Adaptive platform trials: definition, design, conduct and reporting considerations von Angus, Derek C, Alexander, Brian M, Berry, Scott, Buxton, Meredith, Lewis, Roger, Paoloni, Melissa, Webb, Steven A. R, Arnold, Steven, Barker, Anna, Berry, Donald A, Bonten, Marc J. M, Brophy, Mary, Butler, Christopher, Cloughesy, Timothy F, Derde, Lennie P. G, Esserman, Laura J, Ferguson, Ryan, Fiore, Louis, Gaffey, Sarah C, Gaziano, J. Michael, Giusti, Kathy, Goossens, Herman, Heritier, Stephane, Hyman, Bradley, Krams, Michael, Larholt, Kay, LaVange, Lisa M, Lavori, Philip, Lo, Andrew W, London, Alex John, Manax, Victoria, McArthur, Colin, O'Neill, Genevieve, Parmigiani, Giovanni, Perlmutter, Jane, Petzold, Elizabeth A, Ritchie, Craig, Rowan, Kathryn M, Seymour, Christopher W, Shapiro, Nathan I, Simeone, Diane M, Smith, Bradley, Spellberg, Bradley, Stern, Ariel Dora, Trippa, Lorenzo, Trusheim, Mark, Viele, Kert, Wen, Patrick Y, Woodcock, Janet

Volltext

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study von Reiman, Eric M., Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T., Huentelman, Matthew J., Beach, Thomas G., Caselli, Richard J., Chen, Yinghua, Su, Yi, Myers, Amanda J., Hardy, John, Paul Vonsattel, Jean, Younkin, Steven G., Bennett, David A., De Jager, Philip L., Larson, Eric B., Crane, Paul K., Keene, C. Dirk, Kamboh, M. Ilyas, Kofler, Julia K., Duque, Linda, Gilbert, John R., Gwirtsman, Harry E., Buxbaum, Joseph D., Dickson, Dennis W., Frosch, Matthew P., Ghetti, Bernardino F., Lunetta, Kathryn L., Wang, Li-San, Hyman, Bradley T., Kukull, Walter A., Foroud, Tatiana, Haines, Jonathan L., Mayeux, Richard P., Pericak-Vance, Margaret A., Schneider, Julie A., Trojanowski, John Q., Farrer, Lindsay A., Schellenberg, Gerard D., Beecham, Gary W., Montine, Thomas J., Jun, Gyungah R.

Volltext

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis von Kunkle, Brian W, Schmidt, Michael, Klein, Hans-Ulrich, Naj, Adam C, Hamilton-Nelson, Kara L, Larson, Eric B, Evans, Denis A, De Jager, Phil L, Crane, Paul K, Buxbaum, Joe D, Ertekin-Taner, Nilufer, Barnes, Lisa L, Fallin, M. Daniele, Manly, Jennifer J, Go, Rodney C. P, Obisesan, Thomas O, Kamboh, M. Ilyas, Bennett, David A, Hall, Kathleen S, Goate, Alison M, Foroud, Tatiana M, Martin, Eden R, Wang, Li-San, Byrd, Goldie S, Farrer, Lindsay A, Haines, Jonathan L, Schellenberg, Gerard D, Mayeux, Richard, Pericak-Vance, Margaret A, Reitz, Christiane, Graff-Radford, Neill R, Martinez, Izri, Ayodele, Temitope, Logue, Mark W, Cantwell, Laura B, Jean-Francois, Melissa, Kuzma, Amanda B, Adams, L.D, Vance, Jeffery M, Cuccaro, Michael L, Chung, Jaeyoon, Mez, Jesse, Lunetta, Kathryn L, Jun, Gyungah R, Lopez, Oscar L, Hendrie, Hugh C, Reiman, Eric M, Kowall, Neil W, Leverenz, James B, Small, Scott A, Levey, Allan I, Golde, Todd E, Saykin, Andrew J, Starks, Takiyah D, Albert, Marilyn S, Hyman, Bradley T, Petersen, Ronald C, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Kaye, Jeffrey A, Henderson, Victor W, DeCarli, Charles, LaFerla, Frank M, Brewer, James B, Miller, Bruce L, Swerdlow, Russell H, Van Eldik, Linda J, Paulson, Henry L, Trojanowski, John Q, Chui, Helena C, Rosenberg, Roger N, Craft, Suzanne, Grabowski, Thomas J, Asthana, Sanjay, Morris, John C, Strittmatter, Stephen M, Kukull, Walter A

