PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling? von Kenakin, Terry, Strachan, Ryan T.

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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome von Olsen, Reid H. J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.

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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors von Pironti, Gianluigi, Strachan, Ryan T, Abraham, Dennis, Mon-Wei Yu, Samuel, Chen, Minyong, Chen, Wei, Hanada, Kenji, Mao, Lan, Watson, Lewis J, Rockman, Howard A

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation von Staus, Dean P., Strachan, Ryan T., Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W., Kim, Tae Hun, Wingler, Laura M., Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C., Pardon, Els, Steyaert, Jan, Weis, William I., Prosser, R. Scott, Kobilka, Brian K., Costa, Tommaso, Lefkowitz, Robert J.

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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor von Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.

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VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells von English, Justin G., Olsen, Reid H.J., Lansu, Katherine, Patel, Michael, White, Karoline, Cockrell, Adam S., Singh, Darshan, Strachan, Ryan T., Wacker, Daniel, Roth, Bryan L.

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Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library von Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.

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Rapid modulation of spine morphology by the 5-HT₂A serotonin receptor through kalirin-7 signaling von Jones, Kelly A, Srivastava, Deepak P, Allen, John A, Strachan, Ryan T, Roth, Bryan L, Penzes, Peter

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Right ventricular insertion promotes reinitiation of ventricular fibrillation in defibrillation failure von Iijima, Kenichi, Zhang, Hanyu, Strachan, Matthew T., Huang, Jian, Walcott, Gregory P., Rogers, Jack M.

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Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways von Hegde, Akhil, Strachan, Ryan T, Walker, Julia K L

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Screening the receptorome: an efficient approach for drug discovery and target validation von Strachan, Ryan T., Ferrara, Gina, Roth, Bryan L.

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Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors von Foster, Simon R., Hauser, Alexander S., Vedel, Line, Strachan, Ryan T., Huang, Xi-Ping, Gavin, Ariana C., Shah, Sushrut D., Nayak, Ajay P., Haugaard-Kedström, Linda M., Penn, Raymond B., Roth, Bryan L., Bräuner-Osborne, Hans, Gloriam, David E.

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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling von Thomsen, Alex R.B., Plouffe, Bianca, Cahill, Thomas J., Shukla, Arun K., Tarrasch, Jeffrey T., Dosey, Annie M., Kahsai, Alem W., Strachan, Ryan T., Pani, Biswaranjan, Mahoney, Jacob P., Huang, Liyin, Breton, Billy, Heydenreich, Franziska M., Sunahara, Roger K., Skiniotis, Georgios, Bouvier, Michel, Lefkowitz, Robert J.

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Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling von Strachan, Ryan T., Sheffler, Douglas J., Willard, Belinda, Kinter, Michael, Kiselar, Janna G., Roth, Bryan L.

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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin von Nobles, Kelly N, Xiao, Kunhong, Ahn, Seungkirl, Shukla, Arun K, Lam, Christopher M, Rajagopal, Sudarshan, Strachan, Ryan T, Huang, Teng-Yi, Bressler, Erin A, Hara, Makoto R, Shenoy, Sudha K, Gygi, Steven P, Lefkowitz, Robert J

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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor von Kahsai, Alem W, Wisler, James W, Lee, Jungmin, Ahn, Seungkirl, Cahill III, Thomas J, Dennison, S Moses, Staus, Dean P, Thomsen, Alex R B, Anasti, Kara M, Pani, Biswaranjan, Wingler, Laura M, Desai, Hemant, Bompiani, Kristin M, Strachan, Ryan T, Qin, Xiaoxia, Alam, S Munir, Sullenger, Bruce A, Lefkowitz, Robert J

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Allosteric Modulation of β-Arrestin-biased Angiotensin II Type 1 Receptor Signaling by Membrane Stretch von Tang, Wei, Strachan, Ryan T., Lefkowitz, Robert J., Rockman, Howard A.

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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1 von Hara, Makoto R., Kovacs, Jeffrey J., Whalen, Erin J., Rajagopal, Sudarshan, Strachan, Ryan T., Grant, Wayne, Towers, Aaron J., Williams, Barbara, Lam, Christopher M., Xiao, Kunhong, Shenoy, Sudha K., Gregory, Simon G., Ahn, Seungkirl, Duckett, Derek R., Lefkowitz, Robert J.

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Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor von Levit Kaplan, Anat, Strachan, Ryan T, Braz, Joao M, Craik, Veronica, Slocum, Samuel, Mangano, Thomas, Amabo, Vanessa, O'Donnell, Henry, Lak, Parnian, Basbaum, Allan I, Roth, Bryan L, Shoichet, Brian K

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Genotype/phenotype correlations in type 2 neurofibromatosis (NF2): evidence for more severe disease associated with truncating mutations von Evans, D G, Trueman, L, Wallace, A, Collins, S, Strachan, T

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