Utility of the 13C‐pantoprazole breath test as a CYP2C19 phenotyping probe for children von Feldman, Keith, Kearns, Gregory L., Pearce, Robin E., Abdel‐Rahman, Susan M., Steven Leeder, James, Friesen, Alec, Staggs, Vincent S., Gaedigk, Andrea, Weigel, Jaylene, Shakhnovich, Valentina

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Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective von Chu, Xiaoyan, Prasad, Bhagwat, Neuhoff, Sibylle, Yoshida, Kenta, Leeder, James Steven, Mukherjee, Dwaipayan, Taskar, Kunal, Varma, Manthena V. S., Zhang, Xinyuan, Yang, Xinning, Galetin, Aleksandra

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The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity von Dinh, Jean C., Boone, Erin C., Staggs, Vincent S., Pearce, Robin E., Wang, Wendy Y., Gaedigk, Roger, Leeder, James Steven, Gaedigk, Andrea

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PharmGKB summary: methotrexate pathway von Mikkelsen, Torben S, Thorn, Caroline F, Yang, Jun J, Ulrich, Cornelia M, French, Deborah, Zaza, Gianluigi, Dunnenberger, Henry M, Marsh, Sharon, McLeod, Howard L, Giacomini, Kathy, Becker, Mara L, Gaedigk, Roger, Leeder, James Steven, Kager, Leo, Relling, Mary V, Evans, William, Klein, Teri E, Altman, Russ B

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Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children von Feldman, Keith, Kearns, Gregory L, Pearce, Robin E, Abdel-Rahman, Susan M, Steven Leeder, James, Friesen, Alec, Staggs, Vincent S, Gaedigk, Andrea, Weigel, Jaylene, Shakhnovich, Valentina

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Determinants of Variability in Divalproex Sodium (VPA) Glucuronidation in Children von Leeder, James Steven, Pearce, Robin E, Price, Kristin E, Ward, Robert M, Bale, James F, Abbott, Frank S, Chang, Thomas KH, Kennedy, Mary Jayne, Sullivan, Janice, Gaedigk, Andrea

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Variability in valproic acid (VPA) metabolite signatures in children von Leeder, James Steven, Gaedigk, Andrea, Pearce, Robin E., Abbott, Frank S., Chang, Thomas K.H., Kiang, Tony, Teng, XiaoWei, Kennedy, Mary Jayne, Ward, Robert M.

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R-TRIHEXYPHENIDYL FOR TREATMENT OF MOVEMENT DISORDERS von LEEDER, James Steven, GELINEAU-MOREL, Rose, TOREN, Paul C

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy von Brown, Jacob T., Bishop, Jeffrey R., Sangkuhl, Katrin, Nurmi, Erika L., Mueller, Daniel J., Dinh, Jean C., Gaedigk, Andrea, Klein, Teri E., Caudle, Kelly E., McCracken, James T., Leon, Jose, Leeder, J. Steven

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants von Bousman, Chad A., Stevenson, James M., Ramsey, Laura B., Sangkuhl, Katrin, Hicks, J. Kevin, Strawn, Jeffrey R., Singh, Ajeet B., Ruaño, Gualberto, Mueller, Daniel J., Tsermpini, Evangelia Eirini, Brown, Jacob T., Bell, Gillian C., Leeder, J. Steven, Gaedigk, Andrea, Scott, Stuart A., Klein, Teri E., Caudle, Kelly E., Bishop, Jeffrey R.

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Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother von Koren, Gideon, Cairns, James, Chitayat, David, Gaedigk, Andrea, Leeder, Steven J

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Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes von Goldman, Jennifer L, Koen, Yakov M, Rogers, Steven A, Li, Kelin, Leeder, James S, Hanzlik, Robert P

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Safety of codeine during breastfeeding Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine von Madadi, Parvaz, Koren, Gideon, Cairns, James, Chitayat, David, Gaedigk, Andrea, Leeder, J Steven, Teitelbaum, Ronni, Karaskov, Tatyana, Aleksa, Katarina

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Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease von Shakhnovich, Valentina, Vyhlidal, Carrie, Friesen, Craig, Hildreth, Amber, Singh, Vivekanand, Daniel, James, Kearns, Gregory L, Leeder, J Steven

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Coordinated care versus standard care in hospital admissions of people with chronic illness: a randomised controlled trial von Plant, Natalie A, Kelly, Patrick J, Leeder, Stephen R, D'Souza, Mario, Mallitt, Kylie‐Ann, Usherwood, Tim, Jan, Stephen, Boyages, Steven C, Essue, Beverley M, McNab, Justin, Gillespie, James A

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Atomoxetine Therapy von Brown, Jacob T., Bishop, Jeffrey R., Sangkuhl, Katrin, Nurmi, Erika L., Mueller, Daniel J., Dinh, Jean C., Gaedigk, Andrea, Klein, Teri E., Caudle, Kelly E., McCracken, James T., de Leon, Jose, Leeder, J. Steven

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Demographic and clinical predictors of unplanned hospital utilisation among chronically ill patients: a prospective cohort study von Mallitt, Kylie-Ann, Kelly, Patrick, Plant, Natalie, Usherwood, Tim, Gillespie, James, Boyages, Steven, Jan, Stephen, Leeder, Stephen

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Why has model-informed precision dosing not yet become common clinical reality?:Lessons from the past and a roadmap for the future von Darwich, Adam, Ogungbenro, Kayode, Vinks, Alexander A, Powell, J. Robert, Reny, Jean-Luc, Marsousi, Niloufar, Daali, Youssef, Fairman, David, Cook, Jack, Lesko, Lawrence J, McCune, Jeannine S, Knibbe, Catherijne A.J, de Wildt, Saskia N, Leeder, J. Steven, Neely, Michael N, Zuppa, Athena F, Vicini, Paolo, Aarons, Leon, Johnson, Trevor N, Boiani, James, Rostami-Hodjegan, Amin

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P-209 YI Decreased Pregnane X Receptor (PXR) Expression in Inflamed Versus Non-Inflamed Small Bowel of Children with Crohn’s Disease von Shakhnovich, Valentina, Vyhlidal, Carrie, Friesen, Craig, Hildreth, Amber, James, Daniel, Singh, Vivekanand, San Pablo, William, Kearns, Gregory, Leeder, Steven

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Implementation and effectiveness of 'care navigation', coordinated management for people with complex chronic illness: rationale and methods of a randomised controlled trial von Plant, Natalie, Mallitt, Kylie-Ann, Kelly, Patrick J, Usherwood, Tim, Gillespie, James, Boyages, Steven, Jan, Stephen, McNab, Justin, Essue, Beverley M, Gradidge, Kathy, Maranan, Nereus, Ralphs, David, Aspin, Clive, Leeder, Stephen

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