Volltext

A novel Alzheimer disease locus located near the gene encoding tau protein von Jun, G, Ibrahim-Verbaas, C A, Vronskaya, M, Chung, J, Naj, A C, Kunkle, B W, Wang, L-S, Bis, J C, Bellenguez, C, Harold, D, Destefano, A L, Grenier-Boley, B, Sims, R, Smith, A V, Chouraki, V, Hamilton-Nelson, K L, Ikram, M A, Fievet, N, Martin, E R, Kamatani, Y, Valladares, O, Laza, A R, Zelenika, D, Choi, S-H, Boland, A, Becker, T, Kukull, W A, van der Lee, S J, Pasquier, F, Cruchaga, C, Beekly, D, Fitzpatrick, A L, Hanon, O, Gill, M, Gudnason, V, Campion, D, Love, S, Bennett, D A, Amin, N, Berr, C, Tsolaki, Magda, Buxbaum, J D, Lopez, O L, Deramecourt, V, Fox, N C, Cantwell, L B, Tárraga, L, Dufouil, C, Hardy, J, Crane, P K, Eiriksdottir, G, Hannequin, D, Clarke, R, Evans, D, Mosley, T H, Letenneur, L, Brayne, C, Maier, W, De Jager, P, Dartigues, J-F, Hampel, H, de Bruijn, R F A G, Tzourio, C, Pastor, P, Larson, E B, O'Donovan, M C, Montine, T J, Nalls, M A, Mead, S, Reiman, E M, Jonsson, P V, St George-Hyslop, P H, Boada, M, Passmore, P, Wendland, J R, Schmidt, R, Morgan, K, Powell, J F, Carasquillo, M, Jakobsdóttir, J, Kauwe, J S K, Rujescu, D, Nöthen, M M, Hofman, A, Jones, L, Haines, J L, Psaty, B M, Van Broeckhoven, C, Holmans, P, Launer, L J, Mayeux, R, Goate, A M, Escott-Price, V, Seshadri, S, Pericak-Vance, M A, Amouyel, P, Williams, J, van Duijn, C M, Schellenberg, G D, Farrer, L A

Volltext

A phase 3 trial of IV immunoglobulin for Alzheimer disease von Relkin, Norman R, Thomas, Ronald G, Rissman, Robert A, Brewer, James B, Rafii, Michael S, van Dyck, Christopher H, Jack, Clifford R, Sano, Mary, Knopman, David S, Raman, Rema, Szabo, Paul, Gelmont, David M, Fritsch, Sandor, Aisen, Paul S

Volltext

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4,and the Risk of Late-Onset Alzheimer Disease in African Americans von Reitz, Christiane, Jun, Gyungah, Naj, Adam, Rajbhandary, Ruchita, Vardarajan, Badri Narayan, Wang, Li-San, Valladares, Otto, Lin, Chiao-Feng, Larson, Eric B, Graff-Radford, Neill R, Evans, Denis, De Jager, Philip L, Crane, Paul K, Buxbaum, Joseph D, Murrell, Jill R, Raj, Towfique, Ertekin-Taner, Nilufer, Logue, Mark, Baldwin, Clinton T, Green, Robert C, Barnes, Lisa L, Cantwell, Laura B, Fallin, M. Daniele, Go, Rodney C. P, Griffith, Patrick, Obisesan, Thomas O, Manly, Jennifer J, Lunetta, Kathryn L, Kamboh, M. Ilyas, Lopez, Oscar L, Bennett, David A, Hendrie, Hugh, Hall, Kathleen S, Goate, Alison M, Byrd, Goldie S, Kukull, Walter A, Foroud, Tatiana M, Haines, Jonathan L, Farrer, Lindsay A, Pericak-Vance, Margaret A, Schellenberg, Gerard D, Mayeux, Richard

Volltext

Alzheimer's disease: analyzing the missing heritability von Ridge, Perry G, Mukherjee, Shubhabrata, Crane, Paul K, Kauwe, John S K

Volltext

Transethnic genome-wide scan identifies novel Alzheimer's disease loci von Jun, Gyungah R, Chung, Jaeyoon, Mez, Jesse, Barber, Robert, Beecham, Gary W, Bennett, David A, Buxbaum, Joseph D, Byrd, Goldie S, Carrasquillo, Minerva M, Crane, Paul K, Cruchaga, Carlos, De Jager, Philip, Ertekin-Taner, Nilufer, Evans, Denis, Fallin, M. Danielle, Foroud, Tatiana M, Friedland, Robert P, Goate, Alison M, Graff-Radford, Neill R, Hendrie, Hugh, Hall, Kathleen S, Hamilton-Nelson, Kara L, Inzelberg, Rivka, Kamboh, M. Ilyas, Kauwe, John S.K, Kukull, Walter A, Kunkle, Brian W, Kuwano, Ryozo, Larson, Eric B, Logue, Mark W, Manly, Jennifer J, Martin, Eden R, Montine, Thomas J, Mukherjee, Shubhabrata, Naj, Adam, Reiman, Eric M, Reitz, Christiane, Sherva, Richard, St. George-Hyslop, Peter H, Thornton, Timothy, Younkin, Steven G, Vardarajan, Badri N, Wang, Li-San, Wendlund, Jens R, Winslow, Ashley R, Haines, Jonathan, Mayeux, Richard, Pericak-Vance, Margaret A, Schellenberg, Gerard, Lunetta, Kathryn L, Farrer, Lindsay A

Volltext

Autoantibodies against the prion protein in individuals with PRNP mutations von Frontzek, Karl, Carta, Manfredi, Losa, Marco, Epskamp, Mirka, Meisl, Georg, Anane, Alice, Brandel, Jean-Philippe, Camenisch, Ulrike, Castilla, Joaquín, Haïk, Stéphane, Knowles, Tuomas, Lindner, Ewald, Lutterotti, Andreas, Minikel, Eric Vallabh, Roiter, Ignazio, Safar, Jiri G., Sanchez-Valle, Raquel, Žáková, Dana, Hornemann, Simone, Aguzzi, Adriano

Volltext

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease von Gonneaud, Julie, Baria, Alex T., Pichet Binette, Alexa, Gordon, Brian A., Chhatwal, Jasmeer P., Cruchaga, Carlos, Jucker, Mathias, Levin, Johannes, Salloway, Stephen, Farlow, Martin, Gauthier, Serge, Benzinger, Tammie L. S., Morris, John C., Bateman, Randall J., Breitner, John C. S., Poirier, Judes, Vachon-Presseau, Etienne, Villeneuve, Sylvia

Volltext

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis von Whitcomb, David C, LaRusch, Jessica, Krasinskas, Alyssa M, Klei, Lambertus, Smith, Jill P, Brand, Randall E, Neoptolemos, John P, Lerch, Markus M, Tector, Matt, Sandhu, Bimaljit S, Guda, Nalini M, Orlichenko, Lidiya, Alkaade, Samer, Amann, Stephen T, Anderson, Michelle A, Baillie, John, Banks, Peter A, Conwell, Darwin, Coté, Gregory A, Cotton, Peter B, DiSario, James, Farrer, Lindsay A, Forsmark, Chris E, Johnstone, Marianne, Gardner, Timothy B, Gelrud, Andres, Greenhalf, William, Haines, Jonathan L, Hartman, Douglas J, Hawes, Robert A, Lawrence, Christopher, Lewis, Michele, Mayerle, Julia, Mayeux, Richard, Melhem, Nadine M, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Pericak-Vance, Margaret A, Romagnuolo, Joseph, Schellenberg, Gerard D, Sherman, Stuart, Simon, Peter, Singh, Vijay P, Slivka, Adam, Stolz, Donna, Sutton, Robert, Weiss, Frank Ulrich, Wilcox, C Mel, Zarnescu, Narcis Octavian, Wisniewski, Stephen R, O'Connell, Michael R, Kienholz, Michelle L, Roeder, Kathryn, Barmada, M Michael, Yadav, Dhiraj, Devlin, Bernie

Volltext

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians von Miyashita, Akinori, Koike, Asako, Jun, Gyungah, Wang, Li-San, Takahashi, Satoshi, Matsubara, Etsuro, Kawarabayashi, Takeshi, Shoji, Mikio, Tomita, Naoki, Arai, Hiroyuki, Asada, Takashi, Harigaya, Yasuo, Ikeda, Masaki, Amari, Masakuni, Hanyu, Haruo, Higuchi, Susumu, Ikeuchi, Takeshi, Nishizawa, Masatoyo, Suga, Masaichi, Kawase, Yasuhiro, Akatsu, Hiroyasu, Kosaka, Kenji, Yamamoto, Takayuki, Imagawa, Masaki, Hamaguchi, Tsuyoshi, Yamada, Masahito, Morihara, Takashi, Moriaha, Takashi, Takeda, Masatoshi, Takao, Takeo, Nakata, Kenji, Fujisawa, Yoshikatsu, Sasaki, Ken, Watanabe, Ken, Nakashima, Kenji, Urakami, Katsuya, Ooya, Terumi, Takahashi, Mitsuo, Yuzuriha, Takefumi, Serikawa, Kayoko, Yoshimoto, Seishi, Nakagawa, Ryuji, Kim, Jong-Won, Ki, Chang-Seok, Won, Hong-Hee, Na, Duk L, Seo, Sang Won, Mook-Jung, Inhee, St George-Hyslop, Peter, Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A, Yoshida, Makiko, Nishida, Nao, Tokunaga, Katsushi, Yamamoto, Ken, Tsuji, Shoji, Kanazawa, Ichiro, Ihara, Yasuo, Schellenberg, Gerard D, Farrer, Lindsay A, Kuwano, Ryozo

