, M, Stehle, T, Poeppl, A, Hasenfuss, G, Maier, L, Streckfuss-Boemeke, K, Sossalla, S

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Role of phosphodiesterases in the development of takotsubo syndrome von Huebscher, D, Borchert, T, Hasenfuss, G, Nikolaev, V.O, Streckfuss-Boemeke, K

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The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary von Steffens, Sabine, Schröder, Katrin, Krüger, Martina, Maack, Christoph, Streckfuss-Bömeke, Katrin, Backs, Johannes, Backofen, Rolf, Baeßler, Bettina, Devaux, Yvan, Gilsbach, Ralf, Heijman, Jordi, Knaus, Jochen, Kramann, Rafael, Linz, Dominik, Lister, Allyson L., Maatz, Henrike, Maegdefessel, Lars, Mayr, Manuel, Meder, Benjamin, Nussbeck, Sara Y., Rog-Zielinska, Eva A., Schulz, Marcel H., Sickmann, Albert, Yigit, Gökhan, Kohl, Peter

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RBM20-mutations induce disturbed splicing of calcium relevant genes and guides clinically therapy in different cardiomyopathies von Rebs, S, Sedaghat-Hamedani, F, Kayvanpour, E, Huebscher, D, Wagdi, A, Hasenfuss, G, Meder, B, Streckfuss-Boemeke, K

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3074Analyzing the regulation of a catecholamine-dependent altered cAMP signaling in a patient-specific induced pluripotent stem cell takotsubo-model von Huebscher, D, Borchert, T, Hasenfuss, G, Nikolaev, V, Streckfuss-Boemeke, K

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Cellular mechanisms of early tachycardia-induced ventricular dysfunction in the human heart von Knierim, M, Pabel, S, Paulus, M, Rainer, P, Scherr, D, Hasenfuss, G, Maier, L, Streckfuss-Boemeke, K, Sossalla, S

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RBM20-mutations induce disturbed splicing of calcium relevant genes in patient-specific stem cell models of cardiomyopathies von Rebs, S, Sedaghat-Hamedani, F, Kayvanpour, E, Huebscher, D, Katus, H, Hasenfuss, G, Meder, B, Streckfuss-Boemeke, K

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A large-scale functional high-throughput screening identifies miR-515 and miR-519e as potent inducers of human iPSC-cardiomyocyte proliferation von Renikunta, H V, Lazarow, K, Gong, Y, Shukla, P C, Giral, H, Kratzer, A, Nageswaran, V, Opitz, L, Engel, F B, Haghikia, A, Paneni, F, Von Kries, J P, Streckfuss-Boemeke, K, Landmesser, U, Jakob, P

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Decrease of RNA editing in the failing heart leads to induction of circRNAs von Kokot, K, Kneuer, J, John, D, Rebs, S, Mueller, M, Haas, J, Thiele, H, Mueller, O J, Hille, S, Leuschner, F, Dimmeler, S, Streckfuss-Boemeke, K, Meder, B, Laufs, U, Boeckel, J N

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SCN10A-knock-out improves survival and proarrhythmia in a transgenic heart failure mouse model von Bengel, P.R.F, Krekeler, C, Ahmad, S, Hartmann, N, Tirilomis, P, Maurer, W, Toischer, K, Maier, L.S, Hasenfuss, G, Streckfuss-Boemeke, K, Dybkova, N, Sossalla, S

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Genetic variants in calcium regulatory cardiac genes and their contribution to Takotsubo syndrome von Treu, F, Dybkova, N, Jung, P, Li, Y, Huebscher, D, Maurer, W, Hasenfuss, G, Voigt, N, Sossalla, S, Wollnik, B, Streckfuss-Boemeke, K

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Dysfunctional crosstalk of cardiomyocytes and cardiac fibroblasts in a pluripotent stem cell model of dilated cardiomyopathy von Maurer, W, Koehne, S, Maus, A, Tiburcy, M, Schlick, S, Zibat, A, Zimmermann, W.H, Sossalla, S, Wollnik, B, Streckfuss-Boemeke, K

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Effects of atrial fibrillation on ventricular remodeling in the human heart von Pabel, S, Knierim, M, Stehle, T, Alebrand, F, Paulus, M, Sieme, M, Herwig, M, Sedej, S, Scherr, D, Brochhausen, C, Hasenfuss, G, Maier, L, Hamdani, N, Streckfuss-Boemeke, K, Sossalla, S

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P5697Modulation of CaMKII-dependent proarrhythmias by inhibiting Nav1.8 in failing human and mouse ventricular cardiomyocytes von Ahmad, S, Dybkova, N, Tirilomis, P, Bengel, P, Streckfuss-Boemeke, K, Maier, L S, Hasenfuss, G, Sossalla, S

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P1851Catecholamine-dependent cAMP signaling in a patient-specific induced pluripotent stem cell takotsubo-model von Streckfuss-Boemeke, K, Huebscher, D, Borchert, T, Nikolaev, V O, Sossalla, S T, Templin, C, Hasenfuss, G

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