Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis von Schafer, PH, Parton, A, Gandhi, AK, Capone, L, Adams, M, Wu, L, Bartlett, JB, Loveland, MA, Gilhar, A, Cheung, Y‐F, Baillie, GS, Houslay, MD, Man, H‐W, Muller, GW, Stirling, DI

Volltext

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity von Schafer, P.H., Parton, A., Capone, L., Cedzik, D., Brady, H., Evans, J.F., Man, H.-W., Muller, G.W., Stirling, D.I., Chopra, R.

Volltext

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications von GUPTA, D, TREON, S. P, SCHLOSSMAN, R. L, RICHARDSON, P, RALPH, P, WU, L, PAYVANDI, F, MULLER, G, STIRLING, D. I, ANDERSON, K. C, SHIMA, Y, HIDESHIMA, T, PODAR, K, TAI, Y. T, LIN, B, LENTZSCH, S, DAVIES, F. E, CHAUHAN, D

Volltext

Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy von Hideshima, Teru, Chauhan, Dharminder, Shima, Yoshihito, Raje, Noopur, Davies, Faith E., Tai, Yu-Tzu, Treon, Steven P., Lin, Boris, Schlossman, Robert L., Richardson, Paul, Muller, George, Stirling, David I., Anderson, Kenneth C.

Volltext

Immunomodulatory analogs of thalidomide inhibit growth of Hs sultan cells and angiogenesis in vivo von LENTZSCH, S, LEBLANC, R, POCLAR, K, DAVIES, F, LIN, B, HIDESHIMA, T, CATLEY, L, STIRLING, D. I, ANDERSON, K. C

Volltext

Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced... von BARTLETT, J. B, MICHAE, A, ZELDIS, J, DALGLEISH, A. G, CLARKE, I. A, DREDGE, K, NICHOLSON, S, KRISTELEIT, H, POLYCHRONIS, A, PANDHA, H, MULLER, G. W, STIRLING, Dl

Volltext

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha von Corral, L G, Haslett, P A, Muller, G W, Chen, R, Wong, L M, Ocampo, C J, Patterson, R T, Stirling, D I, Kaplan, G

Volltext

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production von Muller, George W., Chen, Roger, Huang, Shaei-Yun, Corral, Laura G., Wong, Lu Min, Patterson, Rebecca T., Chen, Yuxi, Kaplan, Gilla, Stirling, David I.

Volltext

Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity von Muller, George W, Corral, Laura G, Shire, Mary G, Wang, Hua, Moreira, Andre, Kaplan, Gilla, Stirling, David I

Volltext

Thalidomide analogs and PDE4 inhibition von Muller, George W., Shire, Mary G., Wong, Lu Min, Corral, Laura G., Patterson, Rebecca T., Chen, Yuxi, Stirling, David I.

Volltext

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma von Davies, Faith E., Raje, Noopur, Hideshima, Teru, Lentzsch, Suzanne, Young, Gloria, Tai, Yu-Tzu, Lin, Boris, Podar, Klaus, Gupta, Deepak, Chauhan, Dharminder, Treon, Steven P., Richardson, Paul G., Schlossman, Robert L., Morgan, Gareth J., Muller, George W., Stirling, David I., Anderson, Kenneth C.

Volltext

Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma von Raje, Noopur, Kumar, Shaji, Hideshima, Teru, Ishitsuka, Kenji, Chauhan, Dharminder, Mitsiades, Constantine, Podar, Klaus, Le Gouill, Steven, Richardson, Paul, Munshi, Nikhil C., Stirling, David I., Antin, Joseph H., Anderson, Kenneth C.

Volltext

Thalidomide as a novel therapeutic agent: new uses for an old product von Teo, Steve K., Stirling, David I., Zeldis, Jerome B.

Volltext

Thalidomide Dose Proportionality Assessment following Single Doses to Healthy Subjects von Teo, Steve K., Scheffler, Michael R., Kook, Karin A., Tracewell, William G., Colburn, Wayne A., Stirling, David I., Thomas, Steve D.

Volltext

Safety profile of thalidomide after 53 weeks of oral administration in beagle dogs von TEO, Steve K, EVANS, Mark G, BROCKMAN, Mark J, EHRHART, Julie, MORGAN, J. Michael, STIRLING, David I, THOMAS, Steve D

Volltext

Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity von Dredge, Keith, Marriott, J. Blake, Todryk, Stephen M, Muller, George W, Chen, Roger, Stirling, David I, Dalgleish, Angus G

Volltext

Co-Metabolism [and Discussion] von Dalton, H., Stirling, D. I., Quayle, J. R.

Volltext

Clinical pharmacokinetics of thalidomide von TEO, Steve K, COLBURN, Wayne A, TRACEWELL, William G, KOOK, Karin A, STIRLIN, David I, JAWORSKY, Markian S, SCHEFFLER, Michael A, THOMAS, Steve D, LASKIN, Oscar L

Volltext

Thalidomide in the treatment of leprosy von Teo, Steve K., Resztak, Ken E., Scheffler, Michael A., Kook, Karin A., Zeldis, Jerry B., Stirling, David I., Thomas, Steve D.

Volltext

Methylotrophs : genetics and commercial applications von LIDSTROM, M. E, STIRLING, D. I

Volltext