Volltext

Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci von Karch, Celeste M, Ezerskiy, Lubov A, Bertelsen, Sarah, Goate, Alison M

Volltext

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy von Müller, Ulrich, Schellenberg, Gerard D, Höglinger, Günter U, Melhem, Nadine M, Dickson, Dennis W, Sleiman, Patrick M A, Wang, Li-San, Klei, Lambertus, Rademakers, Rosa, de Silva, Rohan, Litvan, Irene, Riley, David E, van Swieten, John C, Heutink, Peter, Wszolek, Zbigniew K, Uitti, Ryan J, Vandrovcova, Jana, Hurtig, Howard I, Gross, Rachel G, Maetzler, Walter, Goldwurm, Stefano, Tolosa, Eduardo, Borroni, Barbara, Pastor, Pau, Cantwell, Laura B, Han, Mi Ryung, Dillman, Allissa, van der Brug, Marcel P, Gibbs, J Raphael, Cookson, Mark R, Hernandez, Dena G, Singleton, Andrew B, Farrer, Matthew J, Yu, Chang-En, Golbe, Lawrence I, Revesz, Tamas, Hardy, John, Lees, Andrew J, Devlin, Bernie, Hakonarson, Hakon

Volltext

Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants von Zou, Fanggeng, Chai, High Seng, Younkin, Curtis S, Allen, Mariet, Crook, Julia, Pankratz, V Shane, Carrasquillo, Minerva M, Rowley, Christopher N, Nair, Asha A, Middha, Sumit, Maharjan, Sooraj, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly G, Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin, Kouri, Naomi, Kolbert, Christopher P, Jen, Jin, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer

Volltext

Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients von Racine, Annie M., Tommet, Douglas, D’Aquila, Madeline L., Fong, Tamara G., Gou, Yun, Tabloski, Patricia A., Metzger, Eran D., Hshieh, Tammy T., Schmitt, Eva M., Vasunilashorn, Sarinnapha M., Kunze, Lisa, Vlassakov, Kamen, Abdeen, Ayesha, Lange, Jeffrey, Earp, Brandon, Dickerson, Bradford C., Marcantonio, Edward R., Steingrimsson, Jon, Travison, Thomas G., Inouye, Sharon K., Jones, Richard N.

Volltext

Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study von Vasunilashorn, Sarinnapha M, Ngo, Long H, Dillon, Simon T, Fong, Tamara G, Carlyle, Becky C, Kivisäkk, Pia, Trombetta, Bianca A, Vlassakov, Kamen V, Kunze, Lisa J, Arnold, Steven E, Xie, Zhongcong, Inouye, Sharon K, Libermann, Towia A, Marcantonio, Edward R

Volltext

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration von Franzmeier, Nicolai, Suárez-Calvet, M, Frontzkowski, Lukas, Moore, Annah, Hohman, Timothy J, Morenas-Rodriguez, Estrella, Nuscher, Brigitte, Shaw, Leslie, Trojanowski, John Q, Dichgans, Martin, Kleinberger, Gernot, Haass, Christian, Ewers, Michael

Volltext

Standardization of analysis sets for reporting results from ADNI MRI data von Wyman, Bradley T, Harvey, Danielle J, Crawford, Karen, Bernstein, Matt A, Carmichael, Owen, Cole, Patricia E, Crane, Paul K, DeCarli, Charles, Fox, Nick C, Gunter, Jeffrey L, Hill, Derek, Killiany, Ronald J, Pachai, Chahin, Schwarz, Adam J, Schuff, Norbert, Senjem, Matthew L, Suhy, Joyce, Thompson, Paul M, Weiner, Michael, Jack, Clifford R

Volltext

MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults von DICKERSON, Bradford C, WOLK, David A

Volltext