Biologically active metabolites in drug discovery von Sun, Shaoyi, Wesolowski, Steven S.

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A rapid alternative to X-ray crystallography for chiral determination: Case studies of vibrational circular dichroism (VCD) to advance drug discovery projects von Wesolowski, Steven S., Pivonka, Don E.

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Synthesis of a tetrahydronaphthyridine spiropyrimidinetrione DNA gyrase inhibiting antibacterial agent--differential substitution at all five carbon atoms of pyridine von Basarab, Gregory S, Galullo, Vincent, DeGrace, Nancy, Hauck, Sheila, Joubran, Camil, Wesolowski, Steven S

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Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators von O’Brien, Daniel E., Shaw, Douglas M., Cho, Hyekyung P., Cross, Alan J., Wesolowski, Steven S., Felts, Andrew S., Bergare, Jonas, Elmore, Charles S., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy von Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R

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Electron Affinities of the DNA and RNA Bases von Wesolowski, Steven S, Leininger, Matthew L, Pentchev, Plamen N, Schaefer, Henry F

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Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening von Bürli, Roland W., Wei, Huijun, Ernst, Glen, Mariga, Abigail, Hardern, Ian M., Herlihy, Kara, Cross, Alan J., Wesolowski, Steven S., Chen, Hongming, McKay, Ronald D.G., Weinberger, Daniel R., Brandon, Nicholas J., Barrow, James C.

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na V 1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy von Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, Jr, J P, Dehnhardt, Christoph M, Empfield, James R

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Quantification of the interrelationships of receptor pharmacologies within a tricyclic privileged structural scaffold through application of modified forward selection von Wood, Michael W., Wesolowski, Steven S., Widzowski, Daniel V., Cross, Alan J.

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Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro von Wobst, Heike J, Wesolowski, Steven S, Chadchankar, Jayashree, Delsing, Louise, Jacobsen, Steven, Mukherjee, Jayanta, Deeb, Tarek Z, Dunlop, John, Brandon, Nicholas J, Moss, Stephen J

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Vibrational Circular Dichroism (VCD) Chiral Assignment of Atropisomers: Application to γ-Aminobutyric Acid (GABA) Modulators Designed as Potential Anxiolytic Drugs von Pivonka, Don E., Wesolowski, Steven S.

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Electron Affinity of the Guanine−Cytosine Base Pair and Structural Perturbations upon Anion Formation von Richardson, Nancy A, Wesolowski, Steven S, Schaefer, Henry F

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Structures and Rotational Barriers of a Diiodobinorsnoutane: Energetic Preference for Gauche Conformation von Herres, Joseph P., Moran, Caitlin A., Forman, Mark A., Hall, James E., McCauley, John P., Pivonka, Don E., Wesolowski, Steven S.

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Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human NaV1.7/NaV1.6 Selectivity Ratios von Lopez, Ludivine, Montnach, Jérôme, Oliveira-Mendes, Barbara, Khakh, Kuldip, Thomas, Baptiste, Lin, Sophia, Caumes, Cécile, Wesolowski, Steven, Nicolas, Sébastien, Servent, Denis, Cohen, Charles, Béroud, Rémy, Benoit, Evelyne, De Waard, Michel

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The Adenine−Thymine Base Pair Radical Anion:  Adding an Electron Results in a Major Structural Change von Richardson, Nancy A, Wesolowski, Steven S, Schaefer, Henry F

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Discovery and Preclinical Validation of [11C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor von Schou, Magnus, Varnäs, Katarina, Jureus, Anders, Ahlgren, Charlotte, Malmquist, Jonas, Häggkvist, Jenny, Tari, Lenke, Wesolowski, Steven S, Throner, Scott R, Brown, Dean G, Nilsson, Maria, Johnström, Peter, Finnema, Sjoerd J, Nakao, Ryuji, Amini, Nahid, Takano, Akihiro, Farde, Lars

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Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D₂ partial agonists von Urbanek, Rebecca A, Xiong, Hui, Wu, Ye, Blackwell, William, Steelman, Gary, Rosamond, Jim, Wesolowski, Steven S, Campbell, James B, Zhang, Minli, Brockel, Becky, Widzowski, Daniel V

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Developing dual functional allosteric modulators of GABA(A) receptors von Liu, Xiaodong F, Chang, Hui-Fang, Schmiesing, Richard Jon, Wesolowski, Steven S, Knappenberger, Katharine S, Arriza, Jeffrey L, Chapdelaine, Marc J

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Developing dual functional allosteric modulators of GABAA receptors von Liu, Xiaodong F., Chang, Hui-Fang, Schmiesing, Richard Jon, Wesolowski, Steven S., Knappenberger, Katharine S., Arriza, Jeffrey L., Chapdelaine, Marc J.

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4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates von Dantzman, Cathy L., King, Megan M., Ernst, Glen E., Wang, Xia, McCauley, John P., Andisik, Donald W., Brush, Kelly, Bui, Khanh H., Frietze, William, Hoesch, Valerie, Liu, Jay, Palmer, William E., Spear, Nathan, Hudzik, Thomas J., Wesolowski, Steven S.